Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

Yin, Yue; Su, Wen; Zhang, Jie; Huang, Wenping; Li, Xiaoyang; Ma, Hui; Tan, Mixiao; Song, Haohao; Cao, Guoliang; Yu, Shichong; Yu, Di; Jeong, Ji Hoon; Zhao, Xiao; Li, Hui; Nie, Guangjun; Wang, Hai

doi:10.1021/acsnano.1c03252

Cited by 83 publications

(87 citation statements)

References 44 publications

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“…In addition, they can be equipped with features such as the ability to encapsulate fragile structures such as DNA, mRNA, protein subunits, and the ability to release these agents over time and then self-degrade thanks to site-specific-adjusted biodegradation. 77 , 163 − 165 …”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Kiremitler

Kemerli

Kayacı

et al. 2022

ACS Appl. Nano Mater.

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Scientists, doctors, engineers, and even entire societies have become aware of the seriousness of the COVID-19 infection and are taking action quickly, using all the tools from protection to treatment against coronavirus SARS-CoV-2. Especially in this sense, scientific approaches and materials using nanotechnology are frequently preferred. In this review, we focus on how nanoscience and nanotechnology approaches can be used for protective equipment, diagnostic and treatment methods, medicine, and vaccine applications to stop the coronavirus SARS-CoV-2 and prevent its spread. SARS-CoV-2, which itself can be considered as a core–shell nanoparticle, can interact with various materials around it and remain bound for variable periods of time while maintaining its bioactivity. These applications are especially critical for the controlled use of disinfection systems. One of the most important processes in the fight against coronavirus is the rapid diagnosis of the virus in humans and the initiation of isolation and treatment processes. The development of nanotechnology-based test and diagnostic kits is another important research thrust. Nanotechnological therapeutics based on antiviral drug design and nanoarchitecture vaccines have been vital. Nanotechnology plays critical roles in the production of protective film surfaces for self-cleaning and antiviral masks, gloves, and laboratory clothes. An overview of literature studies highlighting nanotechnology and nanomaterial-based approaches to combat SARS-CoV-2 is presented.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Kiremitler

Kemerli

Kayacı

et al. 2022

ACS Appl. Nano Mater.

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show abstract

“…This makes them relevant for deployment in regions where cold storage facilities are scarce, a logistics hurdle for currently approved COVID-19 vaccines (Menon et al ., 2021 ). Initial reports of MNA-based vaccines assembled for delivery of DNA encoding the SARS-CoV-2 spike protein alongside adjuvant indicate that vaccine patches can be stored at room temperature for at least 30 days without sacrificing T cell responses (Yin et al ., 2021 ).…”

Section: Microneedle Arrays Provide An Accessible and Highly Modular Platform For Vaccination Against Current And Emerging Infectious Dismentioning

confidence: 99%

The Nanoparticle-Enabled Success of COVID-19 mRNA Vaccines and the Promise of Microneedle Platforms for Pandemic Vaccine Response

Kapnick

2022

DNA and Cell Biology

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The coronavirus disease 2019 (COVID-19) public health crisis has reached critical mass, but interdisciplinary research efforts have provided the global community with the first effective medical intervention to fight the pandemic—COVID-19 vaccines. Two of the vaccines approved for use in the United States and Europe deliver nucleic acid in the form of mRNA, the success of which would not be possible without biomaterials. Lipid nanoparticle (LNP)-based mRNA vaccines, discussed in this perspective, protect nucleic acids from degradation and deliver cargo directly to the intracellular compartment of cells where it is translated into the antigenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein that triggers protective immune responses. Despite success of LNP-based mRNA vaccines thus far, the pandemic has highlighted the need for emerging technologies that enable rapid development and increased accessibility to vaccination. Microneedle arrays, also discussed in this study, provide features that could lower barriers to vaccine access in resource-poor regions. The ability to exchange antigens within arrays could also facilitate swift vaccine deployment as public health needs evolve (e.g., in response to SARS-CoV-2 variants or entirely new pathogens). Therefore, the COVID-19 pandemic has spotlighted the readiness and value of biomaterials for the prevention and management of disease outbreaks.

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“…Ex vivo imaging of lymph node collected form sacrificed mice confirmed DNA vaccine migration to the lymph nodes. In vivo cellular immune responses showed that IFN-γ + CD4/8 + and IL-2 + CD4/8 + T cells or virus-specific IgG were significantly increased after vaccination ( 89 ).…”

Section: Efficacy Of Microneedle-based Vaccines In Preclinical and Cl...mentioning

confidence: 99%

“…From literature, MNs have been used to deliver different types of vaccines, including whole inactivated virus, subunit, DNA plasmid, recombinant protein, and antigen ( 89 , 95 , 109 ). However, ideal vaccine for MN delivery should be thermostable and maintain its antigenicity during manufacturing and sterilization processes ( 73 ).…”

Section: Vaccine Characteristics and Limitations Of Mns In Vaccine De...mentioning

confidence: 99%

Microneedle-Based Vaccine Delivery: Review of an Emerging Technology

et al. 2022

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Vaccination has produced a great improvement to the global health by decreasing/eradicating many infectious diseases responsible for significant morbidity and mortality. Thanks to vaccines, many infections affecting childhood have been greatly decreased or even eradicated (smallpox, measles, and polio). That is why great efforts are made to achieve mass vaccination against COVID-19. However, developed vaccines face many challenges with regard to their safety and stability. Moreover, needle phobia could prevent a significant proportion of the population from receiving vaccines. In this context, microneedles (MNs) could potentially present a solution to address these challenges. MNs represent single dose administration systems that do not need reconstitution or cold-chain storage. Being self-administered, pain-free, and capable of producing superior immunogenicity makes them a more attractive alternative. This review explores microneedles’ types, safety, and efficacy in vaccine delivery. Preclinical and clinical studies for microneedle-based vaccines are discussed and patent examples are included. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1208/s12249-022-02250-8.

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Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

Cited by 83 publications

References 44 publications

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

The Nanoparticle-Enabled Success of COVID-19 mRNA Vaccines and the Promise of Microneedle Platforms for Pandemic Vaccine Response

Microneedle-Based Vaccine Delivery: Review of an Emerging Technology

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