Semen Characteristics of Gossypol-Treated Langurs (Presbytis Entellus Entellus Dufresne)

Abstract

Gossypol isolated from cottonseed was fed to sexually adult male langurs at 50 and 100 mg/kg body weight per day for 90 days. Semen was collected every 2 wk, and the observations made on semen characteristics showed gossypol's detrimental effect The gossypol administration caused a significant decline in percent sperm cells motility and a significant rise in abnormalities. The semen characteristics returned to normal levels during a 180-day recovery period following the discontinuation of gossypol treatment. A clear relationship exists between the inhibition of sperm cell motility and dose as well as duration of gossypol treatment. The testicular biopsies taken from two langurs after 90 days of gossypol treatment showed normal histoarchitecture at both the dose levels.

Anti‐spermatogenic activity of malvidin chloride in langur monkeys (Presbytis entellus entellus Dufresne)

“…It belongs to the family Malvaceae, another member of which, cottonseed, has yielded gossypol, which has pronounced male anti-fertility effects. As it is known that gossypol is a colouring matter present in cottonseed and it is this that is responsible for causing infertility in man and animals (Coulson et al, 1980;Prasad & Diczfaluzy, 1982;Qian, 1984;Bhargava, 1984b), it was considered worthwhile studying the male anti-fertility effects of malvidin chloride, the colouring agent in flowers of M . conzattii, in langur monkeys.…”