Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure

Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Albanese, Antonella; Calascibetta, Filippo; Giammona, Gaetano

doi:10.1016/j.actbio.2009.06.014

Cited by 39 publications

(26 citation statements)

References 31 publications

(41 reference statements)

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“…A reasonable explanation for these data involves consideration of stacking geometry dictated by electrostatic complementarity in the context of a desolvation driving force. “The observed increasing association constants with increasing solvent polarity provide compelling evidence that the hydrophobic effect, that is, desolvation of the aromatic faces, provides the dominant driving force for association” …”

Section: Resultsmentioning

confidence: 95%

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Catenacci

Mandracchia

Sorrenti

et al. 2014

Macro Chemistry & Physics

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H NMR is a suitable method to clarify the kind of interactions leading to the self-assembly of amphiphilic polymers. This work shows, from 1 H NMR studies performed in solution, that the self-assembly ability of the synthesized Inulin-D -α-tocopherol succinate (INVITE) amphiphilic polymers, can be addressed to specifi c π-π interactions between the aromatic regions of D -α-tocopherol. This result suggests the use of INVITE systems for the preferential loading of aromatic group bearing drugs such as curcumin. The preparation conditions, effect of drug loading, and lyophilization on the INVITE systems are evaluated by DSC and thermogravimetric analysis (TGA) analysis to assess whether common pharmaceutical processes could infl uence the physical properties of the amphiphilic polymers, such as crystallinity, glass-transition temperature or thermal degradation, to predict the physical stability of the systems upon administration. Furthermore, the size stability of the micelle systems up to 60 days is monitored to assess the feasibility of the INVITE micelles' long-term storage upon reconstitution with water.

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Section: Resultsmentioning

confidence: 95%

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Catenacci

Mandracchia

Sorrenti

et al. 2014

Macro Chemistry & Physics

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“…HA ( M w , 280 kDa, polydispersity index, PDI, 1.9), its tetrabutylammonium salt, and the tetrabutylammonium salt of HA XS were produced as reported in refs. . Octadecylamine (C 18 ‐NH 2 ), tetrabutylammonium hydroxide, bis(4‐nitrophenyl) carbonate, picrylsulfonic acid solution (2,4,6‐trinitrobenzenesulfonic acid, TNBS), methoxypolyethylene glycol amine, N ‐hydroxysuccinimide (NHS), (2‐hydroxypropyl)‐β‐cyclodextrin (HPCD), Dulbecco's phosphate buffered saline (DPBS), diethyl ether, chloroform, ethanol (EtOH), anhydrous dimethylsulfoxide (DMSO), tetramethylammonium chloride (TMACl), N ‐(3‐dimethylaminopropyl)‐ N ′‐ethylcarbodiimide hydrochloride (EDC), fibronectin from bovine plasma, bicinchoninic acid (BCA) solution, and copper(II) sulfate solution (4%, w/v) were purchased from Sigma‐Aldrich (Italy).…”

Section: Methodsmentioning

confidence: 99%

Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative

Agnello

Bongiovì

Fiorica

et al. 2017

Macro Materials & Eng

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The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA‐EDA‐C18 derivatives (125 and 320 kDa) having ionic strength sensitive properties are synthesized and characterized. The control of the rheological properties of HA‐EDA‐C18 aqueous dispersions by formation of inclusion complexes with hydroxypropyl‐β‐cyclodextrins (HPCD) is described. Reversibility of C18/HPCD complexation and physical crosslinking is detected in media with different ionic strength through oscillation frequency tests. HA‐EDA‐C18 125 kDa is employed for nanogel fabrication. Control over nanogel dimension by flow ratio regulation is demonstrated. HA‐EDA‐C18 320 kDa with HPCD is employed for fabrication of both microfibers and microchannels. Dimension of fibers is controlled by modulating flow ratios. Suitability for biological functionalization is assayed introducing cell adhesive peptides. Adhesion and encapsulation of human umbilical vein endothelial cells is evaluated.

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“…These interactions are indeed weak and may be influenced by external conditions such as temperature. 31 Other cross-linking techniques include cross-linking with polyfunctional epoxides or with glutaraldehyde and with carbodiimides. [32][33][34][35] Jeon et al described how the mechanical properties and degradation behaviors of the cross-linked HA hydrogels may be influenced by the density and molecular weight of the cross-linker.…”

Section: Ha Productionmentioning

confidence: 99%

Cross-Linked Hyaluronic Acid as Tear Film Substitute

Posarelli

Passani

et al. 2019

Journal of Ocular Pharmacology and Therapeutics

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The aim of this review is to clarify the role of cross-linked Hyaluronic acid (HA) molecule as a tear supplement and to define its possible applications in dry eye disease. Methods: Current Literature about HA and its cross-linked derivatives has been examined. Results: HA is superior in increasing the viscosity and stability of the tear film compared with other tear supplements such as polyvinyl alcohol, hydroxypropyl methylcellulose, carboximethyl cellulose and polyethylene glycol. Moreover, HA can be modified in different ways to improve its properties such as molecular weight, viscosity, and hydrophobicity to adapt the new artificial molecule to different aims. Conclusions: The current pharmacological trend is to improve the properties of HA by cross-linking parts of the molecule to achieve better bioavailability and resistence to degradation. In dry eye disease, cross-linked HA as tear supplement seems to provide better ocular comfort than linear HA and is therefore subjected to growing interest and diffusion.

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Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure

Cited by 39 publications

References 31 publications

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative

Cross-Linked Hyaluronic Acid as Tear Film Substitute

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Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure

Cited by 39 publications

References 31 publications

In‐Solution Structural Considerations by 1H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by 1H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative

Cross-Linked Hyaluronic Acid as Tear Film Substitute

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Product

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In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs