Sepsis is Characterized by the Increases in Percentages of Circulating CD4+CD25+ Regulatory T Cells and Plasma Levels of Soluble CD25

“…As an important regulator of the immune system, Treg plays a major inhibitory effect on cellular immunity in the complicated cellular immune regulation network [20]. The CD4 + CD25 + Treg participates in the induction of lymphocyte anergy, which is an important part of immune suppression.…”

Section: Discussionmentioning

confidence: 99%

The influence of Th1/Th2 and CD4 + regulatory t cells of mesenteric lymph nodes on systemic lipopolysaccharide

Du²,

Fu³

et al. 2014

pjp

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Our aims were to study the influence of the mesenteric lymph nodes (MLN) of rats on systemic lipopolysaccharide and to identify the factor that affects the intestinal endotoxin translocation. Ninety-six male Wistar rats were randomly divided into a sham-operation group (S group) and a cecal ligation and perforation group (CLP group). Twenty-four hours after modeling, we tested the Th1/Th2 ratio and percentage of CD4+ Treg in the MLN. At the same time, the lipopolysaccharide (LPS) in the abdominal aortic blood was detected. In the CLP group, the Th1/Th2 ratio was obviously lower than in the S group. Otherwise, the percentage of CD4+ Treg of the CLP group was significantly higher than the S group. In the abdominal aortic blood, the LPS level of the CLP group was also higher than in the S group. Through correlation analysis, we found that the level of LPS was positively correlated with the percentage of CD4 + CD25 + Foxp3+ Treg, and negatively correlated with the Th1/Th2 ratio. This model reveals that the immune suppression of the MLN might affect the level of LPS in the abdominal aortic blood, which might play a certain role in affecting the endotoxin translocation. Foxp3+ Treg, Th1/Th2 ratio.

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“…Tregs higher in sepsis compared to SIRS [38] No difference on Treg kinetics and absolute numbers between SIRS and sepsis [39] 795…”

Section: Regulatory T Cells (Tregs)mentioning

confidence: 99%

Biomarkers for the differentiation of sepsis and SIRS: the need for the standardisation of diagnostic studies

et al. 2011

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Sepsis is Characterized by the Increases in Percentages of Circulating CD4+CD25+ Regulatory T Cells and Plasma Levels of Soluble CD25

Cited by 51 publications

References 32 publications

The role of T regulatory cells in human sepsis

The role of T regulatory cells in human sepsis

The influence of Th1/Th2 and CD4 + regulatory t cells of mesenteric lymph nodes on systemic lipopolysaccharide

Biomarkers for the differentiation of sepsis and SIRS: the need for the standardisation of diagnostic studies

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