Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization

Satoh, Kotaro; Ozawa, Shoji; Mizutani, Masato; Nagai, Kanji; Kamigaito, Masami

doi:10.1038/ncomms1004

Cited by 223 publications

(171 citation statements)

References 30 publications

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“…Kamigaito and coworkers used a metal catalyzed stepgrowth radical polyaddition to obtain sequence regulated vinyl copolymers, consisting of styrene, acrylate, and vinyl chloride units. [21] The resulting segmented polymers had within each segment a defined ABCC-sequence of vinyl chloride-styrene-acrylate-acrylate monomers. Lutz et al suggested a highly innovative strategy to establish positional control of functional entities within linear high-molecular-weight polymers.…”

Section: Detours Via Monomer Sequence-controlled Polymersmentioning

confidence: 99%

Precision Polymers—Modern Tools to Understand and Program Macromolecular Interactions

Börner

2010

Macromol. Rapid Commun.

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AB-block copolymers composed of a common synthetic polymer part and a monodisperse, monomer sequence-defined segment are considered belonging to the class of "Precision Polymers." This overview summarizes the possibilities that arise from those precisely adjustable, functional polymers for materials science applications. The freely programmable monomer sequence of the discrete peptide segment allows adjusting properties such as interaction capabilities. This can be exploited to (i) specifically solubilize and transport low molecular weight drugs, (ii) to pack DNA, (iii) to direct crystallization, or (iv) to modulate adhesion behavior of cells on material surfaces. As evident from proteins, the room to improve the precision of synthetic macromolecules will offer plenty of opportunities.

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Section: Detours Via Monomer Sequence-controlled Polymersmentioning

confidence: 99%

Precision Polymers—Modern Tools to Understand and Program Macromolecular Interactions

Börner

2010

Macromol. Rapid Commun.

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“…[5,13,15,20,[22][23][24][25][26][27][28][29][30][31][32] In particular, a few research groups investigated sequence-regulation in chaingrowths polymerizations. For instance, the innovative approaches recently reported by the research groups of Sawamoto, [26,29,32,33] Thomas, [10,27] and Kamigaito [20,30] have to be mentioned. In parallel, our research group studied the controlled radical chain-growth copolymerization of ultra reactive comonomers.…”

Section: Introductionmentioning

confidence: 99%

Tailored Polymer Microstructures Prepared by Atom Transfer Radical Copolymerization of Styrene and N‐substituted Maleimides

Lutz¹,

Schmidt²,

Pfeifer³

2011

Macromol. Rapid Commun.

132

124

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In the present Feature Article, a kinetic strategy for controlling the microstructure of synthetic polymer chains prepared via a radical chain‐growth polymerization process is presented. This approach was recently developed in our laboratory and relies on the controlled kinetic addition of ultrareactive N‐substituted maleimides during the atom transfer radical polymerization of styrene. This method is experimentally straightforward and can be applied to a broad library of functional N‐substituted maleimides. Thus, this platform allows synthesis of unprecedented polymer materials such as 1D macromolecular arrays. The basic kinetic requirements, the experimental conditions, and the synthetic scope of this approach are discussed in details herein. magnified image

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“…Nature's precision in regulating monomer sequences also remains unmatched in non-natural macromolecules [6][7][8][9][10] . Among the various examples of sequence-regulated synthetic macromolecules, block copolymers exhibiting a large number and type of functional sequences -that is, multiblock copolymers-are unique and original structures that exhibit a type of primary structure (although the sequence control is typically limited by the monomer distribution within each block).…”

mentioning

confidence: 99%

Rapid and quantitative one-pot synthesis of sequence-controlled polymers by radical polymerization

et al. 2013

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A long-standing challenge in polymer chemistry has been to prepare synthetic polymers with not only well-defined molecular weight, but also precisely controlled microstructure in terms of the distribution of monomeric units along the chain. Here we describe a simple and scalable method that enables the synthesis of sequence-controlled multiblock copolymers with precisely defined high-order structures, covering a wide range of functional groups. We develop a one-pot, multistep sequential polymerization process with yields 499%, giving access to a wide range of such multifunctional multiblock copolymers. To illustrate the enormous potential of this approach, we describe the synthesis of a dodecablock copolymer, a functional hexablock copolymer and an icosablock (20 blocks) copolymer, which represents the largest number of blocks seen to date, all of very narrow molecular weight distribution for such complex structures. We believe this approach paves the way to the design and synthesis of a new generation of synthetic polymers.

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Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization

Cited by 223 publications

References 30 publications

Precision Polymers—Modern Tools to Understand and Program Macromolecular Interactions

Precision Polymers—Modern Tools to Understand and Program Macromolecular Interactions

Tailored Polymer Microstructures Prepared by Atom Transfer Radical Copolymerization of Styrene and N‐substituted Maleimides

Rapid and quantitative one-pot synthesis of sequence-controlled polymers by radical polymerization

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