Sepsis in Leukemia and the Shwartzman Reaction

‘Hypercoagulable State’ in Children with Acute Leukemia or Disseminated Solid Tumors

“…'Hypercoagulable state' is said to exist when there are supernormal levels of consumable factors along with shortened partial thromboplastin time. Most of our patients with acute leukemia and all children with disseminated solid tumors had this 'hypercoagulable state', thus confirming previous studies [2,4,6,7], Factor VIII levels were also found to be increased in adults with acute myeloblastic leukemia [5,7].…”

“…Indeed, different authors have even some conflicting reports, varying from 'hypercoagulable state', acquired coagulation factor deficiencies [1], DIC, fibrinolysis secondary to DIC, and in some cases primary fibrinolysis. The occurrence of 'hypercoagulable state' has been documented in dissem inated malignancies in adults [2][3][4][5], but reports of its occurrence in children are fragmentary [6], We assayed coagulation factors in children with acute leukemia in relapse or with disseminated solid tumors and tried to define any uniform pattern of abnormalities. …”

‘Hypercoagulable State’ in Children with Acute Leukemia or Disseminated Solid Tumors

“…'Hypercoagulable state' is said to exist when there are supernormal levels of consumable factors along with shortened partial thromboplastin time. Most of our patients with acute leukemia and all children with disseminated solid tumors had this 'hypercoagulable state', thus confirming previous studies [2,4,6,7], Factor VIII levels were also found to be increased in adults with acute myeloblastic leukemia [5,7].…”

“…Indeed, different authors have even some conflicting reports, varying from 'hypercoagulable state', acquired coagulation factor deficiencies [1], DIC, fibrinolysis secondary to DIC, and in some cases primary fibrinolysis. The occurrence of 'hypercoagulable state' has been documented in dissem inated malignancies in adults [2][3][4][5], but reports of its occurrence in children are fragmentary [6], We assayed coagulation factors in children with acute leukemia in relapse or with disseminated solid tumors and tried to define any uniform pattern of abnormalities. …”

Evaluation of procoagulant activity production and other coagulative functions in cancer patients receiving acid treated Salmonella minnesota R 595 (Re)

“…Neither were significant differences seen in PCA with increasing doses of Salmonella minnesota Re. Moreover, D i e does not often occur in patients with gramnegative sepsis complicating acute leukemia and leukopenic states (15). 4,1988 Clotting function and Salmonella immunotherapy in cancer patients.…”

Infection-Induced Thrombocytopenia

“…Many case reports have described DIC complicating septicemia. 47,61,75,82,99,105,120,126,157,161,163,169,173,204 However, thrombocytopenia has also been reported to occur without laboratory evidence of DIC. 10,33,39,40,43,76,101,134,144,150,166 This might reflect the relative insensitivity of the diagnostic tests used to detect DIC.…”

‘Hypercoagulable State’ in Children with Acute Leukemia or Disseminated Solid Tumors

“…'Hypercoagulable state' is said to exist when there are supernormal levels of consumable factors along with shortened partial thromboplastin time. Most of our patients with acute leukemia and all children with disseminated solid tumors had this 'hypercoagulable state', thus confirming previous studies [2,4,6,7], Factor VIII levels were also found to be increased in adults with acute myeloblastic leukemia [5,7].…”

“…Indeed, different authors have even some conflicting reports, varying from 'hypercoagulable state', acquired coagulation factor deficiencies [1], DIC, fibrinolysis secondary to DIC, and in some cases primary fibrinolysis. The occurrence of 'hypercoagulable state' has been documented in dissem inated malignancies in adults [2][3][4][5], but reports of its occurrence in children are fragmentary [6], We assayed coagulation factors in children with acute leukemia in relapse or with disseminated solid tumors and tried to define any uniform pattern of abnormalities. …”

Evaluation of procoagulant activity production and other coagulative functions in cancer patients receiving acid treated Salmonella minnesota R 595 (Re)

“…Neither were significant differences seen in PCA with increasing doses of Salmonella minnesota Re. Moreover, D i e does not often occur in patients with gramnegative sepsis complicating acute leukemia and leukopenic states (15). 4,1988 Clotting function and Salmonella immunotherapy in cancer patients.…”

Infection-Induced Thrombocytopenia

“…Many case reports have described DIC complicating septicemia. 47,61,75,82,99,105,120,126,157,161,163,169,173,204 However, thrombocytopenia has also been reported to occur without laboratory evidence of DIC. 10,33,39,40,43,76,101,134,144,150,166 This might reflect the relative insensitivity of the diagnostic tests used to detect DIC.…”

‘Hypercoagulable State’ in Children with Acute Leukemia or Disseminated Solid Tumors

“…'Hypercoagulable state' is said to exist when there are supernormal levels of consumable factors along with shortened partial thromboplastin time. Most of our patients with acute leukemia and all children with disseminated solid tumors had this 'hypercoagulable state', thus confirming previous studies [2,4,6,7], Factor VIII levels were also found to be increased in adults with acute myeloblastic leukemia [5,7].…”

“…Indeed, different authors have even some conflicting reports, varying from 'hypercoagulable state', acquired coagulation factor deficiencies [1], DIC, fibrinolysis secondary to DIC, and in some cases primary fibrinolysis. The occurrence of 'hypercoagulable state' has been documented in dissem inated malignancies in adults [2][3][4][5], but reports of its occurrence in children are fragmentary [6], We assayed coagulation factors in children with acute leukemia in relapse or with disseminated solid tumors and tried to define any uniform pattern of abnormalities. …”

Evaluation of procoagulant activity production and other coagulative functions in cancer patients receiving acid treated Salmonella minnesota R 595 (Re)

“…Neither were significant differences seen in PCA with increasing doses of Salmonella minnesota Re. Moreover, D i e does not often occur in patients with gramnegative sepsis complicating acute leukemia and leukopenic states (15). 4,1988 Clotting function and Salmonella immunotherapy in cancer patients.…”

Infection-Induced Thrombocytopenia

“…Many case reports have described DIC complicating septicemia. 47,61,75,82,99,105,120,126,157,161,163,169,173,204 However, thrombocytopenia has also been reported to occur without laboratory evidence of DIC. 10,33,39,40,43,76,101,134,144,150,166 This might reflect the relative insensitivity of the diagnostic tests used to detect DIC.…”