Sensing Inside the Living Cells

Demchenko, Alexander P.

doi:10.1007/978-3-319-20780-3_13

Cited by 3 publications

(2 citation statements)

References 168 publications

(174 reference statements)

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“…Fluorescence is a highly sensitive technique and has been mostly applied for optical detection at the cellular level. Fiberoptic nanosensors also provide useful tools for remote insitu monitoring [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Among the optical techniques, fluorescence (e.g. visible (Vis) [2], near-infrared fluorescence (NIRF) [17][18][19], total internal reflection fluorescence (TIRF) [2,20] has been mostly applied. However, other useful optical properties of NPs include surface-enhanced Raman scattering (SERS) [21,22], surface plasmon resonance (SPR) [23], resonance light scattering (RLS) [24], two-photon absorption (TPA) [25].…”

Section: Introductionmentioning

confidence: 99%

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Optical Chemical Nanosensors in Clinical Applications

Turel

Mastnak

Lobnik

2013

DDF

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Because of their size and versatile chemistry, nanomaterials represent today powerful tools for (bio) sensing applications. Various types of nanomaterials have proven to be practical, not only for the determination of clinically relevant parameters, but also for diagnostics, drug delivery and treatment of diseases (e.g. cancer). In this short review, types of nanomaterials used in medical applications are briefly described along with some of their applications where the nanomaterials optical properties can be exploited. The question of the toxicity of nanomaterials and the issue of future trends are also raised.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optical Chemical Nanosensors in Clinical Applications

Turel

Mastnak

Lobnik

2013

DDF

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Monitoring the microenvironment inside polymeric micelles using the fluorescence probe 6-propionyl-2-dimethylaminonaphthalene (PRODAN)

Orellano

Chiapetta

Silber

et al. 2021

Journal of Molecular Liquids

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Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Muñoz

Bilyy

Biermann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

130

118

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The critical size for strong interaction of hydrophobic particles with phospholipid bilayers has been predicted to be 10 nm. Because of the wide spreading of nonpolar nanoparticles (NPs) in the environment, we aimed to reveal the ability of living organisms to entrap NPs via formation of neutrophil extracellular traps (NETs). Upon interaction with various cell types and tissues, 10-to 40-nmsized NPs induce fast (<20 min) damage of plasma membranes and instability of the lysosomal compartment, leading to the immediate formation of NETs. In contrast, particles sized 100-1,000 nm behaved rather inertly. Resulting NET formation (NETosis) was accompanied by an inflammatory reaction intrinsically endowed with its own resolution, demonstrated in lungs and air pouches of mice. Persistence of small NPs in joints caused unremitting arthritis and bone remodeling. Small NPs coinjected with antigen exerted adjuvant-like activity. This report demonstrates a cellular mechanism that explains how small NPs activate the NETosis pathway and drive their entrapping and resolution of the initial inflammatory response.nanoparticles | size | neutrophils | NETosis | inflammation

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Sensing Inside the Living Cells

Cited by 3 publications

References 168 publications

Optical Chemical Nanosensors in Clinical Applications

Optical Chemical Nanosensors in Clinical Applications

Monitoring the microenvironment inside polymeric micelles using the fluorescence probe 6-propionyl-2-dimethylaminonaphthalene (PRODAN)

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

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