Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma

Liang, Hairui; Kays, Michael B.; Sowinski, Kevin M.

doi:10.1016/s1570-0232(02)00046-6

Cited by 167 publications

(174 citation statements)

References 27 publications

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“…Samples were stored at -20uC until they were analysed. Moxifloxacin concentration was determined by highperformance liquid chromatography with fluorescence detection as previously described [5]. The AUC24 was calculated according to the trapezoidal rule.…”

mentioning

confidence: 99%

Moxifloxacin in multidrug-resistant tuberculosis: is there any indication for therapeutic drug monitoring?: Table 1–

et al. 2012

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mentioning

confidence: 99%

Moxifloxacin in multidrug-resistant tuberculosis: is there any indication for therapeutic drug monitoring?: Table 1–

et al. 2012

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“…al. used SDS as ion pair reagent to separate fluoroquinolones in a mixture at pH 3.0 and found a concentration 10.0 mM to be optimum 74 . Band broadening and peak tailing is common with reverse phase chromatography for fluoroquinolones.…”

Section: Chromatographic Separationmentioning

confidence: 99%

“…Use of mobile phase having low pH protonates the amine functional group and the silanolic hydroxyl group and thereby reduces silanophilic interaction 75 . The same objective is achieved by using amine modifiers in the mobile phase [72][73][74][75] . The use of paired ion chromatographic reagents or competing base in the mobile phase is a common practice in most of the techniques reported.…”

Section: Chromatographic Separationmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:Fluoroquinolones are the most commonly prescribed synthetic antibacterial agents having improved pharmacokinetic properties and broad spectrum of activity. Due to their broad clinical activity they are the most promising drug for antibacterial chemotherapy. The current study focused on the application of similar chromatographic system for the analysis of a number of fluoroquinolones from bulk, pharmaceutical formulations and biological matrices. We have also summarized how a single chromatographic system can be used for the quantification of a number of fluoroquinoloes from their respective marketed formulation. A detailed systemic survey of the sample preparation techniques, the chromatographic conditions and detection of the respective fluoroquinolones has been presented in this study. In the course of this discussion the advantages and applicability of the high performance liquid chromatographic techniques are also examined.

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“…Thorough study of the literature reveals that several methods have been developed for the determination of fluoroquinolones in bulk, pharmaceutical dosage form and biological samples based on wide array of instru-ments like spectrophotometric [9][10][11], HPLC [12,13], capillary electrophoresis [14], electrochemical [15] and spectrofluorimetric [8,[16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Spectrofluorimetric Method for Determination of Fluoroquinolones through Charge-Transfer Complex Formation

Shah¹,

Jan²,

Ullah³

et al. 2013

AJAC

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A sensitive spectrofluorimetric method was developed for determination of ciprofloxacin (CPFX), levofloxacin (LEV), gatifloxacin (GAT) and moxifloxacin (MOX) in pure, commercial formulations, human urine and plasma. The method is based on charge-transfer (CT) complex with chloranilic acid. Fluorescence intensity of the complexes was measured at emission wavelength ranging from 445 -492 nm with excitation wavelengths from 285 -330 nm. At optimum experimental conditions, a linear calibration plot was obtained in the concentration range of 20 -1000 ng·mL , 20 -800 ng·mL −1 and 20 -100 ng·mL −1 for CPFX, LEV, MOX and GAT, respectively with good correlation coefficient in the range of 0.9929 -1.0 in methanolic medium. The limit of detection and limit of quantification were found to be 5 ng·mL −1 and 18 ng·mL −1 for CPFX, 12 ng·mL −1 and 40 ng·mL −1 for LEV, 8 ng·mL −1 and 19 ng·mL −1 for MOX, 6 ng·mL −1 and 19 ng·mL −1 for GAT, respectively. The method was found free of interferences from excipients used as additive in pharmaceutical preparations, some common cations and compounds present in urine and plasma as well as co-administered analgesic, vitamins and other drugs. The method was successfully applied for quantification of selected fluoroquinolones in commercial formulations and also in spiked human urine and plasma samples with percent recoveries of 100.0 ± 1.56 and 100.2 ± 1.29 respectively.

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Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma

Cited by 167 publications

References 27 publications

Moxifloxacin in multidrug-resistant tuberculosis: is there any indication for therapeutic drug monitoring?: Table 1–

Moxifloxacin in multidrug-resistant tuberculosis: is there any indication for therapeutic drug monitoring?: Table 1–

Untitled

Sensitive Spectrofluorimetric Method for Determination of Fluoroquinolones through Charge-Transfer Complex Formation

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