Biochemical Pharmacology volume 76, issue 11, P1383-1388 2008 DOI: 10.1016/j.bcp.2008.09.017 View full text
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P.A. Ward

Abstract: AbstractProgrammed cell death (apoptosis) is a prominent feature in human and experimental sepsis, especially as it involves the lymphoid system with resulting immunoparalysis. In addition, sepsis is associated with strong activation of the complement system, resulting in generation of the powerful anaphylatoxin, C5a, as well as the upregulation of the C5a receptor (C5aR) in a variety of different organs. The consequences of C5a interactions with C5aR can be directly linked to apoptosis of thymocytes and adre…

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