Semiconductor II-VI Quantum Dots with Interface States and Their Biomedical Applications

Torchynska, Tetyana; Vorobiev, Yuri V.

doi:10.5772/20628

Cited by 23 publications

(26 citation statements)

References 139 publications

(171 reference statements)

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“…Raman scattering spectra were investigated with the goal to study the impact of compressive strains [33,34] and the oxidation or degradation processes at the QD bioconjugation [32,35] ) has related to the phonon confinement effect in small QDs [6,35]. The peak at 345.3 cm ) is related to the phonon confinement effect in thin ZnS shell [6,35,36].…”

Section: The Bioconjugation Study Ofmentioning

confidence: 99%

“…The key issue for nanoparticles intended for biological use is to ensure their stability, which suggests the formation of core-shell structures with a certain enveloping layer required to isolate a nanoparticle [6]. The core defines the main properties of the system-it may be the material with outstanding luminescence or magnetic properties for the precise detection of particle's location inside the body.…”

Section: Introductionmentioning

confidence: 99%

“…In contrary, the II-VI semiconductor core/shell QDs are characterized by the high-photoluminescence (PL) quantum yield (up to 75%) [11][12][13]. Surface-passivized II-VI QDs are highly stable against photo bleaching and are characterized by narrow, symmetric emission peaks with the half width about 25-30 nm [6].…”

Section: Introductionmentioning

confidence: 99%

“…The development of a blood test, using the optical methods, which permits early diagnosis, would be a great advance in the management of cancer disease. Note that the core/shell CdSeTe/ZnS QDs with near-infrared (IR) emission (780-800 nm) are very interesting for biological applications owing to the possibility of animal imaging in vivo due to the low absorption of IR light by an animal tissue [6,14,15]. At the same time, the chemical behavior of Cd/Se/Te components of QDs in the biological system is still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…A set of publications, related to the study of QD bioconjugation using PL spectroscopy, revealed that the emission intensity of QDs decreased [12,24,25] or increased [22,26] owing to the energy exchange between the QDs and the biomolecules. Thus, the QD luminescence intensity depends on the concentration of attached biomolecules, promising the QD application as a protein sensor as well [6]. However, the limits of biomolecule detection are not very sensitive.…”

Section: Introductionmentioning

confidence: 99%

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Physical Reasons of Emission Varying in CdSe/ZnS and CdSeTe/ZnS Quantum Dots at Bioconjugation to Antibodies

Torchynska¹

2015

Quantum Dots - Theory and Applications

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Photoluminescence, its excitation power dependence, and Raman scattering spectra have been studied in CdSe/ZnS and CdSeTe/ZnS QDs for the nonconjugated states and after the QD conjugation to the anti-Interleukin-10, Human papilloma virus and Pseudo rabies virus antibodies. The QD bioconjugation to charged antibodies stimulates the "blue" energy shift of PL bands related to exciton emission in the CdSe or CdSeTe cores. The "blue" energy shift of PL spectrum in bioconjugated CdSe/ZnS QDs has been attributed to the electronic quantum confined effects stimulated by decreasing the effective QD size at its bioconjugation to charged antibodies. It was shown that the attachment of a charge deals with the antibody to the exterior shell of CdSe/ZnS QDs, leads to blocking away a fraction of core's volume. The energy band diagrams of CdSeTe/ZnS QDs in the nonconjugated and bioconjugated states have been designed, which permit to explain the types of optical transitions in QDs and their transformations at the QD bioconjugation. It is shown that the change of energy band profile and the "blue" shift of QD energy levels, owing to the change of potential barrier at the QD surface, are the dominant reasons of PL spectrum transformation in the double core CdSeTe/ZnS QDs conjugated to charged antibodies. Better understanding the QD bioconjugation to specific antibodies is expected to produce the major advances in biology and medicine and can be a powerful technique for early medical diagnostics.

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Section: The Bioconjugation Study Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Physical Reasons of Emission Varying in CdSe/ZnS and CdSeTe/ZnS Quantum Dots at Bioconjugation to Antibodies

Torchynska¹

2015

Quantum Dots - Theory and Applications

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Interaction and energy transfer studies between bovine serum albumin and CdTe quantum dots conjugates: CdTe QDs as energy acceptor probes

et al. 2016

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In this paper, a systematic investigation of the interaction of bovine serum albumin (BSA) with water-soluble CdTe quantum dots (QDs) of two different sizes capped with carboxylic thiols is presented based on steady-state and time-resolved fluorescence measurements. Efficient Förster resonance energy transfer (FRET) was observed to occur from BSA donor to CdTe acceptor as noted from reduction in the fluorescence of BSA and enhanced fluorescence from CdTe QDs. FRET parameters such as Förster distance, spectral overlap integral, FRET rate constant and efficiency were determined. The quenching of BSA fluorescence in aqueous solution observed in the presence of CdTe QDs infers that fluorescence resonance energy transfer is primarily responsible for the quenching phenomenon. Bimolecular quenching constant (k ) determined at different temperatures and the time-resolved fluorescence data provide additional evidence for this. The binding stoichiometry and various thermodynamic parameters are evaluated by using the van 't Hoff equation. The analysis of the results suggests that the interaction between BSA and CdTe QDs is entropy driven and hydrophobic forces play a key role in the interaction. Binding of QDs significantly shortened the fluorescence lifetime of BSA which is one of the hallmarks of FRET. The effect of size of the QDs on the FRET parameters are discussed in the light of FRET parameters obtained.

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Synthetic Developments of Semiconductor Quantum Dot for Biological Applications

Barik¹

2022

Application of Quantum Dots in Biology and Medicine

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Semiconductor II-VI Quantum Dots with Interface States and Their Biomedical Applications

Cited by 23 publications

References 139 publications

Physical Reasons of Emission Varying in CdSe/ZnS and CdSeTe/ZnS Quantum Dots at Bioconjugation to Antibodies

Physical Reasons of Emission Varying in CdSe/ZnS and CdSeTe/ZnS Quantum Dots at Bioconjugation to Antibodies

Interaction and energy transfer studies between bovine serum albumin and CdTe quantum dots conjugates: CdTe QDs as energy acceptor probes

Synthetic Developments of Semiconductor Quantum Dot for Biological Applications

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