Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
28
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 25 publications
(29 citation statements)
references
References 24 publications
1
28
0
Order By: Relevance
“…Alignment of human to zebrafish At3 reveals 55% identity and 70% similarity (supplemental Figure 2 and Kumar et al 62 ). Because human AT3 rescued the prolonged time to occlusion in our endothelial injury assay, we performed semiquantitative evaluation of various human mutations and targeted substitutions.…”
Section: Discussionmentioning
confidence: 98%
“…Alignment of human to zebrafish At3 reveals 55% identity and 70% similarity (supplemental Figure 2 and Kumar et al 62 ). Because human AT3 rescued the prolonged time to occlusion in our endothelial injury assay, we performed semiquantitative evaluation of various human mutations and targeted substitutions.…”
Section: Discussionmentioning
confidence: 98%
“…Group U1 serpins have five introns at positions 67a, 136b, 191c, 246a and 274a (missing in Ci-Spn-1). These intron positions are based on amino acid numbering of mature (without signal peptide) human A1AT, followed by intron phasing with suffixes a-c as reported in previous studies 5, 9. Two of these introns (at the positions 67c and 191c) are shared with vertebrate groups V4 and V5, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Serpins are single domain proteins with an average size: 350-400 amino acids and molecular weights of 40-60 kDa 2-4. These proteins are classified into two functional categories - inhibitory (majority) such as antithrombin III 5, while some of them are non-inhibitory, which adopt other function than inhibitory roles such as angiotensinogen, which lost inhibition during vertebrate evolution 6. Serpins are thought to have evolved through gene duplication and divergence events, giving rise to a large number of serpin genes within an organism, each encoding a protein with a unique reactive center region and physiological function(s) 7.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to known procoagulant effectors of the blood clotting system, zebrafish also express conserved natural anticoagulant factors, including antithrombin III (At3) [44, 45••]. Targeted ablation of at3 using ZFNs was followed by spontaneous intracardiac thrombi with a variable range of lethality in adulthood [45••].…”
Section: Conservation Of the Coagulation Cascade In Zebrafishmentioning
confidence: 99%