Sero-prevalence of leptospirosis and differentiation in blood parameters between positive and negative cases in dogs of Kathmandu Valley

Ojha, Krishna Chandra; Singh, Dinesh Kumar; Kaphle, Krishna; Shah, Yogendra; Pant, Dhan Kumar

doi:10.1093/trstmh/try065

Cited by 5 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have reported variable prevalence in dogs ranging from 1.8% in Australia to 71.1% in India (Davis et al., 2008; Zwijnenberg et al., 2008; Shi et al., 2012; Ambily et al., 2013; Bier et al., 2013; Ojha et al., 2018). In Europe, the prevalence ranges from 6% in Ireland to 49% in Italy (Scanziani et al., 2002; Burriel et al., 2003; Schuller et al., 2015b; Llewellyn et al., 2016; Habus et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Leptospira seroprevalence in owned dogs from Spain

López

Vilà

Rodón³

et al. 2019

Heliyon

View full text Add to dashboard Cite

Leptospira is a widespread zoonosis that has been linked to transmission between dogs and humans. The main purposes were to determine the seroprevalence of anti- Leptospira serum antibody and to identify the most common serovars in dogs in Spain. This is a cross-sectional study with 1,310 records of canine Leptospira testing data from Spain since 2015 to 2017. Inclusion criteria were individual cases with MAT test results for 8 serovars (Bratislava, Icterohaemorrhagiae, Australis, Pomona, Grippotyphosa, Autumnalis, Canicola and Saxkoebing) and to have the zip code data. Three hundred and thirty-eight samples (25.8%; 95%CI 23.6–28.4) were seropositive (≥1:100). According to geographic areas, North had the highest seroprevalence (38.0%; 95%CI 28.9–47.1) followed by South (29.4%; 95%CI 20.1–38.8), Center (28.6%; 95%CI 24.3–33.0), Mediterranean (22.3%; 95%CI 19.1–25.6) and Northwest (22.2%; 95%CI 7.9–36.4). Seropositivity (MAT ≥1:100) was most common to serovars Icterohaemorrhagiae (19.4%; 95%CI 17.2–21.5) and Bratislava (8.5%; 95%CI 7.0–10.0), followed by Grippotyphosa (7.2%; 95%CI 5.8–8.6), Australis (6.4%; 95%CI 5.0–7.7), Autumnalis (5.0%; 95%CI 3.8–6.2), Pomona (4.5%; 95%CI 3.3–5.6), Canicola (3.4%; 95%CI 2.4–4.4) and Saxkoebing (0.8%; 95%CI 0.3–1.3). An association was found between positivity (MAT ≥1:100) and males (P = 0.003) and dogs that were 6 years old or older were at higher risk of exposure (P = 0.001; OR 4.61; 95%CI 1.86–11.43). This study has shown that dogs in Spain are commonly exposed to Leptospira infection and points out the necessity to control the prevalence of this severe widespread zoonosis in dogs and humans.

show abstract

Section: Introductionmentioning

confidence: 99%

Leptospira seroprevalence in owned dogs from Spain

López

Vilà

Rodón³

et al. 2019

Heliyon

View full text Add to dashboard Cite

show abstract

“…Among the 70 dog's blood sample collected from Kathmandu at 2016, on serological analysis 9 sample i.e. 11.4% was positive for Leptospira (KC et al, 2018). In serological analysis of 200 infertile animals ( 114cows and 86 buffaloes), 8.5% animals (11% cows and 5.5% buffaloes) were positive for Leptospirahardo (Joshi, 2000).…”

Section: Leptospirosismentioning

confidence: 99%

Prioritised Zoonotic Diseases of Nepal: A Review

Gautam

Upadhayay

Ghimre

et al. 2021

Int J Appl Sci Biotechnol

Self Cite

View full text Add to dashboard Cite

World Organization for Animal Health (OIE) has estimated that 60% of infectious diseases and 75% of emerging and re-emerging diseases of humans have an animal origin. In Nepal there six zoonoses; Taeniasis/cysticercosis /Neurocysticercosis, Leptospirosis, Hydatidosis, Brucellosis; Toxoplasmosis and Avian Influenza are identified as priorities zoonotic diseases as they are found to have epidemic potential. Although they are prioritised, there is high prevalence of these diseases in both humans and animals with insufficient research and data. Coordination of multiple stakeholders of public and animal health and One Health collaboration are crucial to control and elimination zoonotic diseases in Nepal. Int. J. Appl. Sci. Biotechnol. Vol 9(1): 1-15

