Cell Reports volume 3, issue 5, P1640-1650 2013 DOI: 10.1016/j.celrep.2013.04.016 View full text
Prashant Sharma, Satoru Yamada, Margaret Lualdi, Mary Dasso, Michael R. Kuehn

Abstract: SUMMARY Posttranslational modification with small ubiquitin-like modifier (Sumo) regulates numerous cellular and developmental processes. Sumoylation is dynamic with deconjugation by Sumo-specific proteases (Senps) regulating steady-state levels. Different Senps are found in distinct subcellular domains, which may limit their deconjugation activity to colocalizing Sumo-modified proteins. In vitro, Senps can discriminate between the different Sumo paralogs: Sumo1 versus the highly related Sumo2 and Sumo3 (Sumo…

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