J. Biochem. Mol. Toxicol.
 1998
DOI: 10.1002/(sici)1099-0461(1998)12:4<245::aid-jbt7>3.0.co;2-l
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Sensitivity of bovine retinal acetylcholinesterase (E.C. 3.1.1.7) toward tacrine: Kinetic characterization

Abdulaziz A. Al‐Jafari
1
,
Mohammad Amjad Kamal
2
,
Abdullah S. Alhomida
3
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Cited by 12 publications

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“…Having shown that the DIOS‐TOFMS method is quantitative, a series of experiments was performed to characterize the enzyme kinetics for acetylcholine esterase and the inhibitor tacrine. Using DIOS‐TOFMS, the Michaelis constant for acetylcholine esterase was found to be 98 μM, in good agreement with reported values 21,22. The 50% inhibition constant, or IC 50 , for tacrine was found to be 32.0 nM by DIOS‐TOFMS and 31.8 nM by LC/MS/MS.…”
Section: Discussionsupporting
confidence: 85%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Having shown that the DIOS‐TOFMS method is quantitative, a series of experiments was performed to characterize the enzyme kinetics for acetylcholine esterase and the inhibitor tacrine. Using DIOS‐TOFMS, the Michaelis constant for acetylcholine esterase was found to be 98 μM, in good agreement with reported values 21,22. The 50% inhibition constant, or IC 50 , for tacrine was found to be 32.0 nM by DIOS‐TOFMS and 31.8 nM by LC/MS/MS.…”
Section: Discussionsupporting
confidence: 85%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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