Sequential Bilateral Corneal Transplantation and Graft Survival

Steger, Bernhard; Curnow, Elinor; Cheeseman, Robert; Romano, Vito; Kaye, Abigail; Jones, Mark; Kaye, Stephen B.

doi:10.1016/j.ajo.2016.07.019

Cited by 18 publications

(18 citation statements)

References 32 publications

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“…Patients were excluded if they received a graft in the fellow eye because it is known that such grafts can have a different survival profile. 20 After submission of the proposed analysis by the NHSBT, the research was approved by the Audit and Clinical Research subgroup of the Ocular Tissue Advisory Group. Patients gave general consent for use of their data for research and governance purposes.…”

Section: Methodsmentioning

confidence: 99%

Differential Survival of Penetrating and Lamellar Transplants in Management of Failed Corneal Grafts

et al. 2018

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IMPORTANCE An increasing proportion of corneal transplant procedures are undertaken for replacement of a failed previous graft. The proportion of lamellar transplant procedures has significantly increased. There are limited large-scale reports on regraft procedures that may help guide surgeons and patients in their choice of surgery. OBJECTIVE To examine the corneal transplant replacement survival rates for the 3 main indications and types of regraft surgery.

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Section: Methodsmentioning

confidence: 99%

Differential Survival of Penetrating and Lamellar Transplants in Management of Failed Corneal Grafts

et al. 2018

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“…However, corneal graft rejections and failures are common, reported to be 15–18% in full-thickness grafts and 4–9% in posterior lamellar grafts, during 10 years of follow-up [ 2 ]. Immunological inflammation may contribute some risk to the overall reported five-year graft survival of 71% (95% CI: 69–73%) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients

Achiron

Yahalomi

Hecht

et al. 2022

Journal of Ophthalmology

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Purpose. It is controversial whether donor-recipient sex mismatch is a risk factor associated with corneal graft failure. The purpose of this study was to investigate the effect of sex mismatch on corneal graft failure in high-risk and non-high-risk patients. Design. A retrospective study. Methods. The medical charts of patients who underwent corneal transplantations by one surgeon between 2012 and 2017 were reviewed. Patients were defined as high-risk for failure if they had glaucoma, ocular surface disease, or corneal vascularization. Graft failure rates were compared using the Kaplan–Meier survival curves between sex matched and mismatched subjects and between male-to-female grafting and other patients. Results. One hundred and thirteen patients with a minimum follow-up of 18 months were included. In 62 non-high-risk patients, graft failure rates were similar between the sex mismatched and the sex matched recipients ( p = 0.645 , log-rank) and in male donor to female recipient transplantations and in the other transplantations ( p = 0.496 , log-rank). Analysis of fifty-one eyes of 51 high-risk graft recipients (mean age of 73.4 ± 12.7 years, N = 26 females) showed that graft failure rates were significantly higher in the sex mismatched than sex matched recipients ( p = 0.022 , log-rank) and in male donor to female recipient transplantations than in the other transplantations ( p = 0.002 , log-rank). Conclusions. Sex matching for every patient bares logistic difficulties; however, in patients who are at high-risk for graft failure, it may be a simple way to improve outcomes and better utilize corneal grafts.

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“…Delaying surgery by management with a bandage contact lens until subsidence of inflammation allowed for a more controlled setting and elective as opposed to tectonic therapeutic pdDALK. Keratoplasty in an acutely inflamed eye – besides other known risk factors like corneal neovascularization, young recipient age, repeat corneal transplants, and gender mismatch – is associated with decreased long-term graft survival [ 15 – 18 ]. Intraoperatively the perforation site was plugged by iris strands with surrounding anterior synechiae, which allowed for anterior chamber stability during LD.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative management of macroperforations of Descemet’s membrane in deep anterior lamellar keratoplasty

Steger

Romano

Palme

et al. 2016

Spektrum Augenheilkd.

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SummaryBackgroundTo describe a surgical approach for the completion of pre-descemetic deep anterior lamellar keratoplasty (pdDALK) in the presence of a macroperforation of Descemet’s membrane (DM).MethodsUsing case notes, we recorded the details of the intra- and perioperative course of patients who underwent successful pdDALK in the presence of macroperforation. A literature search of pdDALK techniques available to the corneal surgeon in a similar scenario was undertaken.ResultsIn two very different scenarios with intra- or preoperative perforation of DM, a centripetal layered lamellar dissection was performed and allowed completion of pdDALK with a residual recipient central stromal thickness of 36 and 115 µm and good visual outcome.ConclusionDespite very different scenarios, a centripetal layered lamellar dissection offers an approach for the completion of pdDALK in the presence of a macroperforation.

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Sequential Bilateral Corneal Transplantation and Graft Survival

Cited by 18 publications

References 32 publications

Differential Survival of Penetrating and Lamellar Transplants in Management of Failed Corneal Grafts

Differential Survival of Penetrating and Lamellar Transplants in Management of Failed Corneal Grafts

Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients

Intraoperative management of macroperforations of Descemet’s membrane in deep anterior lamellar keratoplasty

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