Self‐Assembly of Polyoxometalate–Peptide Hybrids in Solution: Elucidating the Contributions of Multiple Possible Driving Forces

Abstract

Abstract:Incorporating the building blocks of nature (e.g., peptides and DNA) into inorganic polyoxometalate (POM) clusters is a promising approach to improve the compatibilities of POMs in biological fields. To extend their biological applications, it is necessary to understand the importance of different non-covalent interactions during self-organization. A series of Anderson POM-peptide hybrids have been used as a simple model to demonstrate the role of different interactions in POM-peptide (biomolecules) systems. Regardless of peptide chain length, these hybrids follow similar solution behaviors,

Beyond Charge Balance: Counter‐Cations in Polyoxometalate Chemistry

“…Since their initial discovery, Blackberry formation is now accepted as a common phenomenon for inorganic POMs [89,90] and for amphiphilic POMs that are functionalized by hydrophobic organic "tails". [91][92][93][94][95] Also noteworthy, the uranyl peroxide polyoxometalates of several distinct geometries and compositions, [52,[96][97][98] as well as the noble metal POMs, [99,100] also assemble into blackberry structures, indicating the universality of the underlying structure formation processes. Beyond the scope of this Review, blackberry structures have also assembled from cationic coordination compound nanocages.…”

“…Blackberry structures, now well‐known amongst the metal–oxo cluster community, are solution‐phase hollow capsules containing hundreds to thousands of POMs that are associated by counter‐cations in a single curved layer, comprising the blackberry surface (Figure ). Since their initial discovery, Blackberry formation is now accepted as a common phenomenon for inorganic POMs and for amphiphilic POMs that are functionalized by hydrophobic organic “tails” . Also noteworthy, the uranyl peroxide polyoxometalates of several distinct geometries and compositions, as well as the noble metal POMs, also assemble into blackberry structures, indicating the universality of the underlying structure formation processes.…”

Polyoxometalates as components of supramolecular assemblies

“…7b). The aggregation of the biomoiety-decorated POMs can be viewed as a model system for the investigation of various biomolecular interactions that may take place during biological processes 53. The diversity of the nanostructures self-assembled by POM-based supramolecular aggregates in various solvents was also demonstrated for the {[P 2 W 17 O 61 (O(Si–C 29 H 18 N 3 ) 2 )] 3 ·Fe 3 } compound which exhibits discrete triangular units in DMSO, while in acetonitrile the {[P 2 W 17 O 61 (O(Si–C 29 H 18 N 3 ) 2 )] 3 ·Fe 3 } moieties form monodisperse nanoparticles (Fig.…”

Jenseits von Ladungsausgleich: Gegenkationen in der Polyoxometallat‐Chemie

“…[80,81] [89,90] und auch für amphiphilie POMs, die durch einen hydrophoben "Schwanz" funktionalisiert sind, akzeptiert. [91][92][93][94][95] Weiterhin beachtenswert ist die Bildung von Blackberrys durch Uranylperoxid-POMs mit unterschiedlichen Geometrien und Zusammensetzun-…”

“…Sie sind hohle Kapseln, die aus Hunderten bis Tausenden von POMs bestehen, die kationenvermittelt zu einer gekrümmten Oberfläche verbunden werden (Abbildung ). Seit ihrer Entdeckung wurde die Blackberry‐Bildung mittlerweile als allgemeines Phänomen für anorganische POMs und auch für amphiphilie POMs, die durch einen hydrophoben “Schwanz” funktionalisiert sind, akzeptiert . Weiterhin beachtenswert ist die Bildung von Blackberrys durch Uranylperoxid‐POMs mit unterschiedlichen Geometrien und Zusammensetzungen sowie durch Edelmetall‐POMs .…”