Self-assembly triggered by self-assembly: Optically active, paramagnetic micelles encapsulated in protein cage nanoparticles

Millán, Jealemy Galindo; Brasch, Melanie; Anaya‐Plaza, Eduardo; Escosura, Andrés de la; Velders, Aldrik H.; Reinhoudt, David N.; Torres, Tomás; Koay, M.S.T.; Cornelissen, Jeroen J. L. M.

doi:10.1016/j.jinorgbio.2014.01.004

Cited by 38 publications

(22 citation statements)

References 54 publications

(75 reference statements)

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“…Phthalocyanine dyes are one such class of photosensitizers, and self-assembly of CCMV with phthalocyanine encapsulated has been explored recently. 125, 287 CCMV coencapsulated with Gd(DOTA) micelles and phthalocyanine dyes resulted in better capsid stability and further imparts the possibility to perform combination therapy and MR imaging, 287 and thus it only remains to investigate their potential value in PDT.…”

Section: Applications Of Virus-based Particlesmentioning

confidence: 99%

Design of virus-based nanomaterials for medicine, biotechnology, and energy

2016

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Virus-based nanomaterials are versatile materials that naturally self-assemble and have relevance for a broad range of applications including medicine, biotechnology, and energy. This review provides an overview of recent developments in “chemical virology.” Viruses, as materials, provide unique nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas of applications. Some fundamental advantages of viruses, compared to synthetically programmed materials, include the highly precise spatial arrangement of their subunits into a diverse array of shapes and sizes and many available avenues for easy and reproducible modification. Here, we will first survey the broad distribution of viruses and various methods for producing virus-based nanoparticles, as well as engineering principles used to impart new functionalities. We will then examine the broad range of applications and implications of virus-based materials, focusing on the medical, biotechnology, and energy sectors. We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials.

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Section: Applications Of Virus-based Particlesmentioning

confidence: 99%

Design of virus-based nanomaterials for medicine, biotechnology, and energy

2016

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“…The sophisticated performance of viruses has been a source of inspiration in the field of self‐assembly, and there has been quite a number of reports on self‐assembled particles based on wrapping a macromolecular coat around a macromolecular template . However, binding on a polymeric template is apparently not the entire story . Lateral interaction within the coat also deserves attention; in our recent study it was shown that virus assembly can be successfully emulated by an artificial system consisting of DNA as the template, and a properly designed triblock polypeptide .…”

Section: Methodsmentioning

confidence: 99%

“…[3] However,b inding on ap olymeric template is apparently not the entire story. [4] Lateral interaction within the coat also deserves attention;i no ur recent study it was shown that virus assembly can be successfully emulated by an artificial system consisting of DNA as the template, and ap roperly designed triblock polypeptide. [5] The key of this polypeptide designs eems to be the combinationo ft hree blocks:a nN -terminal "protective" hydrophilic randomc oil block, as ilk-like midblockt hat provides strongl aterala ttraction between the polypeptides, and as hort cationic C-terminal block that interacts with the anionic template.T his system not only produced virus-like particles with the same rod-like shape and the same kinetics of assembly as the tobaccom osaicv irus (TMV), but it also obeyed the allosteric-assembly model quite well.Since the protein-protein interactions are so important, one may wonder whether the macromolecular template mattersa t all.…”

mentioning

confidence: 99%

Supramolecular Virus‐Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers

Hernández-García

Velders

Stuart

et al. 2016

Chemistry A European J

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We investigate a new case of a self-assembly-stimulated self-assembly in which a triblock polypeptide is combined with a anionic coordination polymer of a dipicolinic acid bis-ligand, and d- or f- block metal ions like Zn or Eu . The polypeptide not only has a silk-like domain that can fold and stack, but also a C-terminal cationic sequence by which it can interact with the supramolecular (coordination) polyanion. In the presence of all three ingredients (polypeptide, bis-ligand, and metal ions), we observe the initiation and slow growth of well-defined metal-containing nanorods of up to 150 nm in length, proving that self-assembly of the polypeptide is triggered by the self-assembly of the coordination polyelectrolyte and vice versa. The particles, which have a striking resemblance to rod-like viruses, are stable up to 1.2 m NaCl, and can be made fluorescent when lanthanides like Eu are used, showing the potential to exploit functional properties and applications of virus-like supramolecular structures.

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“…For example, a VLP based on bacteriophage Qβ was loaded with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand targeting cells bearing the CD22 receptor (65). Furthermore, a multifunctional MRI contrast and photodynamic therapy agent (chelated Gd 3+ and Zn 2+ phthalocyanine) was successfully encapsulated in CCMV as a first demonstration of theranostic VNPs (66). Hybrid VNP-based materials carrying metal nanoparticles for photothermal therapy have also been investigated (67).…”

Section: Drug Delivery With Virus-based Nanoparticlesmentioning

confidence: 99%

“…Less toxic Mn 3+ chelators have also been attached successfully to bacteriophage P22 (144). As stated earlier, a multifunctional MRI contrast and photodynamic therapy agent was created by the coencapsulation of chelated Gd 3+ and Zn 2+ phthalocyanine in a VNP based on CCMV particles (66). The amphipathic nature of Zn 2+ phthalocyanine allowed the chelated Gd 3+ to be loaded at a higher density, thus achieving a greater overall contrast (66).…”

Section: Virus-based Materials As Imaging Probesmentioning

confidence: 99%

Virus-Based Nanoparticles as Versatile Nanomachines

et al. 2015

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Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases. Viruses have played a special role in these developments because they can function as prefabricated nanoscaffolds that have unique properties and are easily modified. The interiors of virus particles can encapsulate and protect sensitive compounds, while the exteriors can be altered to display large and small molecules in precisely defined arrays. These properties of viruses, along with their innate biocompatibility, have led to their development as actively targeted drug delivery systems that expand on and improve current pharmaceutical options. Viruses are naturally immunogenic, and antigens displayed on their surface have been used to create vaccines against pathogens and to break self-tolerance to initiate an immune response to dysfunctional proteins. Densely and specifically aligned imaging agents on viruses have allowed for high-resolution and noninvasive visualization tools to detect and treat diseases earlier than previously possible. These and future applications of viruses have created an exciting new field within the disciplines of both nanotechnology and medicine.

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Self-assembly triggered by self-assembly: Optically active, paramagnetic micelles encapsulated in protein cage nanoparticles

Cited by 38 publications

References 54 publications

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Supramolecular Virus‐Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers

Virus-Based Nanoparticles as Versatile Nanomachines

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