Serial Examination of Serum IL‐8, IL‐10 and IL‐1Ra Levels is Significant in Neonatal Seizures Induced by Hypoxic–Ischaemic Encephalopathy¹

Abstract

We investigated changes in the levels of significant cytokines in relation to neonatal seizures, a pattern of cytokine concentrations serially and the severity of brain insult. The hypoxic–ischaemic encephalopathy‐induced seizure group consisted of 13 patients, and another 15 normal newborns were enrolled as a control group. All of the initial samples were obtained within the first 24 h of admission, and the second samples were obtained between 48 and 72 h in both groups. Only the third samples were taken in the seizure group on the 5th day. During neonatal seizures, the levels of most cytokines increased within 24 h, and, in particular, the levels of interleukin (IL)‐8 significantly increased (P < 0.05). After 48–72 h of seizure onset, the levels of most cytokines decreased, especially, IL‐1Ra; however, IL‐8 and IL‐10 remained increased (P < 0.05). During the prognosis, one patient who was diagnosed with quadriplegic cerebral palsy at 6 months of age presented extreme elevation of IL‐1beta, IL‐1Ra, IL‐6, IL‐8, IL‐10 and tumor necrosis factor‐alpha in the initial sample, reflecting the severity of brain damage. A significant increase in IL‐8 may serve as a biomarker for earlier detection of brain damage in neonatal seizure, if detected within 24 and 48–72 h of the seizure.

Research progress of relationship between hyptoxic ischemic encephalopathy and interleukin in neonates

“…Moreover, the obvious elevation of IL-8 can be used as a biological marker for the prognosis of early HIE brain injury, which is easy to occur in neonatal convulsion. [30] Quiniou et al [31] confirmed the leading role of IL-1 in hypoxicischemic brain damage as an important proinflammatory cytokine. It is involved in the whole process of the occurrence and development of hypoxic-ischemic brain damage.…”

Immunological Parametrs of Umbilical Cord Blood From Children Born to Women With Urogenital Infections

“…Ряд отечественных и зарубежных авторов указывают на существенную роль про-воспалительных цитокинов в развитии перина-тального поражения ЦНС [10,11,15], а также предикторную значимость определения уровня IL-8 для ранней диагностики повреждений го-ловного мозга у новорожденных в течение 72 ча-сов после рождения [14].…”

Blood biomarkers for evaluation of perinatal encephalopathy: state of the art

“…IL-8 increases in the acute phase of injury in neonates with HIE, and the more severe the injury the higher the IL-8 levels (Lv et al, 2015). In a study of 13 neonates with HIE and epilepsy, most inflammatory factors in the serum were decreased after 8-72 h, however, serum IL-8 levels remained high indicating that IL-8 might be an early biomarker for the diagnosis of neonatal HIE with epilepsy (Youn et al, 2012).…”