Sensorimotor performance in euthymic bipolar disorder: the MPraxis (PennCNP) analysis

Neves, Maila de Castro Lourenço das; Albuquerque, Maicon Rodrigues; Neves, Fernando Silva; Lage, Guilherme Menezes; Malloy-Diniz, Leandro Fernandes; Nicolato, Rodrigo; Corrêa, Humberto

doi:10.1590/1516-4446-2013-1243

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Participants were instructed to click on squares that appear randomly on the screen, with each successive square smaller and thus more difficult to track. The test depends upon function of visual and sensorimotor cortices ( Gur et al, 2001 ; Gur et al, 2010 ; Neves et al, 2014 ).…”

Section: Methodsmentioning

confidence: 99%

Recovery of consciousness and cognition after general anesthesia in humans

Mashour

Palanca

Basner

et al. 2021

eLife

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Understanding how the brain recovers from unconsciousness can inform neurobiological theories of consciousness and guide clinical investigation. To address this question, we conducted a multicenter study of 60 healthy humans, half of whom received general anesthesia for three hours and half of whom served as awake controls. We administered a battery of neurocognitive tests and recorded electroencephalography to assess cortical dynamics. We hypothesized that recovery of consciousness and cognition is an extended process, with differential recovery of cognitive functions that would commence with return of responsiveness and end with return of executive function, mediated by prefrontal cortex. We found that, just prior to the recovery of consciousness, frontal-parietal dynamics returned to baseline. Consistent with our hypothesis, cognitive reconstitution after anesthesia evolved over time. Contrary to our hypothesis, executive function returned first. Early engagement of prefrontal cortex in recovery of consciousness and cognition is consistent with global neuronal workspace theory.

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Section: Methodsmentioning

confidence: 99%

Recovery of consciousness and cognition after general anesthesia in humans

Mashour

Palanca

Basner

et al. 2021

eLife

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“…The current implementation uses 20 consecutive stimuli. As a screener for computer skill, the MP has been included in every implementation of the CNB and validated for sensitivity to age effects (18), sex-differences (40), and associations with psychopathology (33). …”

Section: Methodsmentioning

confidence: 99%

Development and Validation of the Cognition Test Battery for Spaceflight

Basner

Savitt²,

Moore³

et al. 2015

aerosp med hum perform

119

131

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Background Sustained high-level cognitive performance is of paramount importance for the success of space missions, which involve environmental, physiological and psychological stressors that may affect brain functions. Despite subjective symptom reports of cognitive fluctuations in spaceflight, the nature of neurobehavioral functioning in space has not been clarified. Methods We developed a computerized cognitive test battery (Cognition) that has sensitivity to multiple cognitive domains and was specifically designed for the high-performing astronaut population. Cognition consists of 15 unique forms of 10 neuropsychological tests that cover a range of cognitive domains including emotion processing, spatial orientation, and risk decision making. Cognition is based on tests known to engage specific brain regions as evidenced by functional neuroimaging. Here we describe the first normative and acute total sleep deprivation data on the Cognition test battery as well as several efforts underway to establish the validity, sensitivity, feasibility, and acceptability of Cognition. Results Practice effects and test-retest variability differed substantially between the 10 Cognition tests, illustrating the importance of normative data that both reflect practice effects and differences in stimulus set difficulty in the population of interest. After one night without sleep, medium to large effect sizes were observed for 3 of the 10 tests addressing vigilant attention (Cohen’s d=1.00), cognitive throughput (d=0.68), and abstract reasoning (d=0.65). Conclusions In addition to providing neuroimaging-based novel information on the effects of spaceflight on a range of cognitive functions, Cognition will facilitate comparing the effects of ground-based analogs to spaceflight, increase consistency across projects, and thus enable meta-analyses.

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“…In addition to mood changes, patients with BD tend to show deficits in executive functions, verbal and visuospatial episodic memory, working memory (WM), verbal learning, information processing speed, sustained attention, and sensorimotor performance (Bora et al, 2009; Latalova et al, 2011; Lage et al, 2013; Loschiavo et al, 2013; Lee et al, 2014; Neves et al, 2014). Some studies have suggested more severe cognitive deficits in episodes of manic/mixed mood compared with depressive and euthymic episodes (Sweeney et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Disentangling Working Memory Functioning in Mood States of Bipolar Disorder: A Systematic Review

et al. 2017

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Working memory (WM) deficits are often reported in patients with Bipolar Disorder (BD). However, it is not clear about the nature of these WM deficits (update or serial order processes) and their association with each BD states (euthymic, mania, and depressive). This review investigated the association between BD patient's states and the functioning of WM components. For this purpose, we carried out a systematic review fulfilling a search in the databases Medline, Scopus, SciELO, and Web of Science using specific terms in the abstracts of the articles that generated 212 outcomes in the restricted period from 2005 to 2016. Twenty-three papers were selected, completely read, and analyzed using PICOS strategy. The mood episodes predicted deficits in different components of WM in BD patients (the phonological loop or visuospatial sketchpad) and were associated with different WM processes (updating and serial recall). Lower cognitive scores persist even in remission of symptoms. This result suggests that WM deficit apparently is stage-independent in BD patients. Furthermore, findings suggest that the neutral point on Hedonic Detector component of WM could be maladjusted by BD.

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Sensorimotor performance in euthymic bipolar disorder: the MPraxis (PennCNP) analysis

Cited by 8 publications

References 15 publications

Recovery of consciousness and cognition after general anesthesia in humans

Recovery of consciousness and cognition after general anesthesia in humans

Development and Validation of the Cognition Test Battery for Spaceflight

Disentangling Working Memory Functioning in Mood States of Bipolar Disorder: A Systematic Review

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