Serological and Clinical Features of Patients with Myasthenia Gravis in North Indian Population

Autoantibodies to Agrin in Myasthenia Gravis Patients

“…Thus, it seems that MuSK antibody-associated MG may have different etiological and pathological mechanisms from those of the AChR antibody associated MG. This concept is also supported by the observation that MG patients with MuSK antibodies patients do not appear to have thymic hyperplasia or thymoma [62]–[66]. The pathogenic role of LRP4 autoantibodies has been presented in the EAMG recently by our lab [67].…”

Autoantibodies to Agrin in Myasthenia Gravis Patients

“…Thus, it seems that MuSK antibody-associated MG may have different etiological and pathological mechanisms from those of the AChR antibody associated MG. This concept is also supported by the observation that MG patients with MuSK antibodies patients do not appear to have thymic hyperplasia or thymoma [62]–[66]. The pathogenic role of LRP4 autoantibodies has been presented in the EAMG recently by our lab [67].…”

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

“…In addition, patients with anti-MuSK do not appear to have thymic hyperplasia or thymoma. [49][50][51][52][53] Whether and how LRP4 autoantibodies are pathogenic requires further study. We have demonstrated that some serum samples with anti-LRP4 antibodies but without anti-AChR antibodies and anti-MuSK antibodies were able to disrupt the agrin-LRP4 interaction and inhibit agrininduced AChR clustering.…”

Myasthenia Gravis

“…In 7% of patients only presenting feature was weakness of ocular muscles. 8 In the patients who were above 50 years of age dyspnoea was frequent as diplopia (25%). However diagnosis is not straight in all the cases and delayed or missed diagnosis frequently occurs.…”

Autoantibodies to Agrin in Myasthenia Gravis Patients

“…Thus, it seems that MuSK antibody-associated MG may have different etiological and pathological mechanisms from those of the AChR antibody associated MG. This concept is also supported by the observation that MG patients with MuSK antibodies patients do not appear to have thymic hyperplasia or thymoma [62]–[66]. The pathogenic role of LRP4 autoantibodies has been presented in the EAMG recently by our lab [67].…”

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

“…In addition, patients with anti-MuSK do not appear to have thymic hyperplasia or thymoma. [49][50][51][52][53] Whether and how LRP4 autoantibodies are pathogenic requires further study. We have demonstrated that some serum samples with anti-LRP4 antibodies but without anti-AChR antibodies and anti-MuSK antibodies were able to disrupt the agrin-LRP4 interaction and inhibit agrininduced AChR clustering.…”

Myasthenia Gravis

“…In 7% of patients only presenting feature was weakness of ocular muscles. 8 In the patients who were above 50 years of age dyspnoea was frequent as diplopia (25%). However diagnosis is not straight in all the cases and delayed or missed diagnosis frequently occurs.…”

Autoantibodies to Agrin in Myasthenia Gravis Patients

“…Thus, it seems that MuSK antibody-associated MG may have different etiological and pathological mechanisms from those of the AChR antibody associated MG. This concept is also supported by the observation that MG patients with MuSK antibodies patients do not appear to have thymic hyperplasia or thymoma [62]–[66]. The pathogenic role of LRP4 autoantibodies has been presented in the EAMG recently by our lab [67].…”

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

“…In addition, patients with anti-MuSK do not appear to have thymic hyperplasia or thymoma. [49][50][51][52][53] Whether and how LRP4 autoantibodies are pathogenic requires further study. We have demonstrated that some serum samples with anti-LRP4 antibodies but without anti-AChR antibodies and anti-MuSK antibodies were able to disrupt the agrin-LRP4 interaction and inhibit agrininduced AChR clustering.…”

Myasthenia Gravis

“…In 7% of patients only presenting feature was weakness of ocular muscles. 8 In the patients who were above 50 years of age dyspnoea was frequent as diplopia (25%). However diagnosis is not straight in all the cases and delayed or missed diagnosis frequently occurs.…”