Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid

Strambini, Lucanos Marsilio; Longo, Angela; Scarano, Simona; Prescimone, Tommaso; Palchetti, Ilaria; Minunni, Maria; Giannessi, D.; Barillaro, Giuseppe

doi:10.1016/j.bios.2014.11.010

Cited by 114 publications

(73 citation statements)

References 26 publications

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“…An extra pump can be utilized to change the speed of drug solution carefully and refill the drug without removing the MNs, which makes continuous delivery of the drug possible [99]. Hollow MNs are also widely used to collect ISF [34] and blood [18]. In addition, a rapid analysis system can be precisely aligned on the outlet of the hollow MNs to discriminate analytes in the collected biological fluids (ISF or blood).…”

Section: Hollow Mnsmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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Section: Hollow Mnsmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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“…Based on the extracted ISF, the researchers demonstrated that transcriptomic and proteomic signature profiles in skin ISF were similar to those in serum 17d. The hollow MNs can be further integrated with a biosensor for real‐time accurate detection of the specific biomarker, such as glucose . The second way is to apply solid MNs to create micropores on the skin, through which ISF can be collected with vacuum.…”

Section: Biomedical Applications Of Microneedlesmentioning

confidence: 99%

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Chang

Zheng

Chew

et al. 2020

Adv Materials Technologies

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These MN platforms have been intensively explored for transdermal drug delivery in the treatment of both local and systemic diseases. [1c,12] They function as carriers for small molecular drugs, [13] peptides and proteins (e.g., insulin, vaccines, and antibodies), [8a,14] oligonucleotides, [11d] and nanomedicines [10a,b] and deliver them into peripheral tissues like skin, eyes, mouth, vascular wall, vagina etc. [15] Recently, MNs also receive attention from medical diagnosis and health monitoring, as they can easily access skin interstitial fluid (ISF) that is formed by blood transcapillary filtration and contains numerous biomarkers of clinical interest. [16] They can either directly sample ISF for postanalysis, [9e,11b,17] or integrate with sensing components for in situ real-time monitoring. [18] This article summarizes the recent advances in the MN field including the design, fabrication, and biomedical applications (Figure 1). The challenges and future perspectives are also discussed.

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“…However novel interesting solutions for new types of glucose sensors can be still realized using glucose oxidase. Two clear examples are represented by the works of Strambini et al and Habtamu and Ugo [52,53]. The first approach reports the development of a self-powered microneedle-based transdermal biosensor for the real-time measurement of glycaemia in interstitial fluid.…”

Section: Biosensorsmentioning

confidence: 99%

Chemical Sensors and Biosensors in Italy: A Review of the 2015 Literature

Compagnone

Francia

Natale

et al. 2017

Sensors

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The contributions of Italian researchers to sensor research in 2015 is reviewed. The analysis of the activities in one year allows one to obtain a snapshot of the Italian scenario capturing the main directions of the research activities. Furthermore, the distance of more than one year makes meaningful the bibliometric analysis of the reviewed papers. The review shows a research community distributed among different scientific disciplines, from chemistry, physics, engineering, and material science, with a strong interest in collaborative works.

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Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid

Cited by 114 publications

References 26 publications

Engineering Microneedles for Therapy and Diagnosis: A Survey

Engineering Microneedles for Therapy and Diagnosis: A Survey

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Chemical Sensors and Biosensors in Italy: A Review of the 2015 Literature

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