2010
DOI: 10.1007/s00421-010-1577-5
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Abstract: Combined heat stress, dehydration, and exercise is associated with enhanced oxidative stress in humans, but the separate and combined effects of heat stress and exercise on circulatory markers of oxidative stress without the influence of dehydration remain uncertain. The purpose of this study was to determine the effects of whole body heat stress alone and in combination with exercise on blood markers of oxidative stress in euhydrated humans. Eight males wore a water-perfused suit at rest and during 6 min of o… Show more

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Cited by 27 publications
(53 citation statements)
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“…Furthermore, increasing levels of isoprostanes has been considered as a sensitive marker of lipid peroxidation as it is a product of the free radical-oxidation of phospholipids and therefore reflects the extent of oxidative stress induced lipid peroxidation (Nieman et al 2002;Nikolaidis et al 2011). We have recently shown that heat stress, independent of dehydration, induces a disruption of the redox balance as well as a decrease in SOD activity in resting and exercising humans (Laitano et al 2010). However, the contribution of the active skeletal muscle and the influence of exercise-induced dehydration level upon selected circulatory biomarkers of oxidative stress in exercising heat-stressed humans have not been systematically investigated.…”
Section: Introductionmentioning
confidence: 98%
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“…Furthermore, increasing levels of isoprostanes has been considered as a sensitive marker of lipid peroxidation as it is a product of the free radical-oxidation of phospholipids and therefore reflects the extent of oxidative stress induced lipid peroxidation (Nieman et al 2002;Nikolaidis et al 2011). We have recently shown that heat stress, independent of dehydration, induces a disruption of the redox balance as well as a decrease in SOD activity in resting and exercising humans (Laitano et al 2010). However, the contribution of the active skeletal muscle and the influence of exercise-induced dehydration level upon selected circulatory biomarkers of oxidative stress in exercising heat-stressed humans have not been systematically investigated.…”
Section: Introductionmentioning
confidence: 98%
“…To date, GSH exchange across the human leg has only been measured in plasma from exercising euhydrated subjects in two studies (Sahlin et al 1991;Hellsten et al 2001) and the potential effect of dehydration remains unknown. The mechanisms by which dehydration could alter the GSH exchange remains unclear, although it may involve increased ischemia-reperfusion stimulus due to changes in active muscle blood flow and increased oxidation to GSSG, as dehydration leads to increased body temperatures and it has been shown to lower antioxidant defense and increase GSSG concentration (Laitano et al 2010). As the greatest concentration of GSH in blood is found within the erythrocytes (Gohil et al 1988), the measurement of whole blood GSH and GSSG may be more appropriate to report the exchange of these markers across the human leg than changes in just blood plasma.…”
Section: Introductionmentioning
confidence: 99%
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“…However, this study did not examine the effects of antioxidant status or the effect of rehydration on F 2 -isoprostanes. Interestingly, Laitano et al (Laitano et al 2010) found that in euhydrated humans heat stress or exercise alone did not alter GSH, SOD activity, or increase plasma isoprostanes. However, combined heat stress and exercise increased both GSH and GSSG, decreased SOD activity, but did not alter isoprostanes.…”
Section: Introductionmentioning
confidence: 99%
“…This suggests that heat stress, independently of dehydration, increases antioxidant defense which may compensate for the effects of heat stress-induced oxidative stress. (Laitano et al 2010) .…”
Section: Introductionmentioning
confidence: 99%