Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Nagaraj, Lavanya V.; Fangman, William; White, Wain L.; Woosley, John T.; Prose, Neil S.; Selim, M. Angélica; Morrell, Dean S.

doi:10.1016/j.jaad.2006.06.024

Cited by 31 publications

(49 citation statements)

References 22 publications

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“…4,6,10,15 However, these classic histopathologic diagnostic criteria are usually reported on biopsy specimens taken from papular lesions rather than deep nodules. 9,11 In most of the literature, SHJCM nodules are described as mucinous areas associated with bands of fibrosis in the subcutis. 16 However, these areas, containing arborizing thinwalled vessels and prominent plump to spindle-shaped fibroblasts, may be difficult to identify because fibrosis may be prominent.…”

Section: Discussionmentioning

confidence: 99%

“…5,9 All these features, in particular, the significant subcutaneous involvement, could lead to the diagnosis of fasciitis, especially proliferative fasciitis, or to a nonspecific reactive process. The difficulty with the histopathological diagnosis is illustrated by the fact that our patients and most of the published cases required consultation with experts in soft tissue pathology 5,9,11 to be properly diagnosed. 13 Our first case seems similar to the case reported by Cowen et al, 5 also exhibiting dense fibrous bands in the subcutis and rhabdoid or ganglion-like giant cells, in both nodular excised lesions.…”

Section: Discussionmentioning

confidence: 99%

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Nodular Lesions of Self-healing Juvenile Cutaneous Mucinosis

Barreau

Dompmartin-Blanchère²,

Jamous³

et al. 2012

The American Journal of Dermatopathology

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Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder of unknown origin, which occurs in children in good health. It is characterized by the multiplication of transient cutaneous papules and nodules, mainly located on the head and periarticular areas that spontaneously resolve. Histological features of SHJCM have been well described; therefore, the diagnosis is usually made easily when papules are biopsied. We report a series of 3 new cases of SHJCM presenting mainly with nodular lesions. Histological examination of these nodules showed either lesions consistent with nodular or proliferative fasciitis or nonspecific panniculitis. Mucinous deposits were present but often inconspicuous, so could be disregarded. We wanted to emphasize this misleading presentation because a biopsy for histological examination is always mandatory in cases of proliferating nodules to rule out malignant tumors. Therefore, the diagnosis always requires discussion between pathologists and clinicians to rapidly reassure the parents and avoid inappropriate therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nodular Lesions of Self-healing Juvenile Cutaneous Mucinosis

Barreau

Dompmartin-Blanchère²,

Jamous³

et al. 2012

The American Journal of Dermatopathology

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“…Immunohistochemically, proliferative myositis is diffusely reactive for vimentin and inconsistently reactive for smooth muscle actin and CD68 [43,44]. The differential diagnosis includes self-healing juvenile cutaneous mucinosis in a deep location [45], rhabdomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, and inflammatory myofibroblastic tumor. These can be distinguished by careful attention to clinical and pathologic features and use of immunohistochemistry.…”

Section: Fibrous Umbilical Polypmentioning

confidence: 99%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

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Fibroblastic and myofibroblastic tumors in children and adolescents are a relatively common group of soft tissue proliferations that range from reactive to hamartomatous to neoplastic, with a full spectrum of benign, intermediate, and malignant neoplasms. These lesions are diagnostically challenging because of morphologic and immunohistochemical overlap, despite significant clinical, genetic, and prognostic differences. The fibromatoses are a major subgroup, and all types of fibromatoses can occur in the 1st 2 decades of life. Intermediate and malignant fibroblastic-myofibroblastic tumors are an important group that includes variants of fibrosarcoma and other tumors with recurrent cytogenetic or molecular genetic abnormalities and low metastatic potential. Pathologic examination is enhanced by adjunct techniques, such as immunohistochemistry, cytogenetics, and molecular genetics, although morphology provides the ultimate criteria for a specific diagnosis. This article reviews the clinicopathologic features of fibroblastic and myofibroblastic tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents, the use of diagnostic adjuncts, and differential diagnoses.

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“…Self -healing juvenile cutaneous mucinosis (SHJCM) is a rare disease in dermatology, characterized by sudden onset of papules and nodules located primarily on the face and peri -articular areas of juvenile patients (1). It was described by Colomb (2) and Bonerandi (3) and in the 2 following decades, many other similar cases have been reported (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous mucinosis has various clinical types, such as SHJCM and congenital forms (13). In previous studies, different types of SHJCM, such as the nodular type (14)(15)(16), focal type (6,17), familial type (10), recurrent type (18) with different lesion site presentation (1,15), have been report. Proper approach to this disorder and its mimickers have been presented (3,19,20).…”

Section: Introductionmentioning

confidence: 99%

New Developmental Pattern of Lesions in Alcohol - Related Adult - Type Self - Healing Cutaneous Mucinosis: A Short Report and Review of the Literatures

et al. 2016

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Self -healing juvenile cutaneous mucinosis (SHJCM) is an extremely rare disorder that manifests by sudden onset papules and nodules in juvenile patients that primarily affects the face and peri -articular areas. There are a few reports (less than 20 cases) of Self -healing juvenile cutaneous mucinosis (SHJCM), especially self -healing adult -type cutaneous mucinosis (less than 5 cases). This report presents an alcoholic 23 -year -old male with hard nodular mucinous lesions that was progressively converted to the soft papular type. To the best of the author's knowledge an d based on the literature, this is a new pattern of mucinous lesions in conjunction with alcohol consumption, as a new probable triggering factor. Due to the self -limiting nature of this disorder, the diagnosis should be kept in the physician's mind to prevent unnecessary diagnostic or aggressive therapeutic approaches in acute onset cutaneous mucinous.

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Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Cited by 31 publications

References 22 publications

Nodular Lesions of Self-healing Juvenile Cutaneous Mucinosis

Nodular Lesions of Self-healing Juvenile Cutaneous Mucinosis

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

New Developmental Pattern of Lesions in Alcohol - Related Adult - Type Self - Healing Cutaneous Mucinosis: A Short Report and Review of the Literatures

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