Self-reported long COVID-19 symptoms are rare among vaccinated healthcare workers

AlBahrani, Salma; AlBarrak, Ali; AlGubaisi, Nawal; Alkurdi, Hamoud; Alburaiki, Dalia; AlGhamdi, Abdulrahaman; AlOthaiqy, Mohammed; Tayeb, Sarah; Tayeb, Nesreen; Abdraboh, Salimah; Khairi, Amani; Alshareef, Lujain; AlHarbi, Asma; AlRabeeah, Saad; Alqahtani, Abdullah S.; Alqahtani, Jaber S.; Hakami, Fatimah Hassan; Al-Maqati, Thekra N.; Alkhrashi, Sausan Abdulrahman; Almershad, Meshael Musaed; AlAbbadi, Asmaa; Hakami, Mariam Hassan; Faqihi, Osama; Altawfiq, Kauthar Jaffar A.; Jebakumar, Arulanantham Zachariah; Al-Tawfiq, Jaffar A.

doi:10.1016/j.jiph.2023.05.037

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…The vaccination impact on individuals with existing long-COVID-19 symptoms is emerging and data showed changes in symptoms severity while others show no correlation between symptoms and vaccination status [ 18 ]. As known, low level of evidence (grade III, case-controls, cohort studies) indicates that vaccination before COVID-19 infection may reduce the risk of post-COVID-19 symptoms [ 18 – 20 ]. A previous study showed that vaccination before SARS-CoV-2 acute infection reduced long COVID-19 symptoms [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

Adly,

Saleh,

Garout

et al. 2023

J Epidemiol Glob Health

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Introduction Multiple studies investigated the endurance and occurrence of symptoms three months after SARS-CoV-2 infection. This study examines the possible effects of COVID-19 vaccination on the persistence of post-recovery symptoms. Patients and Methods A cross-sectional survey was conducted in Saudi Arabia to evaluate 14 prevalent long COVID-19 symptoms among vaccinated individuals. Patients self-reported their acute COVID-19 experience, demographic information, chronic conditions, vaccine history, and persistent symptoms. Results Of the 484 patients, four respondents were excluded from the study as they had not received the vaccine, and 111 (23.1%) were vaccinated but did not get infected and were also excluded. The remaining 369 (76.9%) reported COVID-19 and a vaccination and thus they were included in the study. The occurrence of post-COVID-19 symptoms was reported in 59 (16.1%) for ≤ 3 months, 202 (54.8%) experienced persistent symptoms 3–6 months, and 108 (29.1%) reported symptoms lasting > 6 months. In relation to age group, persistent symptoms 3–6 months after recovery was more common in those > 50 years and symptoms lasting > 6 months were more common in 30–50 years of age (p < 0.001). Persistence of symptoms for 3-6 months was more common in those who were infected prior to vaccination compared to those who were infected after vaccination (P < 0.001). Of the included patients, 323 (87.5%) rated their health as good, 41 (11.1%) considered it fair, and 5 (1.4%) described their well-being as poor or terrible. Conclusion The study provides information of persistent symptoms in vaccinated individuals who had recovered from COVID-19 and highlights the need for targeted interventions to alleviate post-COVID-19 symptoms. The study is limited by its reliance on self-reported data and potential selection bias. Future research is needed to understand the mechanisms underlying persistent symptoms in vaccinated individuals and to identify effective interventions for long COVID.

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Section: Discussionmentioning

confidence: 99%

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

Adly,

Saleh,

Garout

et al. 2023

J Epidemiol Glob Health

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“…Clinically, Omicron variant induced less severe acute illness than its predecessors, and certain studies reported a reduced incidence of post-acute phase impacts [13][14][15][16][17][18][19], both in adults and children [20][21][22][23][24]. Nevertheless, conflicting data have surfaced in the literature [25], and the potential influence of prior vaccination remains uncertain [26][27][28].Valuating the genuine repercussions of SARS-CoV-2 infection in the realm of LONG COVID following the acute phase proves intricate due to myriad factors. Discrepancies in defining criteria, observation durations, encompassed medical conditions, and symptom dynamics may account for disparities among reported studies.…”

Section: Introductionmentioning

confidence: 99%

Impact of Long SARS-CoV-2 Omicron on Health Care Burden: A Case-control Comparative Study with the Pre-Omicron Waves (Preprint)

