Seroepidemiology of Pertussis in Italy

Giammanco, Anna; Chiarini, A; Stroffolini, Tommaso; Mattia, Domenico De; Chiaramonte, M.; Moschen, Maria Elisa; Mura, I; Rigo, G.; Taormina, Susanna; Sarzana, Antonella; Mazza, Giulia; Scarpa, B

doi:10.1093/clinids/13.6.1216

Cited by 41 publications

(26 citation statements)

References 13 publications

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“…Previous studies have shown that antibody levels against PT and FHA antigens are generally parallel (9,11). Furthermore, most serological surveys have not evaluated newborns, infants, or adults for immunity against pertussis (10)(11)(12). The aim of this study was to investigate the seroepidemiology of B. pertussis infections in a healthy northern Greek population, in subjects ranging from 1 day old to 80 years old.…”

Section: Discussionmentioning

confidence: 99%

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Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Polyzou

Pournaras

Dafni

et al. 2004

Clinical Laboratory Analysis

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A seroepidemiological study was conducted on a representative sample of the northern Greek population (healthy individuals, age range=1 day to 80 years) to assess the prevalence of antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA). Antibody concentrations were significantly elevated with age (analysis of variance (ANOVA), P<0.001). In addition, a significant increase in antibody levels was detected in subjects >50 years old compared to children aged 5-10 years (post-hoc Scheffe analysis, P=0.007). These data suggest that pertussis occurs frequently in Greek adults, and that sometimes a fifth booster vaccine dose is not given after the second year of life. Routine revaccination with the acellular vaccine for children >4 years of age, adolescents, and adults should be considered in order to ensure effective protection of the whole population.

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Section: Discussionmentioning

confidence: 99%

“…Serodiagnosis of pertussis has been used as evidence to support the need for immunizations in various populations (9)(10)(11)(12). However, there are no well-defined criteria for evaluating the results of seroepidemiology of pertussis (5,9,12).…”

Section: Discussionmentioning

confidence: 99%

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Polyzou

Pournaras

Dafni

et al. 2004

Clinical Laboratory Analysis

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“…1% of the examined samples. In 1988-1989, during a period of low vaccination coverage, the seroprevalence of IgG anti-PT in unvaccinated 19-yearold subjects was >80% [34], while in 1994-1995 a prevalence of 71 . 6 % was recorded in students aged 17-25 years [21].…”

Section: Discussionmentioning

confidence: 99%

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

et al. 2008

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SUMMARYHumoral and cell-mediated immunity (CMI) against B. pertussis was assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99 . 1 %) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [o2 ELISA units (EU)/ml]. There were no significant differences between the genders ; 6 . 2 % samples recorded titres o100 EU/ml. CMI was positive [stimulation index (SI) o5] against PT in 39 . 0 % of all samples. This study suggests that B. pertussis continues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pertussis boosters may be of value in these populations. Nevertheless, over the last 10 years, large increases in vaccination coverage rates have contributed to reduce the spread of the aetiological agent, especially in the immunized population.

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“…Perbedaan yang tidak bermakna dalam hal GMT menurut jenis kelamin juga didapatkan pada penelitian di Taiwan dan Italia, 12,13 namun penelitian yang dilakukan oleh Inandi dkk 14 di Turki (n=781) mendapatkan geometric mean titers (GMT) yang lebih tinggi pada anak lelaki dibandingkan dengan anak perempuan.…”

Section: Pembahasanunclassified

Seroproteksi Antibodi Anti-pertusis pada anak usia 6 - 7 Tahun dengan Riwayat Vaksinasi DTP Dasar Lengkap dan Ulangan di Sekolah Dasar di Jakarta

Deasiyanti

2016

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Latar belakang. Angka kejadian pertusis semakin meningkat selama dua dekade terakhir walaupun cakupan vaksinasi DTP sudah cukup tinggi. Peningkatan insidens kasus pertusis terutama terlihat pada usia remaja dan dewasa, sehingga menjadi sumber penular yang penting terhadap bayi kecil. Kekebalan yang menurun merupakan salah satu penyebab peningkatan insidens pertusis sehingga kebutuhan booster pertusis pada usia remaja dan dewasa menjadi perhatian para peneliti. Tujuan. Mengetahui proporsi seroproteksi dan rerata kadar antibodi anti-pertusis pada anak usia 6-7 tahun di Jakarta, baik yang mendapatkan vaksinasi dasar DTP (3 kali) maupun yang mendapatkan vaksinasi dasar dan ulangan (lebih dari 3 kali). Metode. Uji potong lintang deskriptif dilakukan di enam sekolah dasar di Jakarta selama Mei-Juli 2010. Subjek adalah anak usia 6-7 tahun (siswa SD kelas 1) yang telah mendapatkan vaksinasi DTP 3 kali atau lebih. Pada setiap subjek dilakukan pemeriksaan kadar antibodi anti-pertusis. Hasil. Subjek 75 orang anak, 38 lelaki dan 37 perempuan diikutsertakan dalam penelitian, rerata usia (6,2+0,41) tahun. Sebagian besar subjek (68%) memiliki status gizi baik dan 1 subjek (1,3%) dengan gizi buruk. Tiga puluh delapan (50,7%) subjek dengan riwayat vaksinasi DTP sebanyak 3 kali, 31 (41,3%) subjek dengan riwayat vaksinasi 4 kali, dan 6 (8%) subjek dengan riwayat vaksinasi 5 kali. Didapatkan proporsi antibodi antipertusis dengan seropositif 56%. Seroproteksi antibodi anti-pertusis pada subjek yang mendapatkan vaksinasi DTP 3 kali adalah 50%, pada subjek dengan riwayat vaksinasi 4 kali 54,8% dan pada subjek dengan riwayat vaksinasi 5 kali 100%. Rentang kadar antibodi anti-pertusis (0-1437,2) EU/mL. Nilai median seroproteksi antibodi anti-pertusis pada subjek dengan riwayat vaksinasi DTP 3 kali adalah 43,6 EU/mL, riwayat vaksinasi 4 kali 104 EU/mL, dan riwayat vaksinasi 5 kali 104,9 EU/mL. Kesimpulan. Kekebalan yang didapat dari vaksinasi tidak dapat bertahan lama, sehingga diperlukan pemberian vaksinasi ulangan (booster), baik pada usia 18-24 bulan dan usia sekolah (SD kelas 1). Selain itu juga perlu dipertimbangkan pemberian booster pada usia remaja. Sari Pediatri 2011;13(1):26-32.Kata kunci: pertusis, vaksinasi DTP, seroproteksi, booster Alamat korespondensi:Dr. Runi Deasiyanti, SpA. Departemen Ilmu Kesehatan Anak FKUI-RSCM. Jl. Salemba no. 6, Jakarta 10430, Telp. 021-3914126.

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Seroepidemiology of Pertussis in Italy

Cited by 41 publications

References 13 publications

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

Seroproteksi Antibodi Anti-pertusis pada anak usia 6 - 7 Tahun dengan Riwayat Vaksinasi DTP Dasar Lengkap dan Ulangan di Sekolah Dasar di Jakarta

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