Sequence differentiation between some DNA regions of Hintonia latiflora and Hintonia standleyana

Stranczinger, Sz.; Szentpéteri, József; Borhidi, A.

doi:10.1556/abot.48.2006.3-4.16

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…55 H. latif lora and H. standleyana are endemic to Mexico and Northern Guatemala. 56 Many authors have treated H. standleyana as a synonym of H. latif lora. 57 However, morphological and molecular studies have demonstrated recently that the two plants should be recognized within the genus Hintonia as independent species.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Thus, these findings provide genetic support for the segregation of the two Hintonia taxa. 56,58 In modern day Mexico, H. latif lora is used for the treatment of gastritis, urinary infections, pain, malaria, and diabetes. 15,16 Owing to its antidiabetic effect, Mexican and several European drug companies have commercialized herbal products containing the stem bark of H. latif lora for more than nine decades.…”

Section: ■ Introductionmentioning

confidence: 99%

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Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

et al. 2013

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Type II-diabetes mellitus (TII-DM) has been regarded as one of the most important public health problems in all nations in the 21st century. Although allopathic therapies remain the most important for the initial management of TII-DM, herbal remedies have gained wide acceptance for treating this condition. These alternative therapies are particularly valued in countries such as Mexico, rich in medicinal plants strongly attached to the cultural values of the population. Medicinal plants are prized sources of α-glucosidase inhibitors, which delay the liberation of glucose from complex carbohydrates, retarding glucose absorption, and thus controlling the characteristic hyperglycemia of TII-DM. Among the plant species used for treating diabetes in Mexico only 38 have been analyzed for their inhibitory activity of α-glucosidases. Most of these studies, reviewed in the present work, have focused on the evaluation of different types of extracts on the activity of α-glucosidases from diverse sources. Four species have been thoroughly analyzed in order to discover novel α-glucosidase inhibitors, namely, Hintonia latiflora and Hintonia standleyana (Rubiaceae), Ligusticum porteri (Apiaceae), and Brickellia cavanillesii (Asteraceae). Their ethnomedical uses, pharmacological and toxicological studies, chemical composition, and antihyperglycemic principles with α-glucosidase inhibitory activity are summarized.

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Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

et al. 2013

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“…Borhidi (2006) no reconoce a la variedad leiantha y sí considera a H. standleyana como una especie distinta; añade la pubescencia del cáliz y de las hojas como características diferenciales. Resalta el desconocimiento del número cromosómico básico de H. latiflora (Kiehn, 1995), pero existen algunas evidencias moleculares que apoyan la separación de las especies (Stranczinger et al, 2006), como son las secuencias de ADN de H. latiflora con diferentes números de acceso en el GenBank (Manss y Bremer,200).…”

Section: Resultsunclassified

Historia natural y cosecha de corteza de quina amarilla Hintonia latiflora (Rubiaceae)

et al. 2015

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<p>Hintonia latiflora (Sessé & Moc. ex DC.) Bullock, la “quina amarilla”, es un árbol americano propio del bosque tropical caducifolio, valioso, debido a que la corteza tiene propiedades medicinales. La principal zona de abasto comercial de quina amarilla está al norte del estado de Guerrero, México. Esta contribución aporta información bibliográfica en torno a la historia natural y del aprovechamiento de <em>H. latiflora</em> en toda su área de distribución. Además, incorpora datos de campo originales acerca del hábitat, densidad, fenología, dispersión, arquitectura, comercialización e intensidad en el aprovechamiento de algunas poblaciones de quina amarilla de la cuenca alta del Río Balsas. Se encontraron factores biofísicos importantes para el establecimiento, crecimiento y supervivencia de la especie. La fenología consiste en la floración en la primavera-verano, foliación en el verano, fructificación a finales del verano y dispersión durante el invierno. La dispersión es anemócora y barócora. La arquitectura arbórea se relaciona con factores ambientales y la cosecha de corteza. Se observó que la densidad y disponibilidad de la especie cambian con las características de los sitios y con la intensidad de recolección. La comercialización de la quina implica a tres actores: los recolectores, los acopiadores locales y los compradores regionales. Los precios históricos de la corteza al consumidor han aumentado pero al considerar los precios sin inflación, realmente han bajado. Se destaca que la mayor amenaza para las poblaciones es la intensidad de aprovechamiento y la práctica descuidada de la cosecha.</p>