Redon,

Valdivieso-Martinez,

Lopez-Sanchez

et al. 2023

JMIR Public Health and Surveillance

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Background:The global population has been profoundly affected by the SARS-CoV-2 pandemic, resulting in elevated morbidity and mortality. Following the initial acute phase of illness, healthcare resource utilization has escalated among individuals with SARS-CoV-2 infection, attributed to persistent symptoms or the emergence of new illnesses. Objective:The primary aim of this study was to ascertain the enduring consequences of SARS-CoV-2 virus infection on both the incidence of new diagnoses and the utilization of healthcare resources among patients, within the context of the Omicron pandemic. A case-control investigation was conducted with the aim of drawing comparisons between the Omicron wave and the preceding pre-Omicron waves.Methods: This matched retrospective cohort study included patients of all ages from two healthcare Departments. Patients were matched on control and were followed-up for 6 months after SARS-CoV-2 infection. Previous vaccination, new diagnosis (CIE10) and use of health care resources were recorded.Results: In the study, a total of 41,577 patients with a history of prior COVID infection were included, alongside an equivalent number of controls. This cohort encompassed 33,249 adults aged >17 years and 8,328 youths aged <18 years. Notably, our analysis revealed the identification of forty new diagnoses. The incidence rate per 100 patients over a six-month period stood at 27.2 for vaccinated and 25.1 for unvaccinated adults (p=0.09), while among youths, the corresponding rates were 25.7 for vaccinated and 36.7 for unvaccinated individuals (P<001). Overall, the incidence of new diagnoses was notably higher in patients when compared to controls. Additionally, vaccinated patients exhibited a reduced incidence of new diagnoses, particularly among women (P<001) and younger patients (P<001), irrespective of the number of vaccine doses administered and the duration since the last dose. Furthermore, an increase in the utilization of healthcare resources was observed in both adult and adolescent patients, albeit with lower figures noted in vaccinated individuals. In the comparative analysis between the Pre-Omicron and Omicron waves, the incidence of new diagnoses was higher in the former; however, distinct patterns of diagnosis were evident. Similarly, healthcare resource utilization, encompassing primary care, specialist, and emergency services, was more pronounced in the Pre-Omicron wave. Conclusions:The rise in new diagnoses following SARS-CoV-2 infection warrants attention due to its potential implications for health systems, which may necessitate the allocation of supplementary resources. The absence of vaccination protection presents a challenge to the healthcare system.

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Impact of Long SARS-CoV-2 Omicron on Health Care burden. Comparative with the Pre-Omicron waves. A Case Control Study (Preprint)

Redon,

Valdivieso-Martinez,

Lopez-Sanchez

et al. 2023

Preprint

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BACKGROUND The global population has been profoundly affected by the SARS-CoV-2 pandemic, resulting in elevated morbidity and mortality. Following the initial acute phase of illness, healthcare resource utilization has escalated among individuals with SARS-CoV-2 infection, attributed to persistent symptoms or the emergence of new illnesses. OBJECTIVE The primary aim of this study was to ascertain the enduring consequences of SARS-CoV-2 virus infection on both the incidence of new diagnoses and the utilization of healthcare resources among patients, within the context of the Omicron pandemic. A case-control investigation was conducted with the aim of drawing comparisons between the Omicron wave and the preceding pre-Omicron waves. METHODS This matched retrospective cohort study included patients of all ages from two healthcare Departments. Patients were matched on control and were followed-up for 6 months after SARS-CoV-2 infection. Previous vaccination, new diagnosis (CIE10) and use of health care resources were recorded. RESULTS In the study, a total of 41,577 patients with a history of prior COVID infection were included, alongside an equivalent number of controls. This cohort encompassed 33,249 adults aged >17 years and 8,328 youths aged <18 years. Notably, our analysis revealed the identification of forty new diagnoses. The incidence rate per 100 patients over a six-month period stood at 27.2 for vaccinated and 25.1 for unvaccinated adults (p=0.09), while among youths, the corresponding rates were 25.7 for vaccinated and 36.7 for unvaccinated individuals (P<001). Overall, the incidence of new diagnoses was notably higher in patients when compared to controls. Additionally, vaccinated patients exhibited a reduced incidence of new diagnoses, particularly among women (P<001) and younger patients (P<001), irrespective of the number of vaccine doses administered and the duration since the last dose. Furthermore, an increase in the utilization of healthcare resources was observed in both adult and adolescent patients, albeit with lower figures noted in vaccinated individuals. In the comparative analysis between the Pre-Omicron and Omicron waves, the incidence of new diagnoses was higher in the former; however, distinct patterns of diagnosis were evident. Similarly, healthcare resource utilization, encompassing primary care, specialist, and emergency services, was more pronounced in the Pre-Omicron wave. CONCLUSIONS The rise in new diagnoses following SARS-CoV-2 infection warrants attention due to its potential implications for health systems, which may necessitate the allocation of supplementary resources. The absence of vaccination protection presents a challenge to the healthcare system.

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Self-reported long COVID-19 symptoms are rare among vaccinated healthcare workers

Cited by 3 publications

References 30 publications

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

Impact of Long SARS-CoV-2 Omicron on Health Care Burden: A Case-control Comparative Study with the Pre-Omicron Waves (Preprint)

Impact of Long SARS-CoV-2 Omicron on Health Care burden. Comparative with the Pre-Omicron waves. A Case Control Study (Preprint)

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