Sequence of histological changes in the uterus and vagina of the rat during prologation of pseudopregnancy associated with the presence of deciduomata

Velardo, Joseph T.; Dawson, Alden B.; Olsen, Ambre L.; Hisaw, Frederick L.

doi:10.1002/aja.1000930205

Cited by 69 publications

(18 citation statements)

References 13 publications

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“…106 This response elicits the formation of a deciduomata that is very similar (albeit not identical 107 ) to true decidua. Extensive observations based on this model have confirmed that the pseudo-decidual reaction is followed by the involution of the anti-mesometrial region 108 and preceded by the degradation of the luminal epithelium (in the rat, 109 in the mouse 110,111 ). Epithelial cells in the antimesometrial zone seem to detach progressively from the basal lamina and show clear signs of degradation (condensation and margination of the nuclear chromatin and dilation of the endoplasmic reticulum) which resemble those detected during normal implantation.…”

Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 69%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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The aim of this review is to summarize the information currently available regarding the occurrence of apoptosis in the developing embryo and in the receptive uterus during the peri-implantation period of gestation. Cell death is detected in the inner cell mass of late pre-implantation embryos as the result of an eliminative process that helps trim the embryonic cell lineages of surplus or dysfunctional stem cells. Cell death is also detected in the epiblastic core of early postimplantation embryos, where the process is implicated in the formation of the pro-amniotic cavity. On the maternal side, uterine epithelial cells situated around the attachment site undergo cell death during the initial phase of implantation in order to facilitate embryo anchorage and access to maternal blood supply. Uterine stromal cells closest to the implantation chamber first transform into decidual cells and then commit suicide to make room for the rapidly growing embryo. Although apoptosis is well recognized as a crucial determinant of successful peri-implantation development, our understanding of the cellular and molecular mechanisms regulating this process clearly lags behind the comprehension of cell death control in other systems.

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Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 69%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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“…Such orientation would appear to be essential for normal placental development and for the coordination of events that eventually free the embryo from the confines of the decidua and later from the uterus. Although chamber formation occurs to a limited extent in deciduoma [Krehbiel, 1937;Velardo et al, 1953;O'Shea et al, 19831, indicating that it is partly an intrinsic prop- erty of decidua formation and not just a result of the embryo occupying the space, the formation of a chamber in normal pregnancy probably requires an interaction between the stroma and the conceptus.…”

Section: U~s 11-16mentioning

confidence: 97%

Light and electron microscopic examination of the mature decidual cells of the rat with emphasis on the antimesometrial decidua and its degeneration

1985

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Rat gestation sites were obtained on days 10 through 16 of normal pregnancy. Light and electron microscopic examination of day-10 sites revealed a consistent complex pattern of stromal cell morphologies. Six distinct regions were identified: an antimesometrial region of epithelioid decidual cells that form the gestation chamber containing the embryo and extraembryonic membranes; an abembryonic antimesometrial decidual region, the decidual crypt, where the cells are separated by large extracellular spaces; a mesometrial region with granule-containing cells and mesometrial decidual cells; a region of spiny cells that are lateral to the antimesometrial decidual cells and continuous with the mesometrial decidual cells; and a region of undifferentiated stromal cells adjacent to the myometrium. Between days 12 and 16, the antimesometrial decidua becomes thinner and is eventually sloughed into the newly formed uterine lumen. The role of the antimesometrial decidual cells is discussed with reference to trophoblast invasiveness, protein synthesis, and especially remodeling of the gestation chamber. Differences between decidua and deciduoma are considered.

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“…They have been shown to contain glycogen (Bridgman, 1948), and their cytoplasmic granules are characterized by a diastase-fast periodic acid-Schiff reaction (Wislocki, Weiss, Burgos & Ellis, 1957) and a high content ofacid hydrolases (Bulmer, 1968). A variety of functions has been attributed to them, including the provision of nutrient to the developing embryo (Selye & McKeown, 1935), the liberation of a holocrine secretion facilitating disruption of the muscle coat during the expansion of the uterine wall (Bloch, 1964), and the production of relaxin (Velardo, Dawson, Olsen & Hisaw, 1953;Dallenbach-Hellweg, Battista & Dallenbach, 1965); none of these, however, has been proven or considered generally acceptable.…”

mentioning

confidence: 99%