Selling Safety—Lessons From Muraglitazar

Brophy, James M.

doi:10.1001/jama.294.20.jed50074

JAMA

2005

DOI: 10.1001/jama.294.20.jed50074

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Selling Safety—Lessons From Muraglitazar

James M. Brophy¹

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Cited by 18 publications

(18 citation statements)

References 5 publications

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“…Lastly, the strength of several associations was limited since some analyses were restricted by the number of incident events. Therefore, we used composite variables to increase the statistical power of our analyses 48 …”

Section: Discussionmentioning

confidence: 99%

Impact of direct‐acting antiviral treatment for hepatitis C on cardiovascular diseases and extrahepatic cancers

Lam

¹

,

Fontaine

²

,

Lapidus

³

et al. 2022

Pharmacoepidemiology and Drug

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Lastly, the strength of several associations was limited since some analyses were restricted by the number of incident events. Therefore, we used composite variables to increase the statistical power of our analyses 48 …”

Section: Discussionmentioning

confidence: 99%

Impact of direct‐acting antiviral treatment for hepatitis C on cardiovascular diseases and extrahepatic cancers

Lam

¹

,

Fontaine

²

,

Lapidus

³

et al. 2022

Pharmacoepidemiology and Drug

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In particular, readers need information on deaths, and on harms that can be lethal, such as thromboses causes by COX-2 inhibitors. In the drug literature, there is plenty of evidence of flawed research [34][35][36][37][38][39][40][41][42][43], ghost-written articles [24,25,[44][45][46][47], intimidation of researchers [44,45,[48][49][50][51][52][53][54][55][56] and misleading and false statements in research papers and marketing [24,[44][45][46][47][57][58][59][60][61][62][63][64][65].…”

Section: Discussionmentioning

confidence: 99%

Unbalanced reporting of benefits and harms in abstracts on rofecoxib

Fonseca‐Alves

¹

,

Corrêa

²

,

Santos-Júnior

³

et al. 2010

Eur J Clin Pharmacol

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In 2005, an FDA advisory committee recommended approval of an antidiabetes drug, muraglitazar, but independent researchers who analyzed the submitted trial data found that the original analyses supporting the FDA application were flawed, and that the drug was harmful [44,45]. …”

Section: Non-transparent Data On Lethal Harmsmentioning

confidence: 99%

Why we need easy access to all data from all clinical trials and how to accomplish it

Gøtzsche

¹

2011

Trials

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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