Sero-Prevalence of Herpesvirus Papio 2 in Wild-Caught Olive Baboons from Selected Regions in Kenya

Chepkwony, Sharon

doi:10.16966/2473-1846.118

Cited by 3 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is relatively lower than the global prevalence of Herpesvirus papio 2, which ranges from 70 to 80% [20] . This study finding is lower than that of another study by Chepkwony et al (2016) [16] , reporting a sero-prevalence of 87%, a relatively higher prevalence because the use of antigens assumes shedding of viruses. According to their study results [16] , only 42% of the baboons were positive in PCR test.…”

Section: Discussioncontrasting

confidence: 80%

“…So far, several of these viruses, closely related to human viruses, have been isolated from NHP species [1] . Some of these NHP neuro-tropic viruses that are similar to human simplex virus (HSV) include: Herpesvirus papio 2 (HVP2) (also called Cercopithecine herpesvirus 16) in baboons, Herpesvirus saimiri 1 (commonly called Saimirine herpesvirus 1) in squirrel monkeys, monkey B virus (BV) (also called Cercopithecine herpesvirus 1) in macaque species of monkeys, and simian agent 8 (SA8) (or Cercopithecine herpesvirus 2) that infect African green monkeys [2] . All these viruses are characterized by a short life cycle and a linear DNA genome of about 155 kbp.…”

Section: Introductionmentioning

confidence: 99%

“…About 68% of the adult population in Kenya is affected by this disease [15] . Genetically and phylogenetically, Papio species are closely related to humans more than all other NHPs, and HVP2 and HSV viruses in their corresponding native hosts are similar [16] . This makes baboons the best animal models for understanding the etiology of HSV in humans.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Kemunto

Kevin²,

Joseph³

et al. 2022

IEM

View full text Add to dashboard Cite

Backgrounds: There is a remarkable similarity between Herpesvirus papio 2 (HVP2) infecting baboons and human simplex virus (HSV) in terms of molecular biology, protein functions, and resulting infections. However, no definitive therapy exists, and the available drugs only improve the clinical signs of recurrent or asymptomatic infections. This research results may be useful for studies on the quest for HVP2 curative and preventive drugs in baboon models. Later, a similar study could be done on HSV in humans. Materials & Methods: A total of 60 baboons were sampled from six different counties in Kenya. Of these, 51 cases were wild caught from five counties, and nine cases were from the Institute of Primate Research (IPR) colonies designated as captive baboons. Oral and genital swabs were collected for analysis. The trigeminal ganglia of three study subjects were also aseptically sampled. Polymerase chain reaction test was used to determine the prevalence of HVP2. HVP2-positive samples were sequenced and aligned to GenBank sequences using BLAST to identify specific circulating strains and generate phylogenetic relationships. DnaSP6 was used for genetic diversity analysis. Findings: Among 60 baboons studied, 65% were positive for the virus. One strain, A951, was identified as the prevalent strain. Extremely low fixation index values (Fst) were recorded, showing low genetic diversity within and between subpopulations. Conclusion:The identified strain was non-pathogenic but could be clinically manifested as painful sores on the host's mucosal membranes and cause stillbirths. The virus prevalence was 75.86% in genital samples and 54.86% in oral samples, indicating that oral transmission is less common than genital transmission.

show abstract

Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Kemunto

Kevin²,

Joseph³

et al. 2022

IEM

View full text Add to dashboard Cite

show abstract

“…Molecular assays are popular because of the uniqueness of every microorganism genome which contributes to the high sensitivity and speci city of the approach (Granberg et al, 2015b). NHPs surveillance studies on haemoparasites and viruses have used conventional polymerase chain reaction (PCR) as a diagnostic tool (Ambala, 2014;Chepkwony et al, 2016;Eberhard et al, 2001;Mahieux et al, 1998). Nested PCR, a technique that involves a second PCR assay which targets a more speci c inner region of target sequence has been employed by (Maamun et al, 2011) in detecting Babesia microti-like parasites by targeting Babesia β-tubulin gene.…”

Section: Diagnostic Techniques Employed For Kenyan Nhp Surveillancementioning

confidence: 99%

Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

Akinyi

Stanislaus

Mbuthia

et al. 2021

Preprint

View full text Add to dashboard Cite

Emerging infectious diseases (EIDs) originating from wildlife present a significant threat to global health, security, and economic growth, thus combatting their emergence is a public health priority. Humans and non-human primates (NHPs) exhibit a high degree of overlap in their genetic and physiological similarities, hence making them susceptible to majority of pathogens that can cross the primate species boundaries. However, efforts to understand the potential infectious disease-causing pathogens harbored by wild primate populations has lagged and is yet to be fully explored. Disease surveillance in wildlife to identify probable infectious disease outbreaks has remained a challenge especially in developing countries due to logistical and financial constrains associated with both periodic and longitudinal sample collection. Such loopholes have hampered the preparedness to handle the emerging infectious diseases whenever they arise. In this review we focus on successes, challenges, and proposed solutions for EID surveillance in non-human primate populations in Kenya. We discuss,1) mechanisms of cross species transmission of EIDs, 2) the role of NHPS in EID transmission, 3) results from past NHP pathogen surveillance projects in Kenya and 4) challenges and proposed solutions for NHP-EID surveillance. Finally, we propose that more studies need to include investigations into understanding how cross species transmission occurs in diverse NHP populations and how this impacts one health.

show abstract

“…Baboons carry a herpesvirus designated Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) [ 148 – 150 , 178 , 179 ]. HVP2 is very closely related to SA8 and was originally considered to be the same virus.…”

Section: Zoonotic Infections By Other Nhp Herpesvirusesmentioning

confidence: 99%

Understanding Primate Herpesviruses

Eberle

Jones‐Engel

2017

J Emerg Dis Virol

View full text Add to dashboard Cite

Viruses related to the herpes simplex viruses of humans are present in all nonhuman primate (NHP) species tested and cross species transmission has been documented. The herpesvirus present in macaques, Herpes B virus (BV) rarely causes disease in its natural macaque host. However, when transmitted to a nonnative host, BV has occasionally caused severe and even fatal disease if not treated immediately. Here we present a comprehensive review of the taxonomy, molecular biology, physiology, epidemiology, diagnosis and treatment of BV. We also summarizes what is known about related herpesviruses of other NHP species and the zoonotic potential of these viruses.

show abstract

Sero-Prevalence of Herpesvirus Papio 2 in Wild-Caught Olive Baboons from Selected Regions in Kenya

Cited by 3 publications

References 0 publications

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

Understanding Primate Herpesviruses

Contact Info

Product

Resources

About

Sero-Prevalence of Herpesvirus Papio 2 in Wild-Caught Olive Baboons from Selected Regions in Kenya

Cited by 3 publications

References 0 publications

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

﻿Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

Understanding Primate Herpesviruses

Contact Info

Product

Resources

About

Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges