Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages

Yao, Shuncheng; Zheng, Minjia; Wang, Shaobo; Huang, Tian; Wang, Zhuo; Zhao, Yunchao; Yuan, Wei; Zhou, Li; Wang, Zhong Lin; Li, Linlin

doi:10.1002/adfm.202209142

Cited by 38 publications

(34 citation statements)

References 37 publications

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“…However, the poor light penetration ability of these catalysts severely limits the activity enhancement. 7 Similar to its effect on natural protein enzymes, using external electrical stimulation to modulate the electrostatic field can also improve the catalytic activity of nanozymes. 8 However, electrical stimulation often requires the use of high current and large equipment because the external electric fields cannot precisely target the nanozymes.…”

Section: Introductionmentioning

confidence: 99%

Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

Cai

Han

et al. 2023

ACS Nano

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The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity of nanozymes and improve the therapeutic effect of nanozyme catalytic therapy. Piezoelectric materials, which are capable of generating a built-in electric field under ultrasound (US), not only improve the activity of nanozymes but also enable piezoelectric sonodynamic therapy (SDT). In this study, a sonosensitizer based on a Hf-based metal−organic framework (UIO-66) and Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate a built-in electric field inside the materials, which promotes electron− hole separation and produces reactive oxygen species (ROS). The introduction of Au NPs facilitated the electron transfer, which inhibited the recombination of the electron−hole pairs and improved the piezoelectric properties of UIO-66. The value of the piezoelectric constant (d 33 ) increased from 71 to 122 pmV −1 after the deposition of Au NPs. In addition, the intrinsic catalase and peroxidase activities of the Au NPs were increased 2-fold after the stimulation from the built-in electric field induced through US exposure. In vivo and in vitro experiments revealed that the proposed sonosensitizer can kill cancer cells and inhibit tumor growth in mice through the enhanced piezoelectric SDT and nanozyme catalytic therapy. The piezoelectric sensitizer proposed in this work proved to be an efficient candidate that can be used for multiple therapeutic modalities in tumor therapy.

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Section: Introductionmentioning

confidence: 99%

Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

Cai

Han

et al. 2023

ACS Nano

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“…It is known that TME is weakly acidic (pH 6.2–6.8) with a high concentration of H 2 O 2 . According to our recent research studies, the self-powered electric field can promote cancer catalytic therapy through modulation of electron polarization and electron transfer in nanozyme. , To investigate the influence of TENG-enabled electric field on the catalytic properties, we designed a series of experiments (Figure a). It should be mentioned that to exclude the influence from optical absorption of the released DOX, CN-F was used in these experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Compared to conventional power sources, triboelectric nanogenerators (TENGs) as a self-powered electrical source can efficiently convert the mechanical energy of ambient human motions into electrical pulses without the need for external energy supply, breaking through the time and space limitations of traditional equipment. In our recent studies, we have also demonstrated that the TENG-enabled electric field stimulation can promote the catalytic therapy of cancer by generating free radicals. , Moreover, it was reported that the TENG-based therapeutic platforms can assist delivery of therapeutic agents to the disease site through electrical stimulation. , Therefore, TENGs have great potential for application in cancer treatments through the self-powered manner and portable or wearable devices. For this target, how to efficiently deliver electrical stimulation to local tumor tissues is still a great challenge.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 Moreover, it was reported that the TENG-based therapeutic platforms can assist delivery of therapeutic agents to the disease site through electrical stimulation. 7,8 Therefore, TENGs have great potential for application in cancer treatments through the self-powered manner and portable or wearable devices. For this target, how to efficiently deliver electrical stimulation to local tumor tissues is still a great challenge.…”

Section: Introductionmentioning

confidence: 99%

“…In our recent studies, we have also demonstrated that the TENG-enabled electric field stimulation can promote the catalytic therapy of cancer by generating free radicals. 6,7 Moreover, it was reported that the TENG-based therapeutic platforms can assist delivery of therapeutic agents to the disease site through electrical stimulation. 7,8 Therefore, TENGs have great potential for application in cancer treatments through the self-powered manner and portable or wearable devices.…”

Section: Introductionmentioning

confidence: 99%

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Self-Driven Electrical Stimulation-Promoted Cancer Catalytic Therapy and Chemotherapy Based on an Implantable Nanofibrous Patch

Zheng

Yao

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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The efficacy of cancer catalytic therapy is still hindered by the inefficient generation of reactive oxygen species (ROS). Herein, we report a self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy by integrating a human-driven triboelectric nanogenerator (TENG) with an implantable and biodegradable nanofibrous patch. The gelatin/polycaprolactone nanofibrous patch incorporates doxorubicin (DOX) and graphitic carbon nitride (g-C3N4), in which the peroxidase (POD)-like activity of g-C3N4 to produce hydroxyl radical (•OH) can be distinctly enhanced by the self-driven electrical stimulation for 4.12-fold, and simultaneously DOX can be released to synergize the therapy, especially under a weakly acidic tumor microenvironment (TME) condition. The in vitro and in vivo experimental results on a mouse breast cancer model demonstrate superior tumor suppression outcome. The self-powered electrical stimulation-enhanced catalytic therapy and chemotherapy via multifunctional nanofibrous patches proposes a new complementary strategy for the catalytic therapy of solid tumors.

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Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy

Zhong

Xiong

Zhao

et al. 2023

Adv Funct Materials

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Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble the metal active centers of their natural counterparts. However, a significant challenge still exists for improving their catalytic activities, retarding their practical applications. Herein, this article presents that through the application of a human self‐driven triboelectric device to impose electrical stimulus, the multiple enzyme‐like activities of a single‐atom copper nanozyme (Cu‐NC) are remarkably improved, thereby boosting cancer cell oxidative damage and death for realizing improved therapy. Under an electrical stimulus with 20 V voltage, the peroxidase, catalase, oxidase, and glutathione oxidase like activities of Cu‐NC are all improved to boost the catalytic generation of free radicals. Through calculation, this work analyzes how the electrical stimulus modulates the catalytic activity via decreasing adsorption energy of H2O2 on Cu active sites, increasing Cu dxy orbital near the Fermi level, and shifting the d‐band center of Cu, facilitating the catalytic reactions. This work opens new perspectives on improving single‐atom nanoenzymes for cancer therapy.

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Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages

Cited by 38 publications

References 37 publications

Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

Self-Driven Electrical Stimulation-Promoted Cancer Catalytic Therapy and Chemotherapy Based on an Implantable Nanofibrous Patch

Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy

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