Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation

Kassem, Ahmed Alaa; Mohsen, Amira Mohamed; Ahmed, Reham Samir; Essam, Tamer

doi:10.1016/j.molliq.2016.02.081

Cited by 144 publications

(105 citation statements)

References 87 publications

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“…[170][171][172][173][174][175] Self Nanoemulsifying Drug Delivery System (SNEDDS) SNEDDS is a lipid-based anhydrous isotropic mixture of oil, surfactant(s) and cosurfactant(s) with a particle size of 20-200 nm ( Figure 11). 9,176 It produces fine oil-in-water nanoemulsions upon gentle agitation after dilution in aqueous media, such as gastrointestinal fluids; thus, it can be given orally in soft or hard gelatin capsules. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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“…The optimum SNEDDS formula did not change visible appearance which showed good stability at various storage conditions (table 6). Nanoemulsion is more stable than an emulsion, SNEDDS that will form nanoemulsion must be thermodynamically stable with the characteristic of not experiencing precipitation, cracking, or creaming [43]. The TEM of the optimum formula is presented in fig.…”

Section: Thermodynamic Stabilitymentioning

confidence: 99%

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

et al. 2019

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Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

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“…The formed emulsion were allowed to stand for 2 h and seen for phase separation. Then the transmittance was determined using UV spectrophotometer at 638 nm against distilled water as the blank (Kassem et al, 2016).…”

Section: Selection Of Surfactantmentioning

confidence: 99%

“…From this mixture, 25μl was added to 25 ml of distilled water in a standard lask. The ease of emulsi ication was checked in a similar fashion as described above (Kassem et al, 2016).…”

Section: Selection Of Co-surfactantmentioning

confidence: 99%

Self nano emulsifying solid of clopidogrel - developement, characterization, evaluation and effect on bioavailability

Manoharan¹,

Somaskandan²

2019

ijrps

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The aim of the present study is the development and characterization of self-nano emulsifying drug delivery systems (SNEDDSs) to improve the rate of dissolution of poorly water-soluble anti-platelet agent clopidogrel bisulfate. The solubility was estimated in various vehicles to select proper components and compositions. Cinnamon oil (as oil), Tween 80 (as a surfactant), polyethylene glycol 400 (as co-surfactant) and Water is used to construct pseudo-ternary phase diagrams. Stability, dispersibility and robustness to dilution were performed to optimize formulations by using the phase diagram. Formulations were prepared with different composed of cinnamon oil, Tween 80 and PEG 400 (Smix) ratios. The globule size of the optimized system was less than 200 nm, which could be an accepted nanoemulsion size range. The selected formulation F 7 SNEEDS of z-average size was 140.8 nm, and zeta potential was -28.6. In vitro, drug release studies showed a significantly enhanced rate of dissolution of F 7 SNEDDS when compared to the marketed formulation.

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Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation

Cited by 144 publications

References 87 publications

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

Self nano emulsifying solid of clopidogrel - developement, characterization, evaluation and effect on bioavailability

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