Sequential grade evaluation method exploration of Exocarpium Citri Grandis (Huajuhong) decoction pieces based on “network prediction → grading quantization → efficacy validation"

Liu, Guoxiu; Li, Siyu; Zhang, Nan; Wei, Namin; Wang, Mengxin; Liu, Jiao; Xu, Youzhi; Li, Yanan; Sun, Qianqian; Li, Feng; Yu, Pinhao; Liu, Mengyu; Wang, Yanping; Zhai, Huaqiang; Wang, Yongyan

doi:10.1016/j.jep.2022.115149

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…CGE and flavonoids had anti-inflammatory effects in xylene-induced mice models (37) and LPS-induced RAW264.7 and regulated the activation of MAPK and NF-κB signaling pathways (38). Aqueous extract of CGE also alleviated bleomycin-induced idiopathic pulmonary fibrosis in rat model, which related to the reduction of IL-6, IL-8, TGF-β1, and so on (4). In this study, we re-proved the anti-inflammatory effect in LPS-induced RAW264.7 and reveal the mechanism of CEG through active compounds and potential targets of MAPK14 and MMP9.…”

Section: Discussionmentioning

confidence: 93%

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Discovery of pharmacological effects and targets of Citri Grandis Exocarpium based on SYSTCM and virtual screening

Feng,

Shu,

Fang

et al. 2024

Food & Nutrition Research

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Section: Discussionmentioning

confidence: 93%

“…Naringin is the index component of CGE for quality control in the Chinese Pharmacopoeia (Edition 2020). The content of naringin can reflect the quality of different grades of CGE decoction pieces (4). CGE has a wide range of pharmacological effects, including hypolipidemic, antimicrobial, anti-inflammatory, anticancer, and so on (5).…”

mentioning

confidence: 99%

Discovery of pharmacological effects and targets of Citri Grandis Exocarpium based on SYSTCM and virtual screening

Feng,

Shu,

Fang

et al. 2024

Food & Nutrition Research

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“…It has been used to treat respiratory diseases for hundreds of years ( Su et al., 2020 ). Recent studies have shown that ECG possess antioxidant, anticancer, antibacterial, and anti-inflammatory activities owing to its rich bioactive compound profile ( Fan et al., 2019 ; Peng et al., 2019 ; Liu et al, 2022 ). Duan et al (2014) examined the bioactive compound profile of different tissues of C. grandis and identified the presence of naringin and rhoifolin in the fruit and flower.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic and targeted metabolome analyses revealed the regulatory mechanisms of the synthesis of bioactive compounds in Citrus grandis ‘tomentosa’

Huang,

Liu,

Wang

et al. 2024

PeerJ

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Exocarpium Citri Grandis is a popular Chinese herbal medicine prepared from Citrus grandis ‘tomentosa’, and it is rich in several bioactive compounds, including flavonoids, coumarins, and volatile oils. However, studies are yet to elucidate the mechanisms of synthesis and regulation of these active components. Therefore, the present study examined the profiles of flavonoids and volatile oil bioactive compounds in plant petals, fruits, and tender leaves, and then performed RNA sequencing on different tissues to identify putative genes involved in the synthesis of bioactive compounds. The results show that the naringin, naringenin, and coumarin contents of the fruitlets were significantly higher than those of the tender leaves and petals, whereas the tender leaves had significantly higher levels of rhoifolin and apigenin. A total of 49 volatile oils, of which 10 were mainly found in flowers, 15 were mainly found in fruits, and 18 were mainly found in leaves, were identified. RNA sequencing identified 9,942 genes that were differentially expressed in different tissues. Further analysis showed that 20, 15, and 74 differentially expressed genes were involved in regulating flavonoid synthesis, regulating coumarin synthesis, and synthesis and regulation of terpenoids, respectively. CHI1 (Cg7g005600) and 1,2Rhat gene (Cg1g023820) may be involved in the regulation of naringin synthesis in C. grandis fruits. The HDR (Cg8g006150) gene, HMGS gene (Cg5g009630) and GGPS (Cg1g003650) may be involved in the regulation and synthesis of volatile oils in C. grandis petals. Overall, the findings of the present study enhance our understanding of the regulatory mechanisms of secondary metabolites in C. grandis, which could promote the breeding of C. grandis with desired characteristics.

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“…Citri Grandis Exocarpium (Huajuhong in Chinese) belongs to the Rutaceae family, and it is the unmature or nearly mature dry exocarp of Citrus grandis “ Tomentosa ” and C. grandis (L.) Osbeck 321 . The main components of Citri Grandis Exocarpium are flavonoids, including naringin, rhoifolin, and apigenin 322 . Citri Grandis Exocarpium increased the mRNA expression of PXR and peroxisome proliferator activated receptor α (PPAR α ) and the activities of CYP1A1, 1A2, 2B, and 2E1 323 .…”

Section: Tcms For the Treatment Of Covid-19 Infectionsmentioning

confidence: 99%

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

Ye¹,

Fan²,

Zhao³

et al. 2023

Acta Pharmaceutica Sinica B

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Sequential grade evaluation method exploration of Exocarpium Citri Grandis (Huajuhong) decoction pieces based on “network prediction → grading quantization → efficacy validation"

Cited by 6 publications

References 32 publications

Discovery of pharmacological effects and targets of Citri Grandis Exocarpium based on SYSTCM and virtual screening

Discovery of pharmacological effects and targets of Citri Grandis Exocarpium based on SYSTCM and virtual screening

Transcriptomic and targeted metabolome analyses revealed the regulatory mechanisms of the synthesis of bioactive compounds in Citrus grandis ‘tomentosa’

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

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