Self-assembly of sodium glycyrrhetinate into a hydrogel: characterisation and properties

Wu, Jindan; Lu, Jinrong; Hu, Jun; Gao, Yuxia; Ma, Qiang; Ju, Yi‐Hsu

doi:10.1039/c3ra43306d

Cited by 31 publications

(31 citation statements)

References 55 publications

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“… 54 , 349 , 350 Lu et al recently reported that sodium glycyrrhetinate ( 84 ) is able to form a hydrogel with a CGC of 5.6 wt %, and the authors suggested the dipole–dipole interaction of sodium carboxylates as the main driving force for the hydrogelation of 84 . 351 Another related interesting work is the hydrolysis of succinated triamcinolone acetonide which forms triamcinolone acetonide and results in hydrogelation. 352 …”

Section: Molecular Designmentioning

confidence: 99%

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping address fundamental questions about the mechanisms or the consequences of the self-assembly of molecules, including low molecular weight ones. Finally, we provide a perspective on supramolecular hydrogelators. We hope that this review will serve as an updated introduction and reference for researchers who are interested in exploring supramolecular hydrogelators as molecular biomaterials for addressing the societal needs at various frontiers.

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Section: Molecular Designmentioning

confidence: 99%

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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“…Among these materials mentioned above, polymeric hydrogel is one of the most promising adsorbents due to their facile preparation, low-cost, and high-specic loading capacity. 12,13 Recently, various synthetic polymer based hydrogels have been fabricated, 14,15 such as poly(acrylic acid) (PAA) and polyacrylamide hydrogels, these obtained hydrogels demonstrated certain adsorption capability as effective adsorbent for various contaminants. However, the usage of these synthetic polymer engineered hydrogels also face several inherent shortages, e.g.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide interpenetrated polymeric composite hydrogels as highly effective adsorbents for water treatment

Cheng

Liu

et al. 2014

RSC Adv.

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Recent studies showed that polymeric hydrogels presented promising applications in adsorption to various water contaminants. However, the usages of these synthetic hydrogels are hindered by several inherent shortages, e.g. limited inner porosity, low adsorption capacity and long equilibrium time. In this study, synthetic GO interpenetrated poly(acrylic acid) (PAA) hydrogels as 3D highly-efficient adsorbents were prepared and systematically studied for the first time. The mediating ability of GO on the inner structure and adsorption capacities is examined using two types of PAA hydrogels (PAA1 and PAA2 with different inner structures, prepared by in situ cross-linked polymerization of monomer AA). The results indicated that the prepared PAA2/GO hydrogels exhibited a well-defined and interconnected 3D porous network, which allowed the adsorbate molecules to diffuse easily into the absorbent. The adsorption experiments indicated that the obtained interconnected polymeric composite hydrogels could efficiently remove cationic dyes and heavy metal ions from wastewater; the highest adsorption capacity of the prepared PAA2/GO composite hydrogels could reach as high as 1600 mg g À1 , which is highly promising in the treatment of environmental toxins. Moreover, the initial concentration, pH value, desorption ratio, dynamic kinetics and isotherms of the methylene blue (MB) adsorption processes of the prepared PAA2/ GO composite hydrogels were also studied in detail. The experimental data of MB adsorption fitted the pseudo-second-order kinetic model and the Langmuir isotherm very well, and the adsorption process was controlled by the intraparticle diffusion. Moreover, due to its facile preparation and low-cost, the GO interpenetrated PAA composite hydrogels may function as promising adsorbents for wastewater treatment, and this method might also be extended to improve the adsorption capacity of other polymeric hydrogels.

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“…However, the formation of the above-mentioned glycyrrhetinic-acid-based supramolecular gel requires the use of organic solvents, which greatly limits the application of glycyrrhetinic acid in the biomedical field. To solve this problem, the Ju group reported the first glycyrrhetinic-acid-based supramolecular hydrogel in 2013 [74]. The authors found that an opaque and thermally reversible hydrogel could be formed by slightly heating and dissolving a certain amount of sodium glycyrhizinate in an alkaline aqueous solution with pH > 9 and then cooling.…”

Section: Glycyrrhetinic Acid Based Low-molecular-weight Supramolecular Gelsmentioning

confidence: 99%

Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels

Luo

Jian

et al. 2021

Gels

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Natural small molecular drugs with excellent biocompatibility, diverse pharmacological activities, and wide sources play an increasingly important role in the development of new drug and disease treatment. In recent years, the utilization of paclitaxel, camptothecin, rhein, curcumin, and other natural small molecular drugs with unique rigid backbone structures and modifiable multiple sites as building blocks to form gels by self-assembly has attracted widespread attention. The obtained low-molecular-weight supramolecular gel not only retains the general characteristics of the gel but also overcomes the shortcomings of natural drugs, such as poor water solubility and low bioavailability. It has the advantages of high drug loading, low toxicity, and outstanding stimulus responsiveness, which is widely used in biomedical fields. Here, we provided a comprehensive review of natural-drugs-based low-molecular-weight supramolecular gels reported in recent years and summarized their assembly mechanism, gel structure, gel properties, and potential applications. It is expected to provide a reference for further research of natural-drugs-based supramolecular gels.

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Self-assembly of sodium glycyrrhetinate into a hydrogel: characterisation and properties

Cited by 31 publications

References 55 publications

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

Graphene oxide interpenetrated polymeric composite hydrogels as highly effective adsorbents for water treatment

Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels

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