Sellar plasmacytomas masquerading as pituitary adenomas: A systematic review

DiDomenico, Joseph D.; Ampie, Leonel; Choy, Winward; Lamano, Jonathan B.; Oyon, Daniel E.; Kesavabhotla, Kartik; Bloch, Orin

doi:10.1016/j.jocn.2018.01.022

Cited by 13 publications

(21 citation statements)

References 7 publications

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“…As MRI revealed a lesion compatible with pituitary macroadenoma, at first, the plasmacytoma was not suspected, and the presumptive diagnosis of nonfunctioning pituitary adenoma was established. By analyzing similarly published data from literature, it has been estimated that only a small proportion of patients diagnosed with intrasellar tumors, including our patient, had a primary intrasellar plasmacytoma (3,8,12). As previously reported, approximately 50% of cases of plasmacytoma without evidence of multiple myeloma at the diagnosis progress to overt multiple myeloma within 10 years, and 10% of them recur with a plasmacytoma (13), thereby underlining the importance of a correct and timely diagnosis in the management of these patients.…”

Section: Discussionsupporting

confidence: 58%

“…The most common age of patients at diagnosis is, on average, 60 years. Uncommon hormonal abnormalities may be present, among which hyperprolactinemia and sexhormone imbalance are the most frequent (8), although in many cases, as in our patient, anterior pituitary function is not compromised.…”

Section: Discussionmentioning

confidence: 51%

“…Intrasellar plasmacytoma belongs to solitary plasmacytoma, a rare condition which is often misdiagnosed as pituitary adenoma. As a rare disorder, only 45 cases of plasmacytoma have been reported in the literature, with the first case reported in 1970 by pathologic post-mortem diagnosis (3,7,8). The most common age of patients at diagnosis is, on average, 60 years.…”

Section: Discussionmentioning

confidence: 99%

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Non-Functional Pituitary Tumors: a Misleading Presentation of an Intrasellar Plasmacytoma

et al. 2019

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Intrasellar plasmacytoma is a rare pituitary tumor, which originates from monoclonal plasma cells in a single lesion. Knowledge of its features comes from case reports only. Here, we present an interesting case of a 77-year-old woman with a presumptive diagnosis of nonfunctioning pituitary adenoma, as based on both clinical and radiological examinations. Following endoscopic endonasal transsphenoidal surgery, the definitive diagnosis of intrasellar plasmacytoma was made by immunohistochemical analysis of the sellar mass. Intrasellar plasmacytoma is rare, but it should be evaluated in the differential diagnosis of a pituitary mass due to its different therapeutic approach and prognosis, since it can frequently progress to multiple myeloma.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Non-Functional Pituitary Tumors: a Misleading Presentation of an Intrasellar Plasmacytoma

et al. 2019

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“…12 Like in our case the LPM does not have typical imaging features of a meningioma so it can mimic intracranial inflammatory condition or brain neoplasm. Intracranial plasma cell granulomas 13, 14 and dural plasmacytoma 15,16 are often confused with meningiomas at the radiographic level. Moreover, inflammatory pseudo tumors, inflammatory fibrous histiocytomas, lymphomatoid granulomatosis and sinus histiocytosis with massive lymphadenopathy are also considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Lymphoplasmacyte rich meningioma: a rare variant of meningioma mimicking diffuse granulomatous disease with leptomeningeal spread

Shah¹,

Karki²,

Poudel³

et al. 2020

Nep J Neurosci

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Lymphoplasmacyte-rich meningioma is a rare variant of World Health Organization (WHO) Grade I meningioma, which may present as diffuse granulomatous disease with leptomeningeal spread. Here, we report a case of 61 years old man who presented with gradual onset of progressive quadriperesis. Patient was initially treated with antitubercular medications as imaging studies and serum markers were suggestive of granulomatous lesion. Surgical intervention was adviced as patient did not respond to medical management. Histopathology and immunohistochemistry confirmed the diagnosis of lymphoplasmacyte-rich meningioma. This meningioma can present as diffuse leptomeningeal infiltrative lesion involving both the hemispheres and all the tentorial surfaces mimicking inflammatory lesion. Tuberculosis is very common in our part and the diffuse infiltrative nature oflymphoplasmacyte-rich meningioma with similar radiological features of these two pathologies may confuse and delay the diagnosis. Recognition of this entity is of utmost importance as it guides proper management.

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“…Plasmacytomas of the sellar region were first reported in 1970 by postmortem pathologic diagnosis, an observation that predates a case from 1977 that was previously attributed as the first. 1 They are rare tumors localized on the sellar region arising from plasma cells. 2 It is believed that the entity originates from the surrounding mucosa of the sellar region and clivus, which can be locally aggressive.…”

Section: Introductionmentioning

confidence: 99%

Huge Sellar Plasmacytoma as Differential Diagnosis of Invasive Pituitary Adenoma: A Case Report

Filgueira-Junior

Dornelas

Barboza-Filho

et al. 2021

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Sellar plasmacytomas are rare tumors arising from plasma cells. They are often misdiagnosed as adenomas. We report the case of a 63-year-old woman with headache, cranial nerve III palsy and decreased visual acuity. Imaging revealed an extensive lesion centered on the clivus, extending to the cavernous sinus bilaterally and into the sphenoid sinus. The hormonal tests were compatible with panhypopituitarism and mild hyperprolactinemia. The first hypothesis was invasive pituitary adenoma. Partial resection was achieved, and the immunohistochemical evaluation was compatible with plasmacytoma. After a few weeks, she developed lumbar and hip pain, and the imaging confirming osteolytic lesions. The final diagnosis was multiple myeloma.

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Sellar plasmacytomas masquerading as pituitary adenomas: A systematic review

Cited by 13 publications

References 7 publications

Non-Functional Pituitary Tumors: a Misleading Presentation of an Intrasellar Plasmacytoma

Non-Functional Pituitary Tumors: a Misleading Presentation of an Intrasellar Plasmacytoma

Lymphoplasmacyte rich meningioma: a rare variant of meningioma mimicking diffuse granulomatous disease with leptomeningeal spread

Huge Sellar Plasmacytoma as Differential Diagnosis of Invasive Pituitary Adenoma: A Case Report

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