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“…The phylogenetic approach generates a tree that clearly separates the three Rubiaceae species that conforms the copalchi complex: H. latiflora, H. standleyana , and E. caribaeum ; the concatenated trnH-psbA, rpl32-trnL , and ITS2 sequence reinforce the molecular evidence in order to recognize H. latiflora and H. standleyana as two different taxa (Borhidi and Diego-Pérez, 2002 ; Stranczinger et al, 2006 ). The approach of species identification with a Maximum Likelihood tree profile does not necessarily depend on the barcoding gap but on the coalescence of conspecific populations and the monophyly of species (Wiemers and Fiedler, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…and C. reflexifolius Kunth. Also, there is a taxonomical disagreement about the identity of H. standleyana ; some authors recognizes the existence of H. standleyana as a taxon (Borhidi and Diego-Pérez, 2002 ; Stranczinger et al, 2006 ); where as other specialists state that this species is a synonym of H. latiflora (Ochoterena-Booth, 2000 ; Motley et al, 2005 ; Martínez-Cabrera et al, 2014 ); morphological and molecular data were analized in both cases but chemical analysis was never used for clarify this taxonomical ambiguity.…”

Section: Introductionmentioning

confidence: 99%

Molecular Markers Associated With Chemical Analysis: A Powerful Tool for Quality Control Assessment of Copalchi Medicinal Plant Complex

2018

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The copalchi complex, Hintonia latiflora, H. standleyana, and Exostema caribaeum, is widely used in Mexico for treating diabetes and gastrointestinal disorders. The first therapeutic use for H. latiflora bark was registered in the “Florentine Codex” in the sixteenth century. The latest pharmacological and phytochemical studies revealed that the infusion of the leaves have hypoglycemic, antihyperglycemic and gastroprotective activities. For these reasons the monograph of the main copalchi species, H. latiflora, was recently added to the Mexican Herbal Pharmacopoeia. Nevertheless, quality control parameters are focused to the bark but not to the leaves. Moreover, information about other Rubiaceae species is needed. The main goal of this study was to generate molecular and chemical markers for quality control of the copalchi complex raw material. In addition, the resolution of the taxonomical ambiguity between H. latiflora and H. standleyana, as well as the testing of the molecular and chemical markers in different geographical batches, were aims of this study. The molecular markers and chemical profiles of the leaf infusions were generated considering three different populations for H. latiflora and separate individuals of the three species (HL, n = 10; HS, n = 3; EC, n = 4). The molecular markers matK, rbcL, trnH-psbA, rpl32-trnL, and ITS2 were tested for their discriminating capabilities. Chemical profiles of the leaf infusions were obtained by means of HPLC analyses using chlorogenic acid and 4-phenylcoumarins as chemical markers. The concatenated sequence of the molecular markers trnH-psbA, rpl32-trnL, and ITS2 clearly distinguished the three taxa, clarifying the taxonomical ambiguity of the Hintonia genus. Additionally, the chemical profiles allowed the unequivocal identification of each species supporting the molecular results; the geographical origin of the samples did not modify neither the chemical profiles nor the concatenated sequence of H. latiflora, suggesting that it is a robust identity test. The complementary use of molecular and chemical markers will assure the quality of plant material used in traditional medicine for therapeutic purposes, and should be valuable new information for the National Health authorities as a part of the Mexican Herbal Pharmacopoeia.

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Sequence differentiation between some DNA regions of Hintonia latiflora and Hintonia standleyana

Cited by 5 publications

References 6 publications

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

Historia natural y cosecha de corteza de quina amarilla Hintonia latiflora (Rubiaceae)

Molecular Markers Associated With Chemical Analysis: A Powerful Tool for Quality Control Assessment of Copalchi Medicinal Plant Complex

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