1997
DOI: 10.1001/archderm.133.7.919
|View full text |Cite
|
Sign up to set email alerts
|

Sequences of human herpesvirus 8 are not detected in various non-Kaposi sarcoma vascular lesions

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
18
0

Year Published

2000
2000
2018
2018

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(19 citation statements)
references
References 0 publications
1
18
0
Order By: Relevance
“…The great majority of non-Kaposi sarcoma vascular tumors previously studied have, however, been negative for HHV-8 by PCR. 16,[27][28][29][30][31][32][33] Given that the positive cases in the present study all showed levels above our preset high threshold level, we believe our results do indicate the true presence of HHV-8, rather than representing 'false positives'. Regrettably, we did not have access to frozen tissue from these positive cases, and thus were unable to perform Southern blot confirmation.…”
Section: Discussionmentioning
confidence: 67%
See 1 more Smart Citation
“…The great majority of non-Kaposi sarcoma vascular tumors previously studied have, however, been negative for HHV-8 by PCR. 16,[27][28][29][30][31][32][33] Given that the positive cases in the present study all showed levels above our preset high threshold level, we believe our results do indicate the true presence of HHV-8, rather than representing 'false positives'. Regrettably, we did not have access to frozen tissue from these positive cases, and thus were unable to perform Southern blot confirmation.…”
Section: Discussionmentioning
confidence: 67%
“…26 Our finding of uniform HHV-8 expression in Kaposi sarcoma, by PCR, is in agreement with numerous prior studies, all of which have found 490% of Kaposi sarcoma of all types to be HHV-8 positive, using both traditional and in situ PCR. 16,[27][28][29][30][31][32][33] The 100% detection rate we observed may in part be due to our use of a high cycles-tothreshold limit of 50. We chose to carry reactions out to 50 cycles-to-threshold for the purpose of detecting potentially very low viral loads in paraffinembedded tissue blocks that had been in storage for up to 10 years.…”
Section: Discussionmentioning
confidence: 99%
“…HHV-8 DNA can be detected in normal skin of HIV-infected patients with KS 62,64,98 , and in normal skin from patients with endemic KS 12,15,65,99,100 , or in iatrogenic KS 101 . It is also found in lesional tissue of patients with squamous cell or basal cell carcinomas 66 .…”
Section: Other Conditionsmentioning
confidence: 99%
“…An association has been suggested between angiosarcoma and oncoviruses, such as HHV-8, following detection of a viral sequence in the DNA of a primary angiosarcoma [17]. This association remains controversial, as others have failed to detect similar sequences in either primary [18] or in post-transplant angiosarcoma [19]. In a series of 3 patients with PTLD reported by Webster et al, 2 of the patients have PTLD as well as angiosarcoma [16].…”
Section: Discussionmentioning
confidence: 99%