Seminal ‘priming’ for protection from pre-eclampsia—a unifying hypothesis

Robertson, Sarah A.; Bromfield, John J.; Tremellen, Kelton

doi:10.1016/s0165-0378(03)00052-4

Cited by 121 publications

(86 citation statements)

References 43 publications

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“…Importantly, there is evidence that vitamin D plays many important roles in pregnancy, and maternal vitamin D deficiency has been associated with preeclampsia [3]. This is probably not limited to pregnancy, as vitamin D has been shown to affect blood pressure by influencing a number of different mechanisms involved in the regulation of arterial blood pressure [30], and therefore vitamin D deficiency may predispose to hypertensive disorders of pregnancy [4,31,32]. Furthermore, the expression of VDR in the placenta suggests a role for this hormone during pregnancy [33,34].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

et al. 2012

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Hypertension is the most common medical disorder in pregnancy, and a leading cause of maternal and neonatal morbidity and mortality. Vitamin D endocrine system has important influence on immune modulation and endothelial function, which play a role in preeclampsia (PE) and gestational hypertension (GH). Vitamin D receptor (VDR) is present in a large variety of cell types, including placental cells. We examined whether there is an association between VDR polymorphisms (FokI, ApaI and BsmI) with PE or with GH. Restriction fragment length polymorphism techniques were used to genotype 529 pregnant (154 with GH, 162 with PE, and 213 healthy pregnant-HP). VDR haplotype frequencies were inferred using the PHASE 2.1 program. We found similar genotype distributions for the three VDR polymorphisms in both PE and GH groups compared with the HP group (all P [ 0.05). In parallel with these findings, the VDR haplotype frequency distribution was similar in both PE and GH groups compared with the HP group (all P [ 0.05). Our results showing no significant association between VDR polymorphisms or haplotypes with PE or GH suggest that genetic variations in VDR do not predispose to hypertensive disorders of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

et al. 2012

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“…Studies have also shown that semen exposure in women is advantageous to pregnancy outcome, the use of barrier contraception methods and the period of cohabitation between couples suggests that chronic semen exposure by an individual can be beneficial to subsequent pregnancies [102]. There is now a large body of evidence to suggest that preeclampsia has male factors, derived from semen, involved in its aetiology [103,104].…”

Section: Seminal Plasma and Pathologies Of Pregnancymentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

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123

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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“…Dysregulation of antigens at the maternal fetal interface may lead to pre-eclampsia and HELLP syndrome. This may be supported by the fact that adequate exposure to paternal antigens in seminal fluid prior to the first pregnancy seems to prevent pre-eclampsia indicating an immunological memory which is most likely stored in T cells [15]- [17].…”

Section: Discussionmentioning

confidence: 96%

A Study of HELLP Syndrome among Cases of Pre-Eclampsia and Eclampsia: Incidence and Correlation of Laboratory Parameters

Tiwari¹,

Bhalavi²,

Nayak³

et al. 2015

OALib

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Objective: To determine the incidence of HELLP syndrome amongst cases of Eclampsia and severe pre-eclampsia admitted to our hospital and to study the correlation of laboratory parameters with the mean arterial pressure (MAP) and with each other. Method: 238 cases of severe pre-eclampsia and eclampsia were studied for their clinical features, laboratory parameters and outcome. Cases were divided into two groups: non HELLP and complete HELLP for comparison of the maternal and perinatal outcome. The levels of Alanine Transaminase (ALT) were compared against other laboratory parameters for correlation. The mean arterial pressures (MAP) of the patients were computed to investigate whether its levels had any correlation with the derangement of ALT. Statistical analysis was done in SPSS software and spearman's correlation was run for the laboratory parameters. Results: No significant difference was seen in the maternal and perinatal mortality in the two groups. ALT showed no correlation with MAP as with LDH, platelets and hemoglobin and a weak but significant correlation with the parameters of renal function. Conclusion: Our population shows a low incidence of HELLP syndrome; the hepatic dysfunction correlates with the renal dysfunction without any correlation with the MAP.

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Seminal ‘priming’ for protection from pre-eclampsia—a unifying hypothesis

Cited by 121 publications

References 43 publications

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Seminal fluid and reproduction: much more than previously thought

A Study of HELLP Syndrome among Cases of Pre-Eclampsia and Eclampsia: Incidence and Correlation of Laboratory Parameters

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