show abstract

“…Важливим для вивчення особливо небезпечних зоонозів лишається клініко-діагностична інформативність, адже закордонні дослідники виявляли антитіла до лептоспірозу у невакцинованих собак, це створює значну загрозу для людства (Ojha et al, 2018), тому наукові пошуки щодо більш глибокого розуміння патогенезу лептоспірозу у собак є актуальним і необхідним. У зв'язку з цим метою наших досліджень було встановити можливість оцінки ендогенної інтоксикації у собак за лептоспірозу на основі показників лейкоцитарних індексів їх крові.…”

Section: вступunclassified

“…Підвищення кількості паличкоядерних на фоні зниження сегментоядерних нейтрофілів (зсув лейкоцитарної формули вліво) характеризує запальний процес з розвитком інтоксикації організму. Сегментоядерні нейтрофіли виконують важливу роль у процесі придушення активності бактерій за рахунок вмісту спеціальних білків, що володіють властивостями антибіотиків, тому зниження їх кількості викликає занепокоєння та передбачає корекцію етіотропної терапії (Ojha et al, 2018;Kim et al, 2019;Radzykhovsʹkyy et al, 2019). Достовірне підвищення кількості еозинофілів (P  0,05) притаманно для розвитку алергічного стану.…”

Section: таблицяunclassified

Integrated indices as a criterion for evaluation of the level of endogenous intoxication for leptospirosis in dogs

Radzikhovskyi¹,

Недосеков

Dyshkant

et al. 2021

SMLNUVMB

View full text Add to dashboard Cite

One of the most important directions in the development of modern veterinary medicine is the improvement and implementation of modern methods of diagnosis and prognosis of diseases based on determining the degree of dysfunction and the possibility of correcting the protective functions of the body. for most veterinary clinics, the study of the immunological status of animals is not available, and clinical blood tests make it possible to determine the assessment of the functional state of the immune system by integrated hematological parameters. In the article on the basis of blood formulas that reflect the state of neurohumoral homeostasis and immunological reactivity of the organism, for the first time investigated and established violations of humoral and cellular immune systems, micro- and macrophage systems, reduced nonspecific protection and found relationships between immunity in 23 dogs with leptospirosis, which calculated 19 markers of inflammatory activity, endogenous intoxication, adaptation, nonspecific and immune reactivity. The study was conducted in veterinary clinics in zhytomyr and kyiv, blood for the study was taken from the superficial vein of the forearm v. anterbrachium, medial subcutaneous vein or subcutaneous tibial vein v. saphena. Diagnostic studies to confirm leptospirosis were performed using rapid tests Combo Test IgG Ab/IgM Ab, vetlaboratories and elisa on the basis of a private veterinary laboratory of Llc “Bald” in Kiev. The interpretation of integrated leukocyte blood parameters revealed the development of autoimmune processes with suppression of cellular immunity and the development of endogenous intoxication, which indicates an increase in total (P < 0.01), leukocyte (P < 0.05) and nuclear index (P< 0.001). Suppression of the immune response and increased hypersensitivity of the immediate type based on a decrease in non-specific reactivity by P < 0.001 and inflammation index by P < 0.05. It is proved that integrated hematological parameters of peripheral blood increase the informativeness of the general analysis of blood in dogs with infectious diseases and allow to determine not only the degree of reactivity of the organism, but also to assess the level of endogenous intoxication.

show abstract

Sero-prevalence of leptospirosis and differentiation in blood parameters between positive and negative cases in dogs of Kathmandu Valley

Abstract: Detection of Leptospira antibody in non-vaccinated dogs indicates a significant threat to human population and demand unique strategic action plan for the control and prevention of disease.

Cited by 5 publications

References 14 publications

Leptospira seroprevalence in owned dogs from Spain

Leptospira seroprevalence in owned dogs from Spain

Prioritised Zoonotic Diseases of Nepal: A Review

Integrated indices as a criterion for evaluation of the level of endogenous intoxication for leptospirosis in dogs

Contact Info

Product

Resources

About