2007
DOI: 10.7326/0003-4819-146-8-200704170-00006
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Abstract: Sequential therapy is statistically significant compared with standard therapy for eradicating H. pylori infection and is statistically significantly more effective in patients with clarithromycin-resistant strains. Side effects are similar with both treatment regimens and are rarely severe enough to cause discontinuation of therapy. ClinicalTrials.gov registration number: NCT00403364.

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Cited by 289 publications
(255 citation statements)
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“…Studies to examine these hypotheses are needed. Sequential therapy is also not a good choice in the presence of combined clarithromycin and metronidazole resistance and therefore is not an acceptable choice for treatment after multiple failed therapies 58 .…”
Section: Treatment Recommendations For Initial Treatmentmentioning
confidence: 99%
“…Studies to examine these hypotheses are needed. Sequential therapy is also not a good choice in the presence of combined clarithromycin and metronidazole resistance and therefore is not an acceptable choice for treatment after multiple failed therapies 58 .…”
Section: Treatment Recommendations For Initial Treatmentmentioning
confidence: 99%
“…The sequential scheme, developed by Italian researchers, consists of administering a standard dose of proton pump inhibitor with 1.0 g of amoxicillin, twice daily for the 1st 5 days, followed by administering of the standard dose of proton pump inhibitor, 500 mg of clarithromycin and 500 mg of tinidazole administered twice daily for a further 5-day period. Although most studies are still restricted to a single country, the initial results show eradication rates around 90% (58,104,199,216) , with some Asian studies showing less significant results (23) . There is a lack of confirmatory studies as to the effectiveness of this scheme among us.…”
Section: Statement 29mentioning
confidence: 99%
“…1.2. Sequential treatment [9,11]: PPI (pantoprazole 40 mg) + amoxicillin 1000 mg each administered twice daily for 5 days followed by PPI + clarithromycin 500mg + tinidazole 500 mg, each administered twice daily for the remaining 5 days. 2.…”
Section: First-line Regimensmentioning
confidence: 99%
“…26 No 2: 129-137 rapidly increasing worldwide [6] and this trend undermines the efficacy of the standard first-line triple (proton pump inhibitor -PPI, amoxicillin, clarithromycin) therapy, yielding a low eradication rate (<80%) [7][8][9]. Other first-line regimens included the "sequential" (PPI, amoxicillin followed by clarithromicin and tinidazole) therapy [9][10][11]. Alternative second-line (i.e.…”
Section: Introductionmentioning
confidence: 99%