Sensitization and Desensitization in Man With Snake Venom (Ancistrodon Piscivorus)

Peck, Samuel M.

doi:10.1001/archderm.1933.01450040317013

Cited by 7 publications

(1 citation statement)

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“…Anaphylaxis and immediate-type respiratory reactions to snake venom have been reported previously (Parrish, Watt & Arnold, 1957;Ellis & Smith, 1965;Mendes, 1960;Stanic, 1956;Parrish, 1957). Skin testing with snake venom to demonstrate specific reaginic antibody has been complicated by local haemorrhagic (Peck, 1933;Golan & Hill, 1940) and non-specific weal and erythema responses Parrish, 1957;Peck, 1933;Golan & Hill, 1940) in both normals and venom sensitive individuals, presumably caused by the enzymatic and toxic activity of these agents. The following is a case report of an IgE mediated response to snake venom.…”

Section: Introductionmentioning

confidence: 99%

Allergy to snake venom: the use of radioimmunoassay for the detection of IgE antibodies against antigens not suitable for cutaneous tests

Kelly

Patterson

1973

Clin Experimental Allergy

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Summary A case of a severe immediate‐type respiratory reaction to rattlesnake venom is reported. Reaginic antibody to the snake venom was demonstrated in the patient's serum by long latency passive cutaneous anaphylaxis in a monkey. IgE antibody against the venom was demonstrated in the patient's serum by a solid phase radioimmunoassay. This report confirms the immediate‐type respiratory reactions that have been observed by others. The study also confirms that these reactions are associated with reaginic antibodies against the venom and that these antibodies are probably of the IgE class. It thus appears most likely that this patient's reaction was due to IgE reaginic antibody. In vitro assays for specific IgE activity may be particularly valuable in cases where antigen may be toxic for skin testing.

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