Sensory Trick in a Patient with Cervical Dystonia: Insights from Magnetoencephalography

Mahajan, Abhimanyu; Zillgitt, Andrew; Bowyer, Susan M.; Sidiropoulos, Christos

doi:10.3390/brainsci8040051

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…Magnetoencephalography coherence source imaging (MEG-CSI) has also been used to investigate CD [ 9 , 10 ]. Our previous MEG-CSI study demonstrated difference in resting-state coherence between controls and CD patients in the fronto-striatal region, but not in occipito-striatal, parieto-striatal and striato-temporal networks [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study

et al. 2018

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Background: Cervical dystonia (CD) patients have impaired working memory, processing speed and visual-motor integration ability. We used magnetoencephalography (MEG) to investigate changes in cerebral oscillations in CD patients during an executive function test, before and after administration of botulinum toxin. Methods: MEG data were collected from five CD patients while they performed a visual continuous performance task (CPT), before and after they received a botulinum toxin injection. MEG data was also collected on five controls matched for age and gender. Coherence source imaging was performed to quantify network connectivity of subjects. Results: Controls demonstrated two errors with visual CPT; CD patients demonstrated six and three errors pre- and post-botulinum toxin respectively. After botulinum toxin, mean time from cue to correct response was 0.337 s in controls, 0.390 s in patients before botulinum toxin injection, and 0.366 s after the injection. Differences in coherence between controls and patients were found in the following brain regions: Fronto-frontal, fronto-parietal, fronto-striatal, fronto-occipital, parieto-parietal and temporo-parietal. Intrahemispheric and interhemispheric networks were affected. Post injection, there was minimal change in coherence in the above-mentioned networks. Discussion: Neuropsychological testing suggests difference in coherence in frontal circuits between CD cases and controls during the visual CPT, which may reflect subjects’ increased difficulty with the task. Botulinum toxin is associated with minimal improvement with executive function in CD.

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Section: Introductionmentioning

confidence: 99%

Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study

et al. 2018

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“…10 This is further supported by a recent case study demonstrating an association between the effect of sensory trick and physiological characteristics of the parietal cortex, which is known for its role in sensorimotor integration. 11 Perhaps gradually decreasing plasticity in the sensorimotor mappings, in a manner specific to CD pathology and not just age-related, makes the sensory trick less effective over time.…”

Section: Discussionmentioning

confidence: 99%

Sensory Tricks Are Associated with Higher Sleep-Related Quality of Life in Cervical Dystonia

Benadof

Cisneros

Appelbaum

et al. 2019

Tremor and Other Hyperkinetic Movements

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Background: Sensory tricks are compensatory gestures that cervical dystonia (CD) patients use to reduce abnormal neck posture and movements. Although sensory tricks are common in CD, little is known about whether trick efficacy changes over time or has effect on quality of life. Methods: We analyzed clinical data and video recordings from 188 patients with isolated CD. We calculated the duration of CD and assessed the Toronto Western Spasmodic Torticollis Rating Scales and the Cervical Dystonia Impact Profile (CDIP-58). Results: A longer duration of CD corresponded to a less effective sensory trick (r(187) = 0.1901, p = 0.009). Patients who demonstrated more effective sensory tricks reported higher sleep-related quality of life than patients with less effective sensory tricks (r(187) = 0.1680, p = 0.0212). There were no significant relationships between the effectiveness of a sensory trick and the other aspects of quality of life as measured by the CDIP-58. Discussion: Patients who have had CD longer had less effective sensory tricks consistent with patients' verbal reports of previously having a trick that no longer works. Patients should be apprised of a wide variety of sensory tricks because their previous tricks may lose efficacy over time and because more effective tricks are associated with higher sleep-related quality of life.

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“…A detailed description of the following MEG-based MEG-CSI methodology and data processing used in this study has been previously published by our lab. 10,11…”

Section: Methodsmentioning

confidence: 99%

“…9 Our lab has also previously published work on cervical dystonia using MEG-CSI. 10,11 In the present study, we characterized the functional connectivity in a patient with ED where touch is used to evoke dystonic movements.…”

Section: Introductionmentioning

confidence: 99%

Sensorimotor Integration and GABA-ergic Activity in Embouchure Dystonia: An Assessment with Magnetoencephalography

Bulica

Sidiropoulos

Mahajan

et al. 2019

Tremor and Other Hyperkinetic Movements

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BackgroundEmbouchure dystonia (ED) is a task-specific dystonia affecting musicians thought to be related to alteration in sensorimotor processing and loss of cortical inhibition.Case ReportMagnetoencephalography-coherence source imaging (MEG-CSI) was used to map connectivity between brain regions by imaging neuronal oscillations that are coherent across the brain in patient with ED at rest and while using the index finger to evoke dystonia normally triggered by playing the flute.DiscussionDuring rest, there was increased coherence in the bilateral frontal and parietal regions that became more focal during dystonia. Diffuse hyperexcitability and increased coherence persisted in bilateral parietal regions as well as the bilateral frontal regions.

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Sensory Trick in a Patient with Cervical Dystonia: Insights from Magnetoencephalography

Cited by 13 publications

References 19 publications

Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study

Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study

Sensory Tricks Are Associated with Higher Sleep-Related Quality of Life in Cervical Dystonia

Sensorimotor Integration and GABA-ergic Activity in Embouchure Dystonia: An Assessment with Magnetoencephalography

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