Serological Evidence of Pneumonia Virus of Mouse (PVM) Infection in Laboratory Rats

Miyata, Hironori; Watanabe, Yoji; Kondo, H.; Yagami, Ken‐ichi; Sato, Hiroshi

doi:10.1538/expanim1978.42.3_371

Experimental Animals

1993

DOI: 10.1538/expanim1978.42.3_371

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Serological Evidence of Pneumonia Virus of Mouse (PVM) Infection in Laboratory Rats

Hironori Miyata

Yoji Watanabe

H. Kondo

et al.

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Cited by 3 publications

(1 citation statement)

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“…PVM is a paramyxovirus, subfamily pneumovirus, that naturally targets a rodent host (17)(18)(19) and replicates many of the acute inflammatory responses described for RSV in humans (20,21). Easton and colleagues (22)(23)(24)(25) have characterized the genome of this virus, documenting similarities in gene order and among specific primary sequences and demonstrating that PVM is the phylogenetically nearest known relative of RSV.…”

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confidence: 99%

The Chemokine Macrophage-Inflammatory Protein-1α and Its Receptor CCR1 Control Pulmonary Inflammation and Antiviral Host Defense in Paramyxovirus Infection

Domachowske

Bonville

Gao

et al. 2000

The Journal of Immunology

154

136

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In this work, we explore the responses of specific gene-deleted mice to infection with the paramyxovirus pneumonia virus of mice (PVM). We have shown previously that infection of wild type mice with PVM results in pulmonary neutrophilia and eosinophilia accompanied by local production of macrophage-inflammatory protein-1α (MIP-1α). Here we examine the role of MIP-1α in the pathogenesis of this disease using mice deficient in MIP-1α or its receptor, CCR1. The inflammatory response to PVM in MIP-1α-deficient mice was minimal, with ∼10–60 neutrophils/ml and no eosinophils detected in bronchoalveolar lavage fluid. Higher levels of infectious virus were recovered from lung tissue excised from MIP-1α-deficient than from fully competent mice, suggesting that the inflammatory response limits the rate of virus replication in vivo. PVM infection of CCR1-deficient mice was also associated with attenuated inflammation, with enhanced recovery of infectious virus, and with accelerated mortality. These results suggest that the MIP-1α/CCR1-mediated acute inflammatory response protects mice by delaying the lethal sequelae of infection.

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confidence: 99%

The Chemokine Macrophage-Inflammatory Protein-1α and Its Receptor CCR1 Control Pulmonary Inflammation and Antiviral Host Defense in Paramyxovirus Infection

Domachowske

Bonville

Gao

et al. 2000

The Journal of Immunology

154

136

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Pulmonary Eosinophilia and Production of MIP-1α Are Prominent Responses to Infection with Pneumonia Virus of Mice

Domachowske

Bonville

Dyer

et al. 2000

Cellular Immunology

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New Isolates of Pneumonia Virus of Mice (PVM) from Japanese Rat Colonies and their Characterization.

et al. 1995

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Two virus strains were isolated from the lungs of athymic rats and mice used as sentinel animals in 2 colonies of laboratory rats in Japan in which antibodies to the pneumonia virus of mice (PVM) had been detected. The new isolates were identified as PVM by the following characteristics: RNA virus, susceptibility to ether treatment, long filamentous viral structure in the cytoplasm of infected cells, and hemagglutinating activity in various erythrocytes, including those of mice and rats. In addition, cross neutralization with the prototype of PVM (No. 15 strain) was observed. This is the first report of the isolation of PVM from laboratory animals in Japan.

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Serological Evidence of Pneumonia Virus of Mouse (PVM) Infection in Laboratory Rats

Cited by 3 publications

References 14 publications

The Chemokine Macrophage-Inflammatory Protein-1α and Its Receptor CCR1 Control Pulmonary Inflammation and Antiviral Host Defense in Paramyxovirus Infection

The Chemokine Macrophage-Inflammatory Protein-1α and Its Receptor CCR1 Control Pulmonary Inflammation and Antiviral Host Defense in Paramyxovirus Infection

Pulmonary Eosinophilia and Production of MIP-1α Are Prominent Responses to Infection with Pneumonia Virus of Mice

New Isolates of Pneumonia Virus of Mice (PVM) from Japanese Rat Colonies and their Characterization.

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