Seoul Virus Infection in a Wisconsin Patient with Recent Travel to China, March 2009: First Documented Case in the Midwestern United States

Nielsen, Carrie F.; Sethi, Vishal; Petroll, Andrew E.; Kazmierczak, James J.; Erickson, Bobbie R.; Nichol, Stuart T.; Rollin, Pierre E.; Davis, Jeffrey P.

doi:10.4269/ajtmh.2010.10-0424

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…This finding may suggest that previous hantavirus cases from Indonesia and other Southeast Asia countries with similar clinical presentations (elevated liver enzymes, lymphopenia, thrombocytopenia with/out hemorrhagic manifestations and renal syndromes) were SEOV infections. Consistent with previous reports, both our patients had elevated liver enzyme and thrombocytopenia [ 2 , 6 , 9 , 10 , 19 ] . Clinical misdiagnoses occurred with the two reported patients due to the non-specific signs and symptoms of SEOV infection.…”

Section: Discussionsupporting

confidence: 93%

“…Seoul virus (SEOV) is a member of hantavirus family that is carried by the rodent vectors Rattus rattus and Rattus norvegicus [ 1 ]. Both rodents are widespread globally, thus making SEOV distribution worldwide [ 1 ] with confirmed human cases in Asia [ 2 – 5 ], Europe [ 6 – 8 ], and North America [ 9 , 10 ]. The symptoms and signs of SEOV infection are not specific, including fever, headache, nausea, joint pain, cough, and a mild to moderate form of hemorrhagic fever with renal syndrome (HFRS) accompanied with elevation of liver enzyme [ 5 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Case report: two confirmed cases of human Seoul virus infections in Indonesia

et al. 2018

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BackgroundSeoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test antibodies seroconversion and RNA detection are not available in resource-limited setting like Indonesia.Case presentationWe report two confirmed cases of SEOV infection from Indonesia. Here, we illustrate the clinical presentations, hematology and biochemistry profiles, and outcomes of the two cases. Phylogenetic analysis revealed that SEOV sequences have highest homology to isolates obtained from rodents in Indonesia.ConclusionsThis report highlights the importance of considering SEOV infection in febrile patients with lymphopenia, thrombocytopenia, and elevation of liver enzyme despite the absence of hemorrhagic manifestations and renal syndromes. The public health importance of rodent-borne diseases such as SEOV infection urges an integrated epidemiological surveillance both in humans and rodents in Indonesia.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3482-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Case report: two confirmed cases of human Seoul virus infections in Indonesia

et al. 2018

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“…Seoul virus is a rodent-borne hantavirus, which has been associated with hemorrhagic fever with renal syndrome, * and has a mortality rate of approximately 1–2% ( 1 ). It is transmitted by the brown Norway rat ( Rattus norvegicus ), which is found worldwide ( 2 , 3 ). As of January 2017, 17 laboratory-confirmed acute human cases of Seoul virus infection associated with pet rat contact have been identified in the United States as part of this outbreak investigation ( 4 ).…”

mentioning

confidence: 99%

Notes from the Field: Multiple Cases of Seoul Virus Infection in a Household with Infected Pet Rats — Tennessee, December 2016–April 2017

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Mullins²,

May³

et al. 2017

MMWR Morb. Mortal. Wkly. Rep.

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“…Involvement of the liver has mostly been reported in SEOV cases (Kim et al, 1995 ; Zhang et al, 2011 ), where it results in acute viral hepatitis-like manifestations with lobular necrosis without viral inclusions, atypical cells, vasculitis, or fibrosis, a painful enlarged liver and distinct elevation of liver enzymes (Kim et al, 1995 ; Nielsen et al, 2010 ; Swanink et al, 2018 ). In addition, focal midzonal necrosis associated with mild mononuclear infiltrates can be observed in the liver during HTNV infection (Elisaf et al, 1993 ).…”

Section: Hfrs/ne In Humans and Disease Modelsmentioning

confidence: 99%

Orthohantavirus Pathogenesis and Cell Tropism

Noack

Goeijenbier

Reusken

et al. 2020

Front. Cell. Infect. Microbiol.

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Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs. Orthohantavirus infection in humans can result in two distinct clinical outcomes: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). While both syndromes develop following respiratory transmission and are associated with multi-organ failure and high mortality rates, little is known about the mechanisms that result in these distinct clinical outcomes. Therefore, it is important to identify which cell types and tissues play a role in the differential development of pathogenesis in humans. Here, we review current knowledge on cell tropism and its role in pathogenesis during orthohantavirus infection in humans and reservoir rodents. Orthohantaviruses predominantly infect microvascular endothelial cells (ECs) of a variety of organs (lungs, heart, kidney, liver, and spleen) in humans. However, in this review we demonstrate that other cell types (e.g., macrophages, dendritic cells, and tubular epithelium) are infected as well and may play a role in the early steps in pathogenesis. A key driver for pathogenesis is increased vascular permeability, which can be direct effect of viral infection in ECs or result of an imbalanced immune response in an attempt to clear the virus. Future studies should focus on the role of identifying how infection of organ-specific endothelial cells as well as other cell types contribute to pathogenesis.

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Seoul Virus Infection in a Wisconsin Patient with Recent Travel to China, March 2009: First Documented Case in the Midwestern United States

Cited by 10 publications

References 14 publications

Case report: two confirmed cases of human Seoul virus infections in Indonesia

Case report: two confirmed cases of human Seoul virus infections in Indonesia

Notes from the Field: Multiple Cases of Seoul Virus Infection in a Household with Infected Pet Rats — Tennessee, December 2016–April 2017

Orthohantavirus Pathogenesis and Cell Tropism

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