Sensorineural Hearing Loss in Children After Liver Transplantation

Abstract

Children receiving liver transplants are at an increased risk for SNHL. Those with the short-bowel syndrome have the greatest prevalence of SNHL. Among the subset of children with biliary atresia receiving liver transplants before 2 years of age, statistical analysis demonstrates a dose-response relationship between the receipt of amikacin and the occurrence of SNHL.

Risk of hearing impairment in pediatric liver transplant recipients: A single center study

“…Our findings are consistent with those previously reported in a retrospective review of 125 pediatric liver transplant recipients (7). In that report, formal audiology evaluations were available for only 50% of the patient population.…”

Neurologic complications of liver transplantation in adults

“…This has not been reported previously in adult liver transplantation. Deafness has occurred in pediatric patients undergoing liver transplantation 41 and has previously been reported in association with both tacrolimus and cyclosporine, 42,43 although both cases were in renal transplant recipients. With our retrospective study design, it is difficult to know why these patients developed this complication.…”

Aminoglycoside- and glycopeptide-induced ototoxicity in children: a systematic review

“…Cross-sectional aetiology studies were performed in healthy children 57 and children with hearing loss. 55 , 56 Amikacin, 32 , 35 , 42–46 , 48 , 50 , 53 gentamicin, 28–30 , 34–36 , 41–43 , 48 , 50 , 52 , 55 , 56 streptomycin 39 , 46 , 51 , 57 and tobramycin 31 , 33 , 35 , 41–43 , 50 were the most frequently administered aminoglycosides, whereas vancomycin was the only administered glycopeptide antibiotic ( Figure 3 ). 38 , 41 Treatment dosages ranged between 4.5–8.0 mg/kg/day for gentamicin, 15–22.5 mg/kg/day for amikacin, 9.3–10.0 mg/kg/day for tobramycin, 8.0 mg/kg/day for netilmicin and 15 mg/kg/day for streptomycin.…”

“…In patients who suffered from chronic renal failure 47 and in those who had received a liver transplant, diuretics were concomitantly applied with aminoglycosides. 42 The frequency of hearing loss ranged from 12% to 38%. Other co-medication reported within studies included antibiotics such as cephalosporins, 30 , 33 , 38 , 45 , 52 macrolides, 30 , 31 penicillins, 28 , 34 , 45 , 55 sulphonamides and trimethoprim, 30 , 45 antiprotozoics, 45 antifungals, 52 inhaled or topical aminoglycosides, 40 , 48 antimalarials 55 and tuberculostatic agents ( Tables S3–S5 ).…”