Self-assembled PEG–carboxymethylcellulose nanoparticles/α-cyclodextrin hydrogels for injectable and thermosensitive drug delivery

Dai, Lin; Li, Rui; Hu, Liqiu; Wang, Junhui; Si, Chuanling

doi:10.1039/c6ra25793c

Cited by 33 publications

(14 citation statements)

References 43 publications

(20 reference statements)

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“…The most commonly used thermoresponsive hydrogels are prepared from natural polymers, [141,142] proteins or polypetides, [80,143,144] pluronics, [145,146] and copolymers based on PCL, [147][148][149][150] PNIPAAM, [151][152][153][154][155][156][157] poly(d,l-lactide) (PLA), [158][159][160][161] PEG, [144,150,162] poly(amino ester urethane) (PAEU). [163,164] PNIPAAM is a widely used temperature-responsive polymer for the preparation of temperature-responsive hydrogels for controlled drug delivery applications.…”

Section: Temperature-responsive Injectable Hydrogels For Controlled Amentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

199

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Section: Temperature-responsive Injectable Hydrogels For Controlled Amentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

199

152

View full text Add to dashboard Cite

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“…In vivo studies showed that this hydrogel was more effective than free drugs and drug-loaded micelles. This same concept was extended while using micelles that were prepared from carboxymethylcellulose for betulinic acid/hydroxycamptothecine system delivery [184]. Similarly, Shi et al [185] prepared a tunable temperature-responsive polypseudorotaxane hydrogel based on pegylated camptothecin, an amphiphilic anticancer prodrug.…”

Section: α-Cyclodextrin/nanovehicle-based Polypseudorotaxane Hydrogelsmentioning

confidence: 99%

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

2019

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Supramolecular hydrogels that are based on inclusion complexes between α-cyclodextrin and (co)polymers have gained significant attention over the last decade. They are formed via dynamic noncovalent bonds, such as host-guest interactions and hydrogen bonds, between various building blocks. In contrast to typical chemical crosslinking (covalent linkages), supramolecular crosslinking is a type of physical interaction that is characterized by great flexibility and it can be used with ease to create a variety of "smart" hydrogels. Supramolecular hydrogels based on the self-assembly of polypseudorotaxanes formed by a polymer chain "guest" and α-cyclodextrin "host" are promising materials for a wide range of applications. α-cyclodextrin-based polypseudorotaxane hydrogels are an attractive platform for engineering novel functional materials due to their excellent biocompatibility, thixotropic nature, and reversible and stimuli-responsiveness properties. The aim of this review is to provide an overview of the current progress in the chemistry and methods of designing and creating α-cyclodextrin-based supramolecular polypseudorotaxane hydrogels. In the described systems, the guests are (co)polymer chains with various architectures or polymeric nanoparticles. The potential applications of such supramolecular hydrogels are also described.

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“…Temperature was slowly increased and sol-to-gel temperature of the nanoformulations measured upon inversion of the vials. 18 The gelling temperature range suitable for the intranasal gels is 30-34°C.…”

Section: Sol-to-gel Transition Temperaturementioning

confidence: 99%

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

et al. 2019

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Purpose: Rivastigmine hydrogen tartrate (RHT) is commonly used for the treatment of mild to moderate Alzheimer’s disease (AD). The aim of this work was to formulate in-situ pluronic F-127 (PF-127) hydrogels containing Eudragit RL-100 (EU-RL) nanoparticles (NPs) in order to improve the therapeutic efficacy of RHT through the nasal route. Methods: The NPs were prepared using different polymer to drug ratios and evaluated for their physicochemical characteristics, cellular uptake and in vitro cytotoxicity against lung adenocarcinoma cells (A459). PF-127 nanoformulations were prepared via cold method and analyzed in terms of physicochemical properties and drug release profiles. The nanoformulations and plain drug gel were then assessed by ex vivo permeation studies across the sheep nasal mucosa. Results: The EU-RL NPs exhibited a particle size within the range of 118 to 154 nm and positive zeta potential values of 22.5 to 30 mV with an approximately spherical shape. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD) suggested no drug to polymer interaction through the preparation of nanoformulations. The RHT-loaded NPs exhibited an acceptable cytocompatibility with a time- and dose-dependent cellular internalization. Conclusion: Our results clearly indicated the potential of nanoformulations as controlled release systems to improve the therapeutic efficacy of RHT through the intranasal administration

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Self-assembled PEG–carboxymethylcellulose nanoparticles/α-cyclodextrin hydrogels for injectable and thermosensitive drug delivery

Cited by 33 publications

References 43 publications

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

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