Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment

Scheffold, Christian; Kapfhammer, Hans-Peter; Rothenhäusler, Hans-Bernd; Haller, M.; Briegel, Josef; Schmidt, Maren; Krauseneck, Till; Durst, K.; Schelling, Gustav

doi:10.1007/s001340050932

Cited by 241 publications

(206 citation statements)

References 29 publications

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“…To have more specific evaluation of PTSD symptoms, interested researchers should use a PTSD-specific instrument. Previous research has validated the IES-R and the Post-Traumatic Stress Syndrome 10-Questions Inventory (vs. semistructured diagnostic interviews) (33,42) and the UK-Post-Traumatic Stress Syndrome 14-Questions Inventory (vs. the Post-traumatic Stress Diagnostic Scale) (43) for PTSD in this population.…”

Section: Original Researchmentioning

confidence: 99%

The SF-36 Offers a Strong Measure of Mental Health Symptoms in Survivors of Acute Respiratory Failure. A Tri-National Analysis

et al. 2016

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Rationale: Survivors of acute respiratory failure commonly experience long-term psychological sequelae and impaired quality of life. For researchers interested in general mental health, using multiple condition-specific instruments may be unnecessary and inefficient when using the Medical Outcomes Study Short Form (SF)-36, a recommended outcome measure, may suffice. However, relationships between the SF-36 scores and commonly used measures of psychological symptoms in acute survivors of respiratory failure are unknown.Objectives: Our objective is to examine the relationship of the SF-36 mental health domain (MH) and mental health component summary (MCS) scores with symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) evaluated using validated psychological instruments.Methods: We conducted a cross-sectional analysis of 1,229 participants at 6-and 12-month follow-up assessment using data from five studies from the United States, the United Kingdom, and Australia.Measurements and Main Results: Symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), Depression Anxiety Stress Scales, the Davidson Trauma Scale, Impact of Event Scale (IES), and IES-Revised (IES-R). At 6-month assessment there were moderate to strong correlations of the SF-36 MH scores with HADS depression and anxiety symptoms (r = 20.74 and 20.79) and with IES-R PTSD symptoms (r = 20.60) in the pooled analyses. Using the normalized population mean of 50 on the SF-36 MH domain score as a cut-off, positive predictive values were 16 and 55% for substantial depression; 20 and 68% for substantial anxiety (Depression Anxiety Stress Scales and HADS, respectively); and 40, 44, and 67% for substantial PTSD symptoms (IES-R, IES, and Davidson Trauma Scale, respectively). Negative predictive values were high. The area under the receiver operating characteristics curve of the SF-36 MH score was high for depression, anxiety, and PTSD symptoms (0.88, 0.91, and 0.84, respectively). All results were consistent for the MCS, across the individual studies, and for the 12-month assessment.Conclusions: For researchers interested in general mental health status, the SF-36 MH or MCS offers a strong measure of psychological symptoms prevalent among survivors of acute respiratory failure. For researchers interested in specific conditions, validated psychological instruments should be considered.

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Section: Original Researchmentioning

confidence: 99%

The SF-36 Offers a Strong Measure of Mental Health Symptoms in Survivors of Acute Respiratory Failure. A Tri-National Analysis

et al. 2016

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“…This instrument records the presence and intensity of 10 common stress symptoms: (1) sleep distur- bance, (2) nightmares, (3) depression, (4) hyperalertness, (5) withdrawal (emotional numbing and inability to care for others), (6) generalized irritability, (7) frequent changes in mood, (8) guilt, (9) fear and avoidance reactions when reminded of hospitals and diseases and (10) increased muscle tension. Patients rate their symptoms, using a scale from 1 (never) to 7 (always) [29,30] .…”

Section: Quantification Of Pain and Stress Severity In Crps And Fm Pamentioning

confidence: 99%

Lymphocyte Subsets and the Role of Th1/Th2 Balance in Stressed Chronic Pain Patients

Kaufmann

Eisner

Richter

et al. 2007

Neuroimmunomodulation

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Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of lymphocyte subsets under stress and pain conditions is limited. Methods: We performed a comparative study in 15 patients with CRPS type I, 22 patients with FM and 37 age- and sex-matched healthy controls and investigated the influence of pain and stress on lymphocyte number, subpopulations and the Th1/Th2 cytokine ratio in T lymphocytes. Results: Lymphocyte numbers did not differ between groups. Quantitative analyses of lymphocyte subpopulations showed a significant reduction of cytotoxic CD8+ lymphocytes in both CRPS (p < 0.01) and FM (p < 0.05) patients as compared with healthy controls. Additionally, CRPS patients were characterized by a lower percentage of IL-2-producing T cell subpopulations reflecting a diminished Th1 response in contrast to no changes in the Th2 cytokine profile. Conclusions: Future studies are warranted to answer whether such immunological changes play a pathogenetic role in CRPS and FM or merely reflect the consequences of a pain-induced neurohumoral stress response, and whether they contribute to immunosuppression in stressed chronic pain patients.

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“…The German version of the PTSS-10 (range: 10-70 points) has been successfully validated in patients with PTSD after prolonged ICU treatment, and has proved to be a reliable scale (Crohnbach's alpha = 0.93). An optimal cut-off score of 35 points of the questionnaire for diagnosis of PTSD has been noted [38]. To evaluate the patients' perception of a range of socially supportive experiences, the Social Support Scale (SSS) [39] was used.…”

Section: Psychometric Testsmentioning

confidence: 99%

Psychiatric and Psychosocial Outcome of Orthotopic Liver Transplantation

Rothenhäusler¹,

Ehrentraut²,

Kapfhammer³

et al. 2002

Psychother Psychosom

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Background:The study aimed to explore the prevalence of psychiatric disorders among orthotopic liver transplantation (OLT) recipients, and to investigate how psychiatric morbidity was linked to health-related quality of life (HRQOL). Methods: We recruited 75 patients who had undergone OLT a median of 3.8 years previously (range = 5-129 months). Psychiatric morbidity was assessed using the Structural Clinical Interview for the DSM-III-R. Psychometric observer-rating and self-rating scales were administered to evaluate cognitive functioning (SKT), depressive symptomatology (HAMD 17 ), posttraumatic stress symptoms (PTSS-10), social support (SSS), and HRQOL (SF-36 Health Status Questionnaire). Treatment characteristics were obtained from medical records. Results: 22.7% (n = 17) of our sample had a current or probable psychiatric diagnosis according to DSM-III-R: 2.7% full posttraumatic stress disorder (PTSD) (n = 2), 2.7% major depressive disorder (MDD) comorbid to full PTSD (n = 2), 1.3% MDD comorbid to partial PTSD (n = 1), and 16% partial PTSD (n = 12). Patients with PTSD symptoms demonstrated lower cognitive performance, higher severity of depressive symptoms and more unfavorable perception of social support. OLT-related PTSD symptomatology was associated with maximal decrements in HRQOL. The duration of intensive care treatment, the number of medical complications, and the occurrence of acute rejection were positively correlated with the risk of PTSD symptoms subsequent to OLT. Conclusion: OLT-related PTSD symptomatology impairing HRQOL is a complication for a subgroup of OLT recipients. Health-care providers should be aware of the possible presence of PTSD in OLT survivors.

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Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment

Abstract: The questionnaire was found to be a responsive, valid and reliable instrument to screen survivors of intensive care for PTSD.

Cited by 241 publications

References 29 publications

The SF-36 Offers a Strong Measure of Mental Health Symptoms in Survivors of Acute Respiratory Failure. A Tri-National Analysis

The SF-36 Offers a Strong Measure of Mental Health Symptoms in Survivors of Acute Respiratory Failure. A Tri-National Analysis

Lymphocyte Subsets and the Role of Th1/Th2 Balance in Stressed Chronic Pain Patients

Psychiatric and Psychosocial Outcome of Orthotopic Liver Transplantation

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