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Cited by 43 publications
(40 citation statements)
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References 7 publications
(40 reference statements)
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“…However, this approach risks false negatives arising from genuine SNCs that do not express canonical markers, and false positives due to biological use of these proteins outside of senescence. For example, some speculate that macrophages recruited to SNCs as part of immune surveillance make up a large portion of p16 Ink4a -positivity and SA β-gal signal in aged tissue without being senescent per se (174)(175)(176).…”
Section: Discussionmentioning
confidence: 99%
“…However, this approach risks false negatives arising from genuine SNCs that do not express canonical markers, and false positives due to biological use of these proteins outside of senescence. For example, some speculate that macrophages recruited to SNCs as part of immune surveillance make up a large portion of p16 Ink4a -positivity and SA β-gal signal in aged tissue without being senescent per se (174)(175)(176).…”
Section: Discussionmentioning
confidence: 99%
“…Senescence affects most cell types including macrophages, which serve as sentinels against infection (Franceschi et al, 2000). Inflamm-aging has also been designated as macroph-aging, due to the important role played by this cell type in secreting proinflammatory mediators at the local and systemic level (Prattichizzo et al, 2016). Notably, studies of the modulation of circulating monocyte/macrophage polarization during aging suggest different age-related trends for the M2 subset (Costantini et al, 2018).…”
Section: Older Men Show Accelerated Biological Agingmentioning
confidence: 99%
“…With steady accumulation of senescent cells, senescence eventually occurs at the cellular level and then Macrophage senescence is inextricably associated with inflammaging, bridging SASPs and inflammasomes. p16 Ink4a has been implicated in macrophage activation or polarization [29], and SASPs induce senescence-like phenotypes in macrophages [30]. Senescence-related changes in macrophages are speculated to generally represent their proinflammatory activation [31], i.e., proinflammatory effects of macrophages are accompanied by inflammaging to some extent.…”
Section: Macrophage Senescence and Inflammaging: An Intimate Relationmentioning
confidence: 99%