Sequential Hemodynamic Studies in Patients Having Aortic Valve Replacement with the Ionescu-Shiley Pericardial Xenograft

Tandon, Anand P.; Smith, Donald R.; Mary, David A.S.G.; Ionescu, Marian I.

doi:10.1016/s0003-4975(10)63724-1

Cited by 26 publications

(2 citation statements)

References 14 publications

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“…Similar findings have been exercise). A similar correlation was found between reported by Olin (1970), Bjork et al (1971, 1974, mean ejection systolic gradient and the xenograft Bristow and Kremkau (1975), Ionescu et al (1974), size (r=0 991). and Dubiel and Cullhed (1975).…”

Section: Vascular Resistance Aortographysupporting

confidence: 88%

“…that the postoperative circulatory improvement In the present investigation the systolic gradient was maintained and the transvalvular gradient did was inversely related to the annulus diameter of not change with the passage of time (Tandon et al, the xenograft inserted. As expected, augmentation 1977 Reis, 1976;Morris et al, 1976) have has substantiated the results of the clinical assesscommented on the high systolic gradients associated ment. The transvalvular gradients are insignificant with the smaller sizes of Hancock porcine xeno-and predictable.…”

Section: Vascular Resistance Aortographymentioning

confidence: 59%

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Long-term haemodynamic evaluation of aortic pericardial xenograft.

Tandon¹,

Smith²,

Whitaker³

et al. 1978

Heart

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SUMMARY Haemodynamic studies were performed in 30 patients at a mean interval of 43-4 (range 27 to 59) months after aortic valve replacements-withpericardial xenografts. Five valve sizes-19, 21, 23, 25, and 27 mm annulus diameter-were used. Of these 30 patients, 16 had preoperative haemodynamic investigations. Comparison of the pre-and postoperative data showed a marginal but significant increase in cardiac output (P < 0.05). There was a significant reduction in the pulmonary wedge and left ventricular end-diastolic pressures at rest and on exercise (P < 0-05 and P < 0-01).At the postoperative study the mean peak systolic gradient was 8-3 mmHg at rest and 12-3 mmHg on exercise in patients with the smallest xenograft inserted (19 mm) and decreased with each corresponding increase in graft size, so that across the 27 mm graft it was hardly measurable. The calculated xenograft surface area ranged from 1 1 to 2 1 cm2 at rest and 1-3 to 2-4cm2 during exercise. Aortic root angiography showed competent valves in all 30 patients, but a grade 1 to 2 perivalvular leak was shown in 8 patients.This long-term study has indicated significant circulatory improvement and very small transvalvular gradients in patients with aortic pericardial xenografts.

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Section: Vascular Resistance Aortographysupporting

confidence: 88%

Section: Vascular Resistance Aortographymentioning

confidence: 59%