Sensorineural Hearing Loss after Treatment for Head and Neck Cancer: A Review of the Literature

Shorter, Phoebe; Harden, Fiona; Owen, Robert; Burmeister, Bryan; Foote, Matthew

doi:10.1016/j.jmir.2013.11.003

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…27,28 Data are limited on the association of chemotherapy with long-term patientreported toxic reactions, 29 although large prospective randomized studies have not demonstrated a significant worsening of physician-assessed late toxicities. 27,28 Other studies have tied sensorineural hearing loss in patients with head and neck cancer with cochlear radiation dose and cisplatin use, [30][31][32][33][34] while an older, single-institution study found that concurrent chemotherapy increased late physician-assessed pharyngeal, laryngeal, and oral cavity-related toxic effects. 35 Owing to the paucity of data, many risk-benefit discussions have historically focused on the more acute complications of concurrent therapy.…”

Section: Discussionmentioning

confidence: 99%

Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer

Dohopolski

Diao

Hutcheson

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceOncologic outcomes are similar for patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with primary surgery or radiotherapy. However, comparative differences in long-term patient-reported outcomes (PROs) between modalities are less well established.ObjectiveTo determine the association between primary surgery or radiotherapy and long-term PROs.Design, Setting, and ParticipantsThis cross-sectional study used the Texas Cancer Registry to identify survivors of OPSCC treated definitively with primary radiotherapy or surgery between January 1, 2006, and December 31, 2016. Patients were surveyed in October 2020 and April 2021.ExposuresPrimary radiotherapy and surgery for OPSCC.Main Outcomes and MeasuresPatients completed a questionnaire that included demographic and treatment information, the MD Anderson Symptom Inventory–Head and Neck (MDASI-HN) module, the Neck Dissection Impairment Index (NDII), and the Effectiveness of Auditory Rehabilitation (EAR) scale. Multivariable linear regression models were performed to evaluate the association of treatment (surgery vs radiotherapy) with PROs while controlling for additional variables.ResultsQuestionnaires were mailed to 1600 survivors of OPSCC identified from the Texas Cancer Registry, with 400 responding (25% response rate), of whom 183 (46.2%) were 8 to 15 years from their initial diagnosis. The final analysis included 396 patients (aged ≤57 years, 190 [48.0%]; aged &gt;57 years, 206 [52.0%]; female, 72 [18.2%]; male, 324 [81.8%]). After multivariable adjustment, no significant differences were found between surgery and radiotherapy outcomes as measured by the MDASI-HN (β, −0.1; 95% CI, −0.7 to 0.6), NDII (β, −1.7; 95% CI, −6.7 to 3.4), and EAR (β, −0.9; 95% CI −7.7 to 5.8). In contrast, less education, lower household income, and feeding tube use were associated with significantly worse MDASI-HN, NDII, and EAR scores, while concurrent chemotherapy with radiotherapy was associated with worse MDASI-HN and EAR scores.Conclusions and RelevanceThis population-based cohort study found no associations between long-term PROs and primary radiotherapy or surgery for OPSCC. Lower socioeconomic status, feeding tube use, and concurrent chemotherapy were associated with worse long-term PROs. Further efforts should focus on the mechanism, prevention, and rehabilitation of these long-term treatment toxicities. The long-term outcomes of concurrent chemotherapy should be validated and may inform treatment decision making.

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Section: Discussionmentioning

confidence: 99%

Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer

Dohopolski

Diao

Hutcheson

et al. 2023

JAMA Otolaryngol Head Neck Surg

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“… 5 , 6 This treatment is highly effective, but both radiotherapy and cisplatin‐based CRT in head and neck cancer (HNC) patients can contribute to hearing loss and ototoxicity. 7 Ototoxicity refers to auditory system dysfunction inclusive of cochlear disorders such as hearing loss and tinnitus; vestibular disorders such as imbalance, vertigo, and dizziness; and neural injury, among others. 8 Hearing loss can contribute to a constellation of functional deficits in daily life activities, including communication problems with impaired speech perception, mental health problems, psychosocial impairment, cognitive problems such as dementia, low self‐esteem, diminished physical function, and problems with work and employment.…”

Section: Introductionmentioning

confidence: 99%

“… 14 However, delayed radiotherapy‐associated injury of the inner ear, including the cochlea and the acoustic nerve, results in permanent sensorineural hearing loss (SNHL). 14 Platinum‐based chemotherapy can also contribute to injury to the cochlea or retro‐cochlear region including the vestibulocochlear nerve, and other components of the central auditory system, 7 , 14 , 15 resulting in bilateral, progressive, permanent, and high‐frequency SNHL. 14 Theunissen et al, in a comprehensive review of 21 studies in HNC patients, reported an incidence of SNHL of 0% to 43% immediately following radiotherapy and 17% to 88% in immediately following CRT.…”

Section: Introductionmentioning

confidence: 99%

“…Concurrent chemoradiation (CRT) with high‐dose cisplatin is commonly the treatment of choice 5,6 . This treatment is highly effective, but both radiotherapy and cisplatin‐based CRT in head and neck cancer (HNC) patients can contribute to hearing loss and ototoxicity 7 . Ototoxicity refers to auditory system dysfunction inclusive of cochlear disorders such as hearing loss and tinnitus; vestibular disorders such as imbalance, vertigo, and dizziness; and neural injury, among others 8 .…”

Section: Introductionmentioning

confidence: 99%

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Association of hearing loss and tinnitus symptoms with health‐related quality of life among long‐term oropharyngeal cancer survivors

et al. 2022

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Background This study investigated the association of hearing loss and tinnitus with overall health‐related quality of life (HRQoL) among long‐term oropharyngeal cancer (OPC) survivors. Methods This study included OPC survivors treated between 2000 and 2013 and surveyed from September 2015 to July 2016. Hearing loss and tinnitus were measured by asking survivors to rate their “difficulty with hearing loss and/or ringing in the ears” from 0 (not present) to 10 (as bad as you can imagine). Hearing loss and tinnitus scores were categorized as follows: 0 for none, 1–4 for mild, and 5–10 for moderate to severe. The primary outcome was the mean score of MD nderson Symptom Inventory Head & Neck module interference component as a HRQoL surrogate dichotomized as follows: 0 to 4 for none to mild and 5 to 10 for moderate to severe interference. Results Among 880 OPC survivors, 35.6% (314), reported none, 39.3% (347) reported mild, and 25.1% (221) reported moderate to severe hearing loss and tinnitus. On multivariable analysis, mild (OR, 5.83; 95% CI; 1.48–22.88; p = 0.012) and moderate (OR, 30.01; 95% CI; 7.96–113.10; p < 0.001) hearing loss and tinnitus were associated with higher odds of reporting moderate to severe symptom interference scores in comparison to no hearing loss and tinnitus. This association of hearing dysfunction was consistent with all domains of HRQoL. Conclusions Our findings provide preliminary evidence to support the need for continued audiological evaluations and surveillance to detect hearing dysfunction, to allow for early management and to alleviate the long‐term impact on QoL.

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Effect of cisplatin chemotherapy on the inner ear function and serum prestin concentration

Jalali

Saedi

Saadat

2021

Eur Arch Otorhinolaryngol

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Sensorineural Hearing Loss after Treatment for Head and Neck Cancer: A Review of the Literature

Cited by 5 publications

References 48 publications

Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer

Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer

Association of hearing loss and tinnitus symptoms with health‐related quality of life among long‐term oropharyngeal cancer survivors

Effect of cisplatin chemotherapy on the inner ear function and serum prestin concentration

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