Biochemical Pharmacology volume 78, issue 6, P573-582 2009 DOI: 10.1016/j.bcp.2009.05.016 View full text
Mi-Ju Kim, Hak-Bong Kim, Jae-Ho Bae, Jae-Won Lee, Soo-Jung Park, Dong-Wan Kim, Sang-Ick Park, Chi-Dug Kang, Sun-Hee Kim

Abstract: Despite the fact that many cancer cells are sensitive to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, human K562 leukemic cells showed resistance to TRAIL-induced apoptosis. Interestingly, K562/R3 cells, a stable TRAIL-sensitive variant isolated from K562 cells, showed down-regulation of DNA-PK/Akt pathway and a high responsiveness to TRAIL-mediated growth inhibition and apoptosis. We revealed that siRNA-mediated suppression of DNA-PKcs led to decreased phosphorylation of Akt and Bad, a tar…

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