Serine metabolism in the culture form of Trypanosoma cruzi: Distribution of 14C from serine into metabolic fractions

Clethra fimbriata hexanic extract triggers alteration in the energy metabolism in epimastigotes of Trypanosoma cruzi

“…The pathway that allows the formation of UDP-galactose is linked to the generation of glucose 6-phosphate and this last metabolite could be incorporated into the glycolytic pathway to generate ATP and feed other metabolic pathways such as pentose phosphate ( Roper and Ferguson, 2003 ). Other biosynthetic pathways that participate as carbon and energy sources through the generation of intermediates for the TAC, such as the amino acids proline ( Silber et al, 2002 ; Silber et al, 2005 ; Martins et al, 2009 ; Paes et al, 2013 ), valine, isoleucine, and serine ( Hamptont, 1971 ; Sylvester and Krassner, 1976 ; Cazzulo, 1994 ; Silber et al, 2005 ; Manchola et al, 2016 ), were also found downward trends.…”

Clethra fimbriata hexanic extract triggers alteration in the energy metabolism in epimastigotes of Trypanosoma cruzi

“…The pathway that allows the formation of UDP-galactose is linked to the generation of glucose 6-phosphate and this last metabolite could be incorporated into the glycolytic pathway to generate ATP and feed other metabolic pathways such as pentose phosphate ( Roper and Ferguson, 2003 ). Other biosynthetic pathways that participate as carbon and energy sources through the generation of intermediates for the TAC, such as the amino acids proline ( Silber et al, 2002 ; Silber et al, 2005 ; Martins et al, 2009 ; Paes et al, 2013 ), valine, isoleucine, and serine ( Hamptont, 1971 ; Sylvester and Krassner, 1976 ; Cazzulo, 1994 ; Silber et al, 2005 ; Manchola et al, 2016 ), were also found downward trends.…”

Carbohydrate Effects on Amino Acid Transport by Trypanosoma equiperdum*

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).Little information is available on transport interactions between amino acids and sugars in parasitic flagellates. Glucoseaffected amino acid release was reported for Leishmania rnexicana and Leishmania donouani (9) and the effects of amino acids on carbohydrate uptake were described for T. Zewisi (41).…”

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).…”

The role of l -serine and l -threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi

“…Despite this, in-depth studies of the metabolism of these amino acids in this parasite are scarce. It has been determined that l -Ser triggers the production of CO 2 , indicating its possible use in bioenergetics ( 17 ). In the related organism Trypanosoma brucei, the participation of l -Thr in the mitochondrial metabolism was well demonstrated ( 18 – 20 ).…”

Clethra fimbriata hexanic extract triggers alteration in the energy metabolism in epimastigotes of Trypanosoma cruzi

“…The pathway that allows the formation of UDP-galactose is linked to the generation of glucose 6-phosphate and this last metabolite could be incorporated into the glycolytic pathway to generate ATP and feed other metabolic pathways such as pentose phosphate ( Roper and Ferguson, 2003 ). Other biosynthetic pathways that participate as carbon and energy sources through the generation of intermediates for the TAC, such as the amino acids proline ( Silber et al, 2002 ; Silber et al, 2005 ; Martins et al, 2009 ; Paes et al, 2013 ), valine, isoleucine, and serine ( Hamptont, 1971 ; Sylvester and Krassner, 1976 ; Cazzulo, 1994 ; Silber et al, 2005 ; Manchola et al, 2016 ), were also found downward trends.…”

Carbohydrate Effects on Amino Acid Transport by Trypanosoma equiperdum*

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).Little information is available on transport interactions between amino acids and sugars in parasitic flagellates. Glucoseaffected amino acid release was reported for Leishmania rnexicana and Leishmania donouani (9) and the effects of amino acids on carbohydrate uptake were described for T. Zewisi (41).…”

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).…”

The role of l -serine and l -threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi

“…Despite this, in-depth studies of the metabolism of these amino acids in this parasite are scarce. It has been determined that l -Ser triggers the production of CO 2 , indicating its possible use in bioenergetics ( 17 ). In the related organism Trypanosoma brucei, the participation of l -Thr in the mitochondrial metabolism was well demonstrated ( 18 – 20 ).…”

Clethra fimbriata hexanic extract triggers alteration in the energy metabolism in epimastigotes of Trypanosoma cruzi

“…The pathway that allows the formation of UDP-galactose is linked to the generation of glucose 6-phosphate and this last metabolite could be incorporated into the glycolytic pathway to generate ATP and feed other metabolic pathways such as pentose phosphate ( Roper and Ferguson, 2003 ). Other biosynthetic pathways that participate as carbon and energy sources through the generation of intermediates for the TAC, such as the amino acids proline ( Silber et al, 2002 ; Silber et al, 2005 ; Martins et al, 2009 ; Paes et al, 2013 ), valine, isoleucine, and serine ( Hamptont, 1971 ; Sylvester and Krassner, 1976 ; Cazzulo, 1994 ; Silber et al, 2005 ; Manchola et al, 2016 ), were also found downward trends.…”

Carbohydrate Effects on Amino Acid Transport by Trypanosoma equiperdum*

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).Little information is available on transport interactions between amino acids and sugars in parasitic flagellates. Glucoseaffected amino acid release was reported for Leishmania rnexicana and Leishmania donouani (9) and the effects of amino acids on carbohydrate uptake were described for T. Zewisi (41).…”

“…Amino acid absorption was studied in cultured T . cruri (11)(12)(13)(14)(15) as well as in bloodstream forms of T. lewisi (24), T. equiperdum (40), and T. gambiense (55).…”

The role of l -serine and l -threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi

“…Despite this, in-depth studies of the metabolism of these amino acids in this parasite are scarce. It has been determined that l -Ser triggers the production of CO 2 , indicating its possible use in bioenergetics ( 17 ). In the related organism Trypanosoma brucei, the participation of l -Thr in the mitochondrial metabolism was well demonstrated ( 18 – 20 ).…”