Sepsis and Myocardial Depression in a Young Woman

Subla, Mir Rauf; Khan, Shakila; Behl, Deepti; Peters, Steve G.

doi:10.4065/80.6.810

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…Sepsis‐induced myocardial depression (SIMD) in people is primarily a clinical diagnosis and relies on transthoracic echocardiography. Classic echocardiographic evidence of SIMD includes biventricular dilatation and reduced EF associated with a clinical syndrome of sepsis 27. Parker and her colleague showed, along with recovery from sepsis, myocardial depression resolves within 7–10 days.…”

Section: Discussionmentioning

confidence: 99%

Myocardial depression in a calf with septic shock

Naseri

Turgut

Şen

et al. 2018

Vet Record Case Reports

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A 10-day-old, 32-kg Simmental heifer calf was presented with a 2-day history of diarrhoea and anorexia. The diagnosis of septic shock was based on the presence of severe sepsis and hypotension that could not be reversed with fluid resuscitation. Echocardiographic findings included a hypokinetic left ventricle with decreased left ventricle ejection fraction, stroke volume and cardiac index. The end-systolic volume index (ESVI) was elevated to 36.14 ml/m2 and a depressed end-diastolic volume index (EDVI) (51.31 ml/m2). Left ventricular depression was normalised 24 hours after resuscitation. It was concluded that myocardial depression could be reversible in the calf with septic shock; however, according to the postresuscitation echocardiographic findings, a decreased ESVI suggests vasomotor dysregulation and a decreased EDVI suggests alterations in vascular permeability. These were the major implications of sepsis and resulted in multiple organ dysfunction and death.

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Section: Discussionmentioning

confidence: 99%

Myocardial depression in a calf with septic shock

Naseri

Turgut

Şen

et al. 2018

Vet Record Case Reports

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“…SiMD is a well-known complication of sepsis in people (Nelson and Thompson, 2006;Dickinson et al, 2007). Reversible SiMD has been recognised in 20 to 60% of humans with sepsis (Martin et al, 2005;Subla et al, 2005;Vieillard-Baron, 2011). However, studies concerning SiMD in dogs are limited and the effect of SiMD on the prognosis in dogs is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Prognostic importance of tissue Doppler imaging of systolic and diastolic functions in dogs with severe sepsis and septic shock

Ince

Turgut

Akar

et al. 2019

Acta Veterinaria Hungarica

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The goal of this study was to determine the distribution of left ventricular (LV) systolic and diastolic dysfunctions and their prognostic value in canine parvovirus-infected dogs suffering from severe sepsis and septic shock (SS/SS). Twenty dogs with SS/SS (experimental group) and 18 healthy dogs (control group) were used in the study. Systolic and diastolic dysfunction was present in three (15%) and 14 (70%) diseased dogs, respectively, with both types of dysfunction present in two (10%) of the patients. These dogs were split into two groups: survivors (Sv, n = 14) and non-survivors (non-Sv, n = 6). The pulsed wave tissue Doppler (PW-TDI) septal mitral annulus systolic velocity (LVS'), an index of systolic dysfunction, had a high sensitivity and specificity to differentiate Sv and non-Sv animals, with values of 83.3% (95% CI: 41.6–98.4) and 83.3% (95% CI: 59.8–94.8), respectively, at an optimum cut-off point of ≥ 9.90. The PW-TDI septal early mitral annulus early-diastolic peak velocity (E'), an index of diastolic dysfunction, had the best sensitivity and specificity to differentiate Sv and non-Sv dogs, with values of 100% (95% CI: 55.2–100) and 100% (95% CI: 78.9–100), respectively, at an optimum cut-off point of ≤ 6.50. Therefore, diastolic dysfunction determined by E' is a good independent outcome predictor.

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“…Several studies suggested that the relationship of vasoactive drug support to the degree of myocardial cell injury is attributable to the association of this support with disease severity, or it may be the cause of such injury [42,43,44]. …”

Section: Discussionmentioning

confidence: 99%

Are Electrocardiographic Changes in Patients with Acute Subarachnoid Hemorrhage Associated with Takotsubo Cardiomyopathy?

et al. 2009

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Background: Subarachnoid hemorrhage (SAH) has been associated with electrocardiographic (ECG) changes, arrhythmias, and release of cardiac enzymes. Recently, Takotsubo cardiomyopathies, presenting typical ECG changes and left ventricular (LV) regional wall-motion abnormalities (RWMAs), have been reported and considered to be a result of high norepinephrine (NE) levels. We hypothesized that ST-T-wave changes in patients with SAH may be manifestations of Takotsubo cardiomyopathy and associated with RWMAs. Methods: We instituted consecutive echocardiographic screening of all patients with acute aneurysmal SAH. A standard 12-lead ECG and blood samples for creatine kinase (CK) MB isoenzyme and troponin-T (Tn-T) were obtained. To evaluate sympathetic nervous activity, we obtained blood samples and urine samples for NE. Results: Of 42 patients with acute aneurysmal SAH, 26 had abnormal ECG including rhythm abnormalities. Ten of 12 patients with ST-T-wave changes had severe neurologic deficits, but 1 patient had RWMAs on echocardiography. Another patient with LV dysfunction showed a normal ST-T wave. In patients with ST-T-wave changes, elevated Tn-T (8.3 vs. 3.3%), CK-MB (8.3 vs. 10.0%), plasma and urine NE (16.7 and 33.3% vs. 16.7 and 50.0%), and mortality (8.3 vs. 13.3%) were not significantly higher. All 5 deaths resulted from noncardiac causes. High plasma and urine NE levels were not related to neurologic severity or mortality. Conclusions: Although ECG abnormalities are frequently seen in SAH patients, the incidence of RWMAs is very low. Electrocardiographic manifestations in patients with SAH and Takotsubo cardiomyopathy are similar, but ECG abnormalities in patients with SAH are mostly not related to LV dysfunction.

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Sepsis and Myocardial Depression in a Young Woman

Cited by 8 publications

References 39 publications

Myocardial depression in a calf with septic shock

Myocardial depression in a calf with septic shock

Prognostic importance of tissue Doppler imaging of systolic and diastolic functions in dogs with severe sepsis and septic shock

Are Electrocardiographic Changes in Patients with Acute Subarachnoid Hemorrhage Associated with Takotsubo Cardiomyopathy?